Production of biliverdin by biotransformation of exogenous heme using recombinant Pichia pastoris cells
Jianfeng Mei,
Yanchao Han,
Shihang Zhuang
et al.
Abstract:Biliverdin, a bile pigment hydrolyzed from heme by heme oxygenase (HO), serves multiple functions in the human body, including antioxidant, anti-inflammatory, and immune response inhibitory activities. Biliverdin has great potential as a clinical drug; however, no economic and efficient production method is available currently. Therefore, the production of biliverdin by the biotransformation of exogenous heme using recombinant HO-expressing yeast cells was studied in this research. First, the heme oxygenase-1 … Show more
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