Production and efficacy of an Aeromonas hydrophila recombinant S-layer protein vaccine for fish

Post-challenge immune gene expression profiling in rohu, Labeo rohita vaccinated with modified adjuvant-basedohu, Aeromonas hydrophila outer membrane protein R formulationˆ:l3

“…The rOmpR component of A. hydrophila might be able to mimic the pathogen itself, thus resulting in higher levels of protective antibody, as reflected in the postchallenge survival rate of rOmpR vaccinated groups (DASH et al, 2014). An elevated IgM titer was marked in A. hydrophila resistant common carp families, when challenged with the specific pathogen (ARDO et al, 2010). C3 is considered to be an important antimicrobial weapon of teleosts, which initiates complement mediated opsonization during infection (DAS et al, 2011).…”

“…On the other hand, no correlation was found with an increase in the expression of genes involved in specific immunity in response to viral haemorrhagic septicaemia virus in DNA-vaccinated rainbow trout, and involvement of memory cells was thought to play a role in stimulating host immunity (CUESTA and TAFALLA, 2009). As far as the quantity and cost effectivity of vaccines are concerned, recombinant vaccines have been proved to be one of the best alternatives (POOBALANE et al, 2010). In addition to vaccines, adjuvants play an important role in induction of stronger immune response.…”

Essential Roles of TIM-1 and TIM-4 Homologs in Adaptive Humoral Immunity in a Zebrafish Model

“…One group was i.p. immunized with a bacterial vaccine (1 3 10 6 CFU) derived from 0.5% formaldehydeinactivated Aeromonas hydrophila, a pathogen of infectious sepsis in fish (52). The other group was also immunized with the same bacterial vaccine at the same dosage, with the exception of the administration of antiDrTIM-1 and anti-DrTIM-4 (10 mg/fish) as described above.…”

Transcriptional profiles of multiple genes in the anterior kidney of channel catfish vaccinated with an attenuated Aeromonas hydrophila

“…Furthermore, live attenuated vaccines such as aroA mutant and transposon Tn916-generated mutant have been reported to confer significant protection against homologous A. hydrophila challenge [25,26]. However, it is well known that A. hydrophila is very heterogeneous biochemically and serologically, which is the biggest obstacle in developing effective commercial vaccine against A. hydrophila [23,27]. To prevent future disease outbreaks caused by the highly virulent West Alabama 2009 isolates of A. hydrophila, an attenuated vaccine AL09-71 NþR specifically targeting A. hydrophila AL09-71 was developed [28].…”