Prodromal Dementia With Lewy Bodies: Clinical Characterization and Predictors of Progression

Beek, Marleen van de; Steenoven, Inger van; Zande, Jessica J. van der; Barkhof, Frederik; Teunissen, Charlotte E.; Flier, Wiesje M. van der; Lemstra, Afina W.

doi:10.1002/mds.27997

Cited by 40 publications

(44 citation statements)

References 51 publications

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“…Since only one study met the full inclusion criteria (Massa et al, 2019 ), we post hoc chose to include studies that did not have HCs and had unclear diagnostic criteria. Doing this we ended up with a total of four articles for this review (Massa et al, 2019 ; Unger et al, 2019 ; van de Beek et al, 2020 ; Yoo et al, 2020 ). See Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The last three included studies did not, for various reasons, meet our full inclusion criteria. van de Beek et al ( 2020 ) did not include HCs, Unger et al ( 2019 ) lacked both HCs and had an unclear MCI definition, and lastly Yoo et al ( 2020 ) both had an unclear MCI definition and a combined PD/DLB-MCI group.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, a deterioration in attentional (Unger et al, 2019 ; van de Beek et al, 2020 ) and visuospatial/executive function (Unger et al, 2019 ) has been reported for DLB-MCI patients converting to dementia. Interestingly, van de Beek et al ( 2020 ) also found that a poorer attentional function at first visit was associated with faster progression to dementia. The authors then concluded that this probably is an effect of these patients being closer to dementia, as DLB is characterized with more prominent attentional dysfunction early on in the disease course.…”

Section: Resultsmentioning

confidence: 99%

“…Further, some used composite scores (van de Beek et al, 2020;Yoo et al, 2020), while other analyzed isolated test scores (Massa et al, 2019;Unger et al, 2019). Moreover, some of the studies used standardized scores in the analyses (van de Beek et al, 2020;Yoo et al, 2020), while others used raw scores (Massa et al, 2019;Unger et al, 2019). This is somewhat problematic, due to age, sex, and educational differences between the subjects, as well as substantial differences in the normative basis for the different tests.…”

Section: Discussionmentioning

confidence: 99%

“…van de Beek et al 2020 Despite this, summed findings do point to DLB-MCI patients having poorer executive and visuospatial function compared to AD-MCI patients (van de Beek et al, 2020) and poorer executive and attentional functioning compared to HCs (Yoo et al, 2020). Moreover, a deterioration in attentional (Unger et al, 2019;van de Beek et al, 2020) and visuospatial/executive function (Unger et al, 2019) has been reported for DLB-MCI patients converting to dementia. Interestingly, van de Beek et al (2020) also found that a poorer attentional function at first visit was associated with faster progression to dementia.…”

Section: Synthetisized Findingsmentioning

confidence: 98%

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The Cognitive Profile of Mild Cognitive Impairment Due to Dementia With Lewy Bodies—An Updated Review

Hemminghyth¹,

Chwiszczuk²,

Rongve³

et al. 2020

Front. Aging Neurosci.

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Objective: Dementia with Lewy Bodies (DLB) is the second most common type of neurodegenerative dementia. Yet, the domain-specific cognitive impairment of the mild cognitive impairment (MCI) phase of this disease (DLB-MCI) is still not been established. This article gives an updated review on the neuropsychological profile of DLB-MCI, building on the findings from a previous review.Methods: We performed systematic review and searched five different electronic databases (Scopus, Cochrane, EMBASE, MEDLINE, and PsycINFO) in May 2020 based on a PICO scheme. Our search was then restricted to articles published in 2019 and 2020. Ending up with a total of 90 articles to be reviewed by abstract and/or full text.Results: In total four papers were included, whereof only one met our full inclusion criteria. Despite a substantial heterogeneity, our findings indicate that DLB-MCI patients have a pattern of executive, visuospatial, and attentional deficits.Conclusion: The findings indicate that the neuropsychological profile of DLB-MCI is characterized by executive, visuospatial, and attentional deficits. Furthermore, the shortage of studies clearly underlines the paucity of published research into DLB-MCI and emphasizes the need for well-controlled studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Synthetisized Findingsmentioning

confidence: 98%

See 3 more Smart Citations

The Cognitive Profile of Mild Cognitive Impairment Due to Dementia With Lewy Bodies—An Updated Review

Hemminghyth¹,

Chwiszczuk²,

Rongve³

et al. 2020

Front. Aging Neurosci.

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Research diagnostic criteria for mild cognitive impairment with Lewy bodies: A systematic review and meta‐analysis

Donaghy

Carrarini

Ferreira

et al. 2023

Alzheimer's & Dementia

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Introduction Operationalized research criteria for mild cognitive impairment with Lewy bodies (MCI‐LB) were published in 2020. The aim of this systematic review and meta‐analysis was to review the evidence for the diagnostic clinical features and biomarkers in MCI‐LB set out in the criteria. Methods MEDLINE, PubMed, and Embase were searched on 9/28/22 for relevant articles. Articles were included if they presented original data reporting the rates of diagnostic features in MCI‐LB. Results Fifty‐seven articles were included. The meta‐analysis supported the inclusion of the current clinical features in the diagnostic criteria. Evidence for striatal dopaminergic imaging and meta‐iodobenzylguanidine cardiac scintigraphy, though limited, supports their inclusion. Quantitative electroencephalogram (EEG) and fluorodeoxyglucose positron emission tomography (PET) show promise as diagnostic biomarkers. Discussion The available evidence largely supports the current diagnostic criteria for MCI‐LB. Further evidence will help refine the diagnostic criteria and understand how best to apply them in clinical practice and research. Highlights A meta‐analysis of the diagnostic features of MCI‐LB was carried out. The four core clinical features were more common in MCI‐LB than MCI‐AD/stable MCI. Neuropsychiatric and autonomic features were also more common in MCI‐LB. More evidence is needed for the proposed biomarkers. FDG‐PET and quantitative EEG show promise as diagnostic biomarkers in MCI‐LB.

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Optimizing cCOG, a Web‐based tool, to detect dementia with Lewy Bodies

Gils

Beek

Unnik

et al. 2022

Alz & Dem Diag Ass & Dis Mo

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Introduction Distinguishing dementia with Lewy bodies (DLB) from Alzheimer's disease (AD) is challenging due to overlapping presentations. We adapted a Web‐based test tool, cCOG, by adding a visuospatial task and a brief clinical survey and assessed its ability to differentiate between DLB and AD. Methods We included 110 patients (n = 30 DLB, n = 32 AD dementia, and n = 48 controls with subjective cognitive decline (SCD)). Full cCOG comprises six cognitive subtasks and a survey addressing self‐reported DLB core and autonomic features. First, we compared cCOG cognitive tasks to traditional neuropsychological tasks for all diagnostic groups and clinical questions to validated assessments of clinical features in DLB only. Then, we studied the performance of cCOG cognitive tasks and clinical questions, separately and combined, in differentiating diagnostic groups. Results cCOG cognitive tasks and clinical survey had moderate to strong correlations to standard neuropsychological testing (.61≤ rs ≤ .77) and to validated assessments of clinical features (.41≤ rs ≤ .65), except for fluctuations and REM‐sleep behavior disorder (RBD) (rs = .32 and rs = .10). Full cCOG, including both cognitive tasks and brief survey had a diagnostic accuracy (acc) of 0.82 [95% CI 0.73–0.89], with good discrimination of DLB versus AD (acc 0.87 [0.76–0.95]) and DLB versus controls (acc 0.94 [0.86–0.98]). Conclusion We illustrated that cCOG aids in distinguishing DLB and AD patients by using remote assessment of cognition and clinical features. Our findings pave the way to a funneled, harmonized diagnostic process among memory clinics and, eventually, a more timely and accurate diagnosis of DLB and AD.

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Prodromal Dementia With Lewy Bodies: Clinical Characterization and Predictors of Progression

Cited by 40 publications

References 51 publications

The Cognitive Profile of Mild Cognitive Impairment Due to Dementia With Lewy Bodies—An Updated Review

The Cognitive Profile of Mild Cognitive Impairment Due to Dementia With Lewy Bodies—An Updated Review

Research diagnostic criteria for mild cognitive impairment with Lewy bodies: A systematic review and meta‐analysis

Optimizing cCOG, a Web‐based tool, to detect dementia with Lewy Bodies

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