Procollagen III N-Terminal Peptide Predicts Short-Term Prognosis and Cardiac Remodeling in Coronary Heart Disease Patients With Metabolic Syndrome

Deng, Wen-feng; Chen, Qingwei; Li, Guiqiong; Li, Xingsheng; Ke, Danxia; Mo, Xiangang; Wang, Li; Wang, Peng; Wu, Zhiqin

doi:10.1097/maj.0b013e3181f080d8

Cited by 3 publications

(4 citation statements)

References 25 publications

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“…Our results showed that PIIINP levels are elevated in PAH subjects compared to healthy controls; and these levels correlated with markers of disease severity such as worsening WHO FC, cardiac index and six-minute walk distance. It was interesting that, although PIIINP is shown to increase with age (22) elsewhere, PIIINP levels in our study were negatively correlated with age and duration of disease. We hypothesize that this is likely due to a role in increased collagen turnover due to more aggressive vascular remodeling in patients with more severe disease.…”

Section: Discussionmentioning

confidence: 47%

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Circulating Collagen Biomarkers as Indicators of Disease Severity in Pulmonary Arterial Hypertension

Safdar

Tamez

Chan

et al. 2014

JACC: Heart Failure

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Objective The goal of this study was to determine if biomarkers of collagen metabolism in pulmonary arterial hypertension (PAH) identify patients with worse disease and higher risk of death. Background The relationship between markers of collagen metabolism, degree of disease, and outcome in PAH is unknown. Methods Stable idiopathic, anorexigen-associated and hereditary PAH patients were prospectively enrolled. Collagen biomarkers levels were measured: N-terminal propeptide of type III procollagen (PIIINP), C-terminal telopeptide of collagen type I (CITP), matrix metalloproteinsase 9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1). Patients were divided into mild, moderate, and severe PAH groups. Data was compared between tertiles of each biomarker. Pearson correlation and Spearman rank coefficient analyses were performed. Data on time to death or transplantation was examined by Kaplan-Meier survival curves. Results Circulating levels of PIIINP, CITP, MMP9 and TIMP1 were higher in the PAH group (N=68) as compared to age- and gender-matched healthy controls (N=37) (p<0.001 for each). PIIINP levels increased with the severity of disease (p=0.004). PIIINP tertile data indicated that with increasing levels, six-minute walk distance (6MWD) and cardiac index (CI) decreased and WHO FC worsened, and resting heart rate increased. A significant correlation existed between PIIINP with worsening WHO FC (rs=0.319, p=0.008) and a negative correlation with CI and 6MWD (r=-0.304 and -0.361 respectively; p<0.05). PIIINP tertiles showed a trend towards worse outcome in patients with higher tertile (lung transplant or death) (p=0.07, log rank test). Conclusions Markers of collagen metabolism were associated with worse disease in PAH patients.

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Section: Discussionmentioning

confidence: 47%

“…Published data suggest that PIIINP increases with age (22). Interestingly, we found that our study patients who had higher PIIINP levels were significantly younger.…”

Section: Discussionmentioning

confidence: 99%

Circulating Collagen Biomarkers as Indicators of Disease Severity in Pulmonary Arterial Hypertension

Safdar

Tamez

Chan

et al. 2014

JACC: Heart Failure

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“…Such results are consistent with those from an investigation of foundational patients with hypertension with left ventricular hypertrophy indicating raised PIIINP and TIMP1 rates announced by Agrinier et al in 2013. The (Deng et al,2011) studies were in agreement with the results research indicate increased age in PIIINP.…”

Section: Comparison Of Piiinp In Hypertension Patients Among Different Age Groupssupporting

confidence: 92%

“…PIIINP levels are raised In patients with PAH, PIIINP rates are higher relative to safe samples, associated with illness seriousness measures for example deteriorating WHO FC, cardiovascular record and 6MWD. Interestingly, although rates of PIIINP have been shown to increase with age elsewhere (Deng et al . ,2011).…”

Section: Comparison Of Piiinp In Hypertension Patients Among Different Age Groupsmentioning

confidence: 99%

Precollagen Type III N-terminal Propeptide (PIIINP) a Biomarker Onset in Hypertensive Patients

Mohammed

Jaber

al-Zubaidi

2020

Med.Sci.Jour.Adv.Res

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The aim of this study is to asses PIIINP, lipid profile and BMI serum levels in patients with hypertension. The current research The results were Get it from the Draw Blood unity in Al-Sadder infirmary Teaching , Al-Najaf, Iraq, And AL HAKEEM General infirmary in AL-Najaf, Iraq, in 10 Dec 2018 – 19 Jan 2019. Age of hypertensive patients from 40 to Age 70 Normal blood pressure 40 to 70 years. The score show, serious increase (p<0.05) in PIIINP compared with control groups in patients with hypertension. For female patients, the findings of the reported substantially increased (p<0.05) for PIIINP relative to male patient groups. The findings showed a substantial increase (p<0.05) in PIIINP in age (60-70) relative to age (50-59) and (40-49) and increased substantially (p<0.05) in PIIINP in age (50-59) relative to age (40-49); The results showed significant differences in BMI between the hypertensive and the normotensive

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The complementary role of high sensitivity C-reactive protein in the diagnosis and severity assessment of autism

Khakzad¹,

Javanbakht²,

Shayegan³

et al. 2012

Research in Autism Spectrum Disorders

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Procollagen III N-Terminal Peptide Predicts Short-Term Prognosis and Cardiac Remodeling in Coronary Heart Disease Patients With Metabolic Syndrome

Cited by 3 publications

References 25 publications

Circulating Collagen Biomarkers as Indicators of Disease Severity in Pulmonary Arterial Hypertension

Circulating Collagen Biomarkers as Indicators of Disease Severity in Pulmonary Arterial Hypertension

Precollagen Type III N-terminal Propeptide (PIIINP) a Biomarker Onset in Hypertensive Patients

The complementary role of high sensitivity C-reactive protein in the diagnosis and severity assessment of autism

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