volume 26, issue 5, P596-629 2012
DOI: 10.3109/02688697.2012.723170
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Abstract: Objectives. Prognosis for glioblastoma multiforme (GBM) has remained poor. Th ere is almost always recurrence postresection and adjuvant treatment, the majority of which is local. Several preclinical models exist that recapitulate the essential features of GBM. Th e majority of these models treat GBM in the neoadjuvant setting. Here, we describe an imageable intracranial surgical resection model of GBM in the rodent. Methods . We implanted 106 U87 luciferase-expressing GBM cells into the right hemisphere of 6…

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