Procalcitonin (PCT) in cardiac surgery: diagnostic value in systemic inflammatory response syndrome (SIRS), sepsis and after heart transplantation (HTX)

Boeken, Udo

doi:10.1016/s0967-2109(00)00070-3

Cited by 47 publications

(30 citation statements)

References 8 publications

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“…In addition, the fact that the CPB CAB group showed higher post-operative levels than the OP CAB group suggests a selective increase of PCT by ECC. This hypothesis is corroborated by other studies [6,7,20,21] showing comparable results.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Pro-inflammatory cytokines after different kinds of cardio-thoracic surgical procedures: is what we see what we know?

Franke¹,

Lante²,

Fackeldey³

et al. 2005

European Journal of Cardio-Thoracic Surgery

147

115

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Surgical trauma and reperfusion injury appear to represent the predominant factors resulting in immunologic changes after cardiac surgery. Cardiopulmonary bypass (CPB) may be less important for immune response and acute-phase reactions than previously suspected. In addition, our data indicate a relationship between IL-6 synthesis and the degree of surgical trauma. IL-8 appears to be elevated only after cardiac surgery whereas PCT liberation depended on the use of ECC.

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Section: Discussionsupporting

confidence: 91%

“…PCT is becoming more and more clinically relevant because it is known to be markedly elevated in the serum of patients under stressful conditions (infection, sepsis, burns, etc.) [6,7,20,21]. Its cellular origin or possible PCT-inducing stimulatory factors have not yet been completely clarified [22].…”

Section: Discussionmentioning

confidence: 99%

Pro-inflammatory cytokines after different kinds of cardio-thoracic surgical procedures: is what we see what we know?

Franke¹,

Lante²,

Fackeldey³

et al. 2005

European Journal of Cardio-Thoracic Surgery

147

115

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“…In these patients with high levels of over 10 ng/ml the decrease of PCT was slower than in the group of patients with values between 2 ng/ml and 10 ng/ml. Several studies have suggested the correlation between PCT levels and the severity of infection [16][17][18][19][20]. In the presented trial PCTalso had a good correlation with the postoperative course in case of SIRS or sepsis: Patients with very high PCT values showed clinical signs of a SIRS or sepsis which may be due to transient or persistent bacteraemia after decortication.…”

Section: Discussionmentioning

confidence: 82%

Comparison of procalcitonin and CrP in the postoperative course after lung decortication

Carboni

Fahrner

Gazdhar

et al. 2008

European Journal of Cardio-Thoracic Surgery

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Objective: The objective of this prospective study was to compare the clinical value of procalcitonin (PCT) and C-reactive protein (CrP) plasma concentrations in their postoperative course after decortication. Methods: Twenty-two patients requiring surgery for pleural empyema were chosen for this prospective study. Routine blood samples including CrP and PCT plasma concentrations were taken before the operation and on the 1st, 2nd, 3rd, and 7th postoperative day. Results: Due to infection PCT and CrP were elevated preoperatively. In the postoperative course both PCT and CrP reached peak-levels on day 2 with values up to 43.55 ng/ml and 384.00 mg/l, respectively. In PCT the rise was followed by a clear decrease in 20 (90.9 %) patients until day 7. In contrast the CrP levels decreased slowly and only seven (54.5%) patients had values of 100 mg/l or below on day 7. PCT showed a better correlation with the clinic in case of septic course than CrP does. Conclusions: PCT reflects postoperative clinical course more accurately than CrP. Therefore, PCT is a more appropriate laboratory parameter to monitor patients after surgery for pleural empyema. #

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“…Plasma concentrations have been shown to correlate with the severity of the infection [8,9]. Concentrations are significantly higher in patients with a systemic bacterial infection than in patients with a localized bacterial or viral infection [10,11]. PCT concentration has been demonstrated to discriminate between septic complications and noninfectious, inflammatory reactions in critically ill patients, as well as between transplant rejection and infection in organ recipients [11,12].…”

mentioning

confidence: 99%

Utility of Procalcitonin Concentration in the Evaluation of Patients with Malignant Diseases and Elevated C-Reactive Protein Plasma Concentrations

Schüttrumpf¹,

Binder²,

Hagemann³

et al. 2006

Clinical Infectious Diseases

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Procalcitonin (PCT) in cardiac surgery: diagnostic value in systemic inflammatory response syndrome (SIRS), sepsis and after heart transplantation (HTX)

Cited by 47 publications

References 8 publications

Pro-inflammatory cytokines after different kinds of cardio-thoracic surgical procedures: is what we see what we know?

Pro-inflammatory cytokines after different kinds of cardio-thoracic surgical procedures: is what we see what we know?

Comparison of procalcitonin and CrP in the postoperative course after lung decortication

Utility of Procalcitonin Concentration in the Evaluation of Patients with Malignant Diseases and Elevated C-Reactive Protein Plasma Concentrations

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