Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro

Nijsten, Mwn; Olinga, Peter; Vries, Elisabeth G.E. de; Groothuis, Gmm; Limburg, P. C.; Duis, HJ ten; Moshage, Han; Hoekstra, HJ; Bijzet, Johan; Zwaveling, JH; Koops, Heimen Schraffordt

doi:10.1097/00003246-200002000-00028

Cited by 260 publications

(178 citation statements)

References 13 publications

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“…Moreover, the markers that have been recently introduced into clinical practice are associated with high costs that serve as major limitations. These markers include PCT, which is considered a fast and specific marker for infection in critically ill patients and is currently implemented in routine diagnostic panels [9,10]. Conversely, the NLCR is a low-cost and easily obtainable parameter that does not require any special equipment for NLCR measurements.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil to lymphocyte count ratio as a biomarker of bacterial infections

et al. 2012

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AbstractThe implementation of new markers of bacterial infection into clinical practice is hindered by their costs. We assessed the potential use of the neutrophil to lymphocyte count ratio (NLCR) to discriminate between bacterial and viral infections. NLCR was evaluated in 45 patients with bacterial infections: 24 patients with viral infections and 18 healthy adults. The medians of NLCR were 11.73 in bacterial infections, 2.86 in viral infections and 1.86 in controls. The NLCR cut-off value of 6.2 exhibited a sensitivity value of 0.91 and a specificity value of 0.96 for bacterial infection. These results suggest a diagnostic potential for NLCR.

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Section: Discussionmentioning

confidence: 99%

Neutrophil to lymphocyte count ratio as a biomarker of bacterial infections

et al. 2012

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“…[2][3][4] Recent publications suggest an even higher diagnostic value of procalcitonin (PCT). [4][5][6][7][8] However, there are sporadic reports on high PCT levels in adult patients after T-cell antibody infusion following kidney transplantation with no evidence of infection. [9][10][11] To further investigate these observations, we analysed the characteristics of PCT and CRP serum levels in paediatric patients with haematological or oncological diseases during treatment with T-cell antibodies and compared these with those occurring with episodes of Gram-negative sepsis.…”

mentioning

confidence: 99%

Procalcitonin and C-reactive protein do not discriminate between febrile reaction to anti-T-lymphocyte antibodies and Gram-negative sepsis

Dornbusch

Strenger

Kerbl

et al. 2003

Bone Marrow Transplant

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Summary:Treatment with antibodies against T-lymphocytes usually triggers a febrile response potentially mimicking or masking infection. Procalcitonin (PCT) is considered a sensitive and specific marker of systemic bacterial and fungal infection. It was the aim of this study to investigate the characteristics of PCT and C-reactive protein (CRP) during treatment with polyclonal or monoclonal anti-Tcell antibodies, in order to examine the ability of these parameters to distinguish between systemic bacterial infection and reaction to antibody treatment. Thus, 15 consecutive febrile episodes after T-cell antibody infusion without clinical signs of infection were compared with nine episodes of Gram-negative sepsis. After T-cell antibody infusion PCT and CRP serum levels increased to a similar extent as in Gram-negative sepsis. Therefore, during T-cell antibody treatment neither PCT nor CRP are adequate for differentiating between fever due to infection or to unspecific cytokine release. Bone Marrow Transplantation (2003) 32, 941-945.

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“…13 Thus, during severe bacterial infections, the level of PCT may rise several hundred-folds and may even reach a level of 1000 ng/mL without any change in serum calcitonin level. 11,14 However, it is important to keep in mind the following situations while interpreting PCT reports: (i) Gram negative bacteraemias cause higher elevation of PCT than those caused by Gram positive pathogens; 15 (ii) there is a low or negligible rise in PCT levels in localized infections, and in infections caused by viruses or intracellular bacteria; 16,17 and (iii) in the neonatal period, particularly in the first 48-72 hours of life, serum PCT levels increase to a high level and then gradually fall during the first week. This is possibly due to initial establishment of gut flora.…”

Section: Procalcitonin: Structure and Synthesismentioning

confidence: 99%

Procalcitonin in sepsis and bacterial infections

Chaudhury¹,

Sumant²,

Jayaprada³

et al. 2013

JCSR

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The differentiation of sepsis and systemic bacterial infections from other causes of systemic inflammatory response is crucial from the therapeutic point of view. The clinical signs and symptoms are non-specific and traditional biomarkers like white cell count, erythrocyte sedimentation rate and C-reactive protein are not sufficiently sensitive or specific to guide therapeutic decisions. Procalcitonin (PCT) is considered a reliable marker for the diagnosis and prognosis of moderate to severe bacterial infections, and it has also been evaluated to guide the clinicians in the rational usage of antibiotics. This review describes the diagnostic and prognostic role of PCT as a biomarker in various clinical settings along with the laboratory aspects and its usefulness in risk stratification and antibiotic stewardship.

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Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro

Cited by 260 publications

References 13 publications

Neutrophil to lymphocyte count ratio as a biomarker of bacterial infections

Neutrophil to lymphocyte count ratio as a biomarker of bacterial infections

Procalcitonin and C-reactive protein do not discriminate between febrile reaction to anti-T-lymphocyte antibodies and Gram-negative sepsis

Procalcitonin in sepsis and bacterial infections

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