Probucol Slows the Progression of Cataracts in Streptozotocin-Induced Hyperglycemic Rats

Higashi, Kentaro; Mori, Akira; Sakamoto, Kenji; Ishii, Kunio; Nakahara, Tsutomu

doi:10.1159/000496055

Cited by 4 publications

(2 citation statements)

References 36 publications

(56 reference statements)

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“…This suggests that, due to the oxidative stress, protein aggregates were formed in the lenses of these animals. Similar results were obtained by other authors [51,58,59].…”

Section: Discussionsupporting

confidence: 92%

Chrysin Reduces Oxidative Stress but Does Not Affect Polyol Pathway in the Lenses of Type 1 Diabetic Rats

et al. 2020

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Prolonged hyperglycemia is one of the main causes of reactive oxygen species and free radicals generation in diabetes which may affect various organs, including the eye. Oxidative damage to proteins and lipids in the eye lens could lead to cataract formation. To cope with oxidative stress, the endogenous antioxidative system may be supported by the supplementation of exogenous antioxidants. The aim of this study was to evaluate the effect of chrysin, a natural flavonoid, on oxidative stress and polyol pathway-related markers in the lenses of streptozotocin-induced type 1 male diabetic rats. Chrysin at doses of 50 and 100 mg/kg was administered by gavage for 28 days. This treatment resulted in a decrease in antioxidative enzymes activity and oxidative stress index. Moreover, chrysin administration elevated the reduced glutathione level in the lenses. A decrease in the markers linked to oxidative damage to proteins and lipids in the lenses was noted, especially after treatment with 50 mg/kg of chrysin. Neither of the chrysin doses affected glycemia-related markers in the serum or altered parameters related to the polyol pathway and advanced glycation end-products level in the lenses of diabetic rats. Upon obtaining results, it can be concluded that chrysin reveals antioxidative activity in the lenses but shows no antihyperglycemic or antiglycation properties.

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“…This suggests that, due to the oxidative stress, protein aggregates were formed in the lenses of these animals. Similar results were obtained by other authors [51,58,59].…”

Section: Discussionsupporting

confidence: 92%

Chrysin Reduces Oxidative Stress but Does Not Affect Polyol Pathway in the Lenses of Type 1 Diabetic Rats

et al. 2020

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“…RT reduced the higher content of protein carbonyl and sorbitol in the lenses of diabetic rats. These outcomes beautifully protect the oxidative destruction to lens tissue proteins which are partially dedicated to an anti-cataract property of RC 22,23 .…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Rutaecarpine in Streptozotocin-Induced Diabetes Cataracts Through the Inhibition of Aldose Reductase Activity in Male Albino Rats

Chen¹,

Zhang²,

Liu³

et al. 2023

International J. of Pharmacology

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Background and Objective: Diabetes mellitus (DM) is a major metabolic disease which affect the millions of people worldwide. The DM induces the several associate diseases like cataract, renal and hepatic failure. The main enzyme aldose reductase during the polyol pathway serves an important part in the formation of cataracts in diabetic conditions. Rutaecarpine (RT), which is an indolopyridoquinazoline alkaloid and principal compound of evodia shows therapeutic activity against several chronic illnesses. It is proven to be effective in the treatment of diabetes mellitus via altering oxidative stress and inflammation. The goal of current research was to scrutinize the pharmacological action of rutaecarpine in streptozotocin-induced diabetic cataracts in rodents. Materials and Methods: All the animals were divided into five groups and streptozotocin-induced diabetic rats were supplemented with different doses of rutaecarpine. The formation of cataracts was evaluated using the scoring technique by observer and lens digital picture. Other biochemical parameters were also assessed such as blood, insulin, blood glucose, body weight, sorbitol content, protein carbonyl content, mRNA and expression of aldose reductase in each group of rats. We also measured the kinetics properties of aldose reductase. Results: Administration of rutaecarpine alters all biochemical parameters compared to diabetic cataract rats. Rutaecarpine significantly stuck the formation of cataracts in the rats in a dose-dependent manner. The kinetic properties of aldose reductase i.e., V max , K m and K i had also attenuated in diabetic cataract rats as well as mRNA and protein expression. Conclusion: Collectively, we can say that rutaecarpine has the potential to reduce the progression of cataracts in a diabetic case via the reduction of aldose reductase.

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Therapeutic effect of Keap1-Nrf2-ARE pathway-related drugs on age-related eye diseases through anti-oxidative stress

Cai

Liu

et al. 2021

Int J Ophthalmol

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Age-related eye diseases, including cataract, glaucoma, diabetic retinopathy (DR), and age-related macular degeneration (AMD), are the leading causes of vision loss in the world. Several studies have shown that the occurrence and development of these diseases have an important relationship with oxidative stress in the eye. The Keap1-Nrf2-ARE pathway is a classical pathway that resists oxidative stress and inflammation in the body. This pathway is also active in the development of age-related eye diseases. A variety of drugs have been shown to treat age-related eye diseases through the Keap1-Nrf2-ARE (Kelch-like ECH-Associating protein 1- nuclear factor erythroid 2 related factor 2-antioxidant response element) pathway. This review describes the role of oxidative stress in the development of age-related eye diseases, the function and regulation of the Keap1-Nrf2-ARE pathway, and the therapeutic effects of drugs associated with this pathway on age-related eye diseases.

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Probucol Slows the Progression of Cataracts in Streptozotocin-Induced Hyperglycemic Rats

Cited by 4 publications

References 36 publications

Chrysin Reduces Oxidative Stress but Does Not Affect Polyol Pathway in the Lenses of Type 1 Diabetic Rats

Chrysin Reduces Oxidative Stress but Does Not Affect Polyol Pathway in the Lenses of Type 1 Diabetic Rats

Protective Effect of Rutaecarpine in Streptozotocin-Induced Diabetes Cataracts Through the Inhibition of Aldose Reductase Activity in Male Albino Rats

Therapeutic effect of Keap1-Nrf2-ARE pathway-related drugs on age-related eye diseases through anti-oxidative stress

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