Probiotics for preventing preterm labour

Normal vaginal flora, disorders and application of probiotics in pregnancy

“…To our knowledge, the present study is the Wrst that investigated the eVectiveness of vaginal administration of Lactobacillus rhamnosus in preventing the development of abnormal vaginal Xora during pregnancy and extended the observation of the eVects on parameters whose alterations are considered relevant to increased vulnerability to preterm delivery [34].…”

Normal vaginal flora, disorders and application of probiotics in pregnancy

“…To our knowledge, the present study is the Wrst that investigated the eVectiveness of vaginal administration of Lactobacillus rhamnosus in preventing the development of abnormal vaginal Xora during pregnancy and extended the observation of the eVects on parameters whose alterations are considered relevant to increased vulnerability to preterm delivery [34].…”

Preterm Birth: A Narrative Review of the Current Evidence on Nutritional and Bioactive Solutions for Risk Reduction

“…The main probiotic milks available in Norway at that time contained Lactobacillus acidophilus LA-5, B. lactis Bb12, and L. rhamnosus GG. Regarding systematic reviews and meta-analyses, a 2007 Cochrane review on the efficacy of probiotics for preventing preterm labor [151] concluded that there were insufficient data as only one study with PTB as an outcome (not primary) was found [146]. The review was updated in 2010 with unchanged conclusions.…”

Through the Microbial Looking Glass: Premature Labor, Preeclampsia, and Gestational Diabetes

“…At least 30% of premature labors are associated with maternal infection. 35,84,89,90 Microbial pathogens can reach the uterine cavity through three routes that can lead to infection: (a) ascending from the vagina and cervix, (b) retrograde seeding from the abdominal cavity through the fallopian tubes, and (c) hematogenous seeding through the placenta. 89 At the level of the maternal mucosal surface, some microorganisms secrete phospholipase A2 that acts on phospholipids to form arachidonic acid, which ultimately converts to prostaglandins (PG, PGE2, PGF2A).…”

“…Bacterial Vaginosis is a microbial dysbiosis associated with a 40% increase in the risk of PTB. 35 When BV occurs there is a shift from a predominance of Lactobacilli populations to a higher proportion of other organisms: Gardnerella vaginalis , Pevotella bivia , Mobiluncus sp ., Mycoplasma hominis , and Atopobium vaginae. 85 This results in the characteristic vaginal secretions with a number of common clinical findings, including: pH ≥ 5.5, presence of clue cells, and positive whiff test.…”

“…Two systematic reviews and four clinical studies explored the efficacy of probiotic interventions to reduce PTB risk. Othman et al 35 conducted a systematic review of probiotic interventions to prevent premature labor. Three studies met their inclusion criteria; the impact of probiotic interventions on vaginal infection was based on two trials including a total of 99 participants.…”

Normal vaginal flora, disorders and application of probiotics in pregnancy

“…To our knowledge, the present study is the Wrst that investigated the eVectiveness of vaginal administration of Lactobacillus rhamnosus in preventing the development of abnormal vaginal Xora during pregnancy and extended the observation of the eVects on parameters whose alterations are considered relevant to increased vulnerability to preterm delivery [34].…”

Preterm Birth: A Narrative Review of the Current Evidence on Nutritional and Bioactive Solutions for Risk Reduction

“…The main probiotic milks available in Norway at that time contained Lactobacillus acidophilus LA-5, B. lactis Bb12, and L. rhamnosus GG. Regarding systematic reviews and meta-analyses, a 2007 Cochrane review on the efficacy of probiotics for preventing preterm labor [151] concluded that there were insufficient data as only one study with PTB as an outcome (not primary) was found [146]. The review was updated in 2010 with unchanged conclusions.…”

Through the Microbial Looking Glass: Premature Labor, Preeclampsia, and Gestational Diabetes

“…At least 30% of premature labors are associated with maternal infection. 35,84,89,90 Microbial pathogens can reach the uterine cavity through three routes that can lead to infection: (a) ascending from the vagina and cervix, (b) retrograde seeding from the abdominal cavity through the fallopian tubes, and (c) hematogenous seeding through the placenta. 89 At the level of the maternal mucosal surface, some microorganisms secrete phospholipase A2 that acts on phospholipids to form arachidonic acid, which ultimately converts to prostaglandins (PG, PGE2, PGF2A).…”

“…Bacterial Vaginosis is a microbial dysbiosis associated with a 40% increase in the risk of PTB. 35 When BV occurs there is a shift from a predominance of Lactobacilli populations to a higher proportion of other organisms: Gardnerella vaginalis , Pevotella bivia , Mobiluncus sp ., Mycoplasma hominis , and Atopobium vaginae. 85 This results in the characteristic vaginal secretions with a number of common clinical findings, including: pH ≥ 5.5, presence of clue cells, and positive whiff test.…”

“…Two systematic reviews and four clinical studies explored the efficacy of probiotic interventions to reduce PTB risk. Othman et al 35 conducted a systematic review of probiotic interventions to prevent premature labor. Three studies met their inclusion criteria; the impact of probiotic interventions on vaginal infection was based on two trials including a total of 99 participants.…”

Normal vaginal flora, disorders and application of probiotics in pregnancy

“…To our knowledge, the present study is the Wrst that investigated the eVectiveness of vaginal administration of Lactobacillus rhamnosus in preventing the development of abnormal vaginal Xora during pregnancy and extended the observation of the eVects on parameters whose alterations are considered relevant to increased vulnerability to preterm delivery [34].…”

Preterm Birth: A Narrative Review of the Current Evidence on Nutritional and Bioactive Solutions for Risk Reduction

“…The main probiotic milks available in Norway at that time contained Lactobacillus acidophilus LA-5, B. lactis Bb12, and L. rhamnosus GG. Regarding systematic reviews and meta-analyses, a 2007 Cochrane review on the efficacy of probiotics for preventing preterm labor [151] concluded that there were insufficient data as only one study with PTB as an outcome (not primary) was found [146]. The review was updated in 2010 with unchanged conclusions.…”

Through the Microbial Looking Glass: Premature Labor, Preeclampsia, and Gestational Diabetes

“…At least 30% of premature labors are associated with maternal infection. 35,84,89,90 Microbial pathogens can reach the uterine cavity through three routes that can lead to infection: (a) ascending from the vagina and cervix, (b) retrograde seeding from the abdominal cavity through the fallopian tubes, and (c) hematogenous seeding through the placenta. 89 At the level of the maternal mucosal surface, some microorganisms secrete phospholipase A2 that acts on phospholipids to form arachidonic acid, which ultimately converts to prostaglandins (PG, PGE2, PGF2A).…”

“…Bacterial Vaginosis is a microbial dysbiosis associated with a 40% increase in the risk of PTB. 35 When BV occurs there is a shift from a predominance of Lactobacilli populations to a higher proportion of other organisms: Gardnerella vaginalis , Pevotella bivia , Mobiluncus sp ., Mycoplasma hominis , and Atopobium vaginae. 85 This results in the characteristic vaginal secretions with a number of common clinical findings, including: pH ≥ 5.5, presence of clue cells, and positive whiff test.…”

“…Two systematic reviews and four clinical studies explored the efficacy of probiotic interventions to reduce PTB risk. Othman et al 35 conducted a systematic review of probiotic interventions to prevent premature labor. Three studies met their inclusion criteria; the impact of probiotic interventions on vaginal infection was based on two trials including a total of 99 participants.…”