Probiotics enhance the clearance of human papillomavirus-related cervical lesions

Verhoeven, Véronique; Renard, Nathalie; Makar, Amin; Royen, Paul Van; Bogers, Johannes; Lardon, Filip; Peeters, Marc; Baay, Marc

doi:10.1097/cej.0b013e328355ed23

Cited by 96 publications

(76 citation statements)

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“…After 6 months, the probiotic users had double the chance of clearance of cytological abnormalities (60% vs. 31% in women who received no treatment, p = 0.05). Additionally, HPV was cleared in 29% of probiotic users and only 19% of control patients, although not significant (p = 0.41) [80]. These results suggest that probiotics may play a role in promoting the clearance of HPV, although the mechanism is unknown.…”

Section: Referencesmentioning

confidence: 89%

“…However, it is important to note that the effects of bacteria on cultured cells may not accurately approximate the effects of probiotics on cells in vivo, therefore more research is needed in this area. In the third study, 54 women with HPV + low-grade squamous intraepithelial lesions were monitored for 6 months; the intervention group consumed a daily probiotic drink containing Lactobacillus casei, while the control group received no treatment [80]. After 6 months, the probiotic users had double the chance of clearance of cytological abnormalities (60% vs. 31% in women who received no treatment, p = 0.05).…”

Section: Referencesmentioning

confidence: 97%

“…Host factors that may impact the microbiome composition, including ethnic and/or socioeconomic diversity, will also be important for addressing health disparities related to cancer. Most clinical trials to date have focused on the efficacy of probiotics for reducing GI symptoms in gynecologic cancer patients [63,64,66,78,80,86,87], but there is little research on vaginal symptoms or the microbiota. Additional clinical trials will be useful for determining the efficacy of these agents for reducing GI and vaginal symptoms and whether they should be recommended for symptom management in gynecologic cancer patients.…”

Section: Future Perspectivesmentioning

confidence: 99%

See 2 more Smart Citations

The vaginal and gastrointestinal microbiomes in gynecologic cancers: A review of applications in etiology, symptoms and treatment

Chase

Goulder

Zenhausern

et al. 2015

Gynecologic Oncology

112

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Section: Referencesmentioning

confidence: 89%

Section: Referencesmentioning

confidence: 97%

Section: Future Perspectivesmentioning

confidence: 99%

See 1 more Smart Citation

The vaginal and gastrointestinal microbiomes in gynecologic cancers: A review of applications in etiology, symptoms and treatment

Chase

Goulder

Zenhausern

et al. 2015

Gynecologic Oncology

112

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“…A study involving 54 women reported that daily probiotic consumption for 6 months enhanced the clearance of human papillomavirus, which is known to cause cervical cancer [54]. In animal models, oral probiotic administration protects against Salmonella typhimurium infection by activating the phagocytic and microbicidal activity of peritoneal and spleen macrophages [55].…”

Section: Mechanisms Induced By Probiotics To Stimulate the Immune Systemmentioning

confidence: 99%

Beneficial Effects of Probiotic Consumption on the Immune System

Galdeano¹,

Cazorla²,

Dumit³

et al. 2019

Ann Nutr Metab

513

219

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Background: The gastrointestinal tract is one of the most microbiologically active ecosystems that plays a crucial role in the working of the mucosal immune system (MIS). In this ecosystem, the consumed probiotics stimulate the immune system and induce a network of signals mediated by the whole bacteria or their cell wall structure. This review is aimed at describing the immunological mechanisms of probiotics and their beneficial effects on the host. Summary: Once administered, oral probiotic bacteria interact with the intestinal epithelial cells (IECs) or immune cells associated with the lamina propria, through Toll-like receptors, and induce the production of different cytokines or chemokines. Macrophage chemoattractant protein 1, produced by the IECs, sends signals to other immune cells leading to the activation of the MIS, characterized by an increase in immunoglobulin A⁺ cells of the intestine, bronchus and mammary glands, and the activation of T cells. Specifically, probiotics activate regulatory T cells that release IL-10. Interestingly, probiotics reinforce the intestinal barrier by an increase of the mucins, the tight junction proteins and the Goblet and Paneth cells. Another proposed mechanism of probiotics is the modulation of intestinal microbiota by maintaining the balance and suppressing the growth of potential pathogenic bacteria in the gut. Furthermore, it has been demonstrated that long-term probiotics consumption does not affect the intestinal homeostasis. The viability of probiotics is crucial in the interaction with IECs and macrophages favoring, mainly, the innate immune response. Macrophages and Dendritic cells (DCs) play an important role in this immune response without inducing an inflammatory pattern, just a slight increase in the cellularity of the lamina propria. Besides, as part of the machinery that probiotics activate to protect against different pathogens, an increase in the microbicidal activity of peritoneal and spleen macrophages has been reported. In malnutrition models, such as undernourishment and obesity, probiotic was able to increase the intestinal and systemic immune response. Furthermore, probiotics contribute to recover the histology of both the intestine and the thymus damaged in these conditions. Probiotic bacteria are emerging as a safe and natural strategy for allergy prevention and treatment. Different mechanisms such as the generation of cytokines from activated pro-T-helper type 1, which favor the production of IgG instead of IgE, have been proposed. Key Messages: Probiotic bacteria, their cell walls or probiotic fermented milk have significant effects on the functionality of the mucosal and systemic immune systems through the activation of multiple immune mechanisms.

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“…A pilot study suggested that probiotic promotes the clearance of HPV-related cytological abnormalities [95] . Common vaginal lactobacilli exerted cytotoxic effects on cervical tumour cells independently of pH and lactate [96] .…”

Section: Nutrtion and Breast Cancermentioning

confidence: 99%