Probiotics and Prebiotics Having Broad Spectrum Anticancer Therapeutic Potential: Recent Trends and Future Perspectives

Sharma, Varruchi; Sharma, Nitin; Sheikh, Imran; Kumar, Vikas; Sehrawat, Nirmala; Yadav, Mukesh; Ram, Gobind; Sankhyan, Atul; Sharma, Anil Kumar

doi:10.1007/s40495-021-00252-x

Cited by 24 publications

(16 citation statements)

References 101 publications

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“…Upon structure modelling, Model-1 has proven to be the best model. The results generated are in agreement with other studies reported in the literature, which prove the geometry and stereochemistry checks also along with the energy distribution using PROCHECK (Sharma et al 2021b). The values obtained using the tool are following the studies reported in the literature.…”

Section: Resultssupporting

confidence: 91%

“…PI3K/Akt/mTOR pathway being a complex intracellular pathway is known to result in cell growth and tumor proliferation, and thus it could act as a striking target for anticancer drug development (Sharma, 2020(Sharma, , 2022. Growth factors binding to the receptors activate PI3K, resulting in phosphorylation of the PI3-K-dependent kinases, which trigger AKT (Sharma et al 2021b). AKT further triggers mTOR by phosphorylation and inhibition of TSC2, which negatively regulates mTOR.…”

Section: Introductionmentioning

confidence: 99%

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In-silico designing of an inhibitor against mTOR FRB domain: Therapeutic implications against breast cancer

Sharma¹,

Sharma

Panwar

et al. 2022

J Exp Bio & Ag Sci

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Worldwide breast cancer causes significant fatalities in women. The effective therapeutic solution for treating the disease is using new and probable antagonistic biologically available ligands as anticancer drugs. To identify a successful therapeutic approach, the scientific community is now interested in creating novel ligands that in the future may be used as anticancer drugs. The mechanistic target of rapamycin (mTOR) is a protein kinase connected to several processes governing immunity, metabolism, cell development, and survival. The proliferation and metastasis of tumors have both been linked to the activation of the mTOR pathway. Female breast cancer represents about 15.3% of all new cancer cases in the U.S. alone and is frequently diagnosed among women aged 55 to 69 years. Given that the P13K/AKT/mTOR pathway is one of the most often activated in cancer, much attention has been paid to its resistance as a novel oncological treatment approach. mTOR/FRB Domain’s recruitment cleft as, well as substrate recruitment mechanism, was targeted using a structural-based approach. A series of selective inhibitory small molecules have been designed and screened for the best inhibiting target binding triad of the FRB Domain with better ADME and no detectable toxic effects.

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Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

In-silico designing of an inhibitor against mTOR FRB domain: Therapeutic implications against breast cancer

Sharma¹,

Sharma

Panwar

et al. 2022

J Exp Bio & Ag Sci

Self Cite

View full text Add to dashboard Cite

show abstract

“…NMR-based metabolomics provides a tool to unveil how gut-modulating foods (e.g., prebiotics and dietary fibers) affect the generation of some unfavorable gut-derived metabolites such as TMAO. Epidemiological data point at negative effects of red and processed meat intake on colon and host health, potentially associated with the microbiota-derived unfavorable metabolites [ 81 ]. However, metabolomics research has revealed that associations between meat intake and formation of unfavorable metabolites are complex and dependent on meal/diet composition.…”

Section: Gut Modulating Foods In the Suppression Of Unfavorable Metab...mentioning

confidence: 99%

NMR-Based Metabolomics to Decipher the Molecular Mechanisms in the Action of Gut-Modulating Foods

Bertram

2022

Foods

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Metabolomics deals with uncovering and characterizing metabolites present in a biological system, and is a leading omics discipline as it provides the nearest link to the biological phenotype. Within food and nutrition, metabolomics applied to fecal samples and bio-fluids has become an important tool to obtain insight into how food and food components may exert gut-modulating effects. This review aims to highlight how nuclear magnetic resonance (NMR)-based metabolomics in food and nutrition science may help us get beyond where we are today in understanding foods’ inherent, or added, biofunctionalities in relation to gut health.

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“…Probiotics are known as important micro-organisms that are used to improve intestinal health, including beneficial micro-organisms known to retard the production of bacterial enzymes that cause colon cancers [80]. Colonic microflora is very important for human health [81].…”

Section: Improvement Of Intestinal Health Through Probioticsmentioning

confidence: 99%

Nutritional and Health Potential of Probiotics: A Review

et al. 2021

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Several products consist of probiotics that are available in markets, and their potential uses are growing day by day, mainly because some strains of probiotics promote the health of gut microbiota, especially Furmicutes and Bacteroidetes, and may prevent certain gastrointestinal tract (GIT) problems. Some common diseases are inversely linked with the consumption of probiotics, i.e., obesity, type 2 diabetes, autism, osteoporosis, and some immunological disorders, for which the disease progression gets delayed. In addition to disease mitigating properties, these microbes also improve oral, nutritional, and intestinal health, followed by a robust defensive mechanism against particular gut pathogens, specifically by antimicrobial substances and peptides producing probiotics (AMPs). All these positive attributes of probiotics depend upon the type of microbial strains dispensed. Lactic acid bacteria (LAB) and Bifidobacteria are the most common microbes used, but many other microbes are available, and their use depends upon origin and health-promoting properties. This review article focuses on the most common probiotics, their health benefits, and the alleviating mechanisms against chronic kidney diseases (CKD), type 1 diabetes (T1D), type 2 diabetes (T2D), gestational diabetes mellitus (GDM), and obesity.

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Probiotics and Prebiotics Having Broad Spectrum Anticancer Therapeutic Potential: Recent Trends and Future Perspectives

Cited by 24 publications

References 101 publications

In-silico designing of an inhibitor against mTOR FRB domain: Therapeutic implications against breast cancer

In-silico designing of an inhibitor against mTOR FRB domain: Therapeutic implications against breast cancer

NMR-Based Metabolomics to Decipher the Molecular Mechanisms in the Action of Gut-Modulating Foods

Nutritional and Health Potential of Probiotics: A Review

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