Probing suitable therapeutic nanoparticles for controlled drug delivery and diagnostic reproductive health biomarker development

Jha, Rajib Kumar; Jha, Pradeep Kumar; Gupta, Santosh; Bhuvaneshwaran, S.P.; Hossain, Maidul; Guha, Sujoy K.

doi:10.1016/j.msec.2015.12.044

Cited by 10 publications

(5 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Three of the studies used sperm from healthy male volunteers: Aminzadeh et al (17) 1). These studies (11,12,16,17) were conducted in the US, India, Iran and Colombia; all of them agreed that sperm viability was not affected by nanotubes, NO was not significantly produced compared to control in any of the two studies evaluating it (11,17). Aminzadeh et al (17) found a correlation between nanotubes concentrations added to sperm and ROS production similar to Ashgar et al (11), which found an increase of ROS generation sperm.…”

Section: Resultsmentioning

confidence: 71%

“…Literature searches identified 340 documents, and 4 articles (11,12,16,17) were finally included after excluding duplicate studies, irrelevant literature, and review articles adhering strictly to the inclusion and exclusion criteria (Figure 1). Three of the studies used sperm from healthy male volunteers: Aminzadeh et al (17) 1).…”

Section: Resultsmentioning

confidence: 99%

“…Aminzadeh et al (17) found a correlation between nanotubes concentrations added to sperm and ROS production similar to Ashgar et al (11), which found an increase of ROS generation sperm. Jha et al (16) proved MWNTs can interact with and infiltrate sperm cells without causing cell damage. Their research reveals that MWNTs, compared to other nanoparticles, has markedly lower interaction rates with nucleic acids.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Effects of nanotubes on semen quality and fertility in humans: A systematic review of literature

Fernández Zapata,

Cardona Maya,

Isaza Merino

et al. 2024

Arch Ital Urol Androl

View full text Add to dashboard Cite

Background: In the medical field, it is increasingly common to observe the use of nanotubes, for example, in the administration of drugs. However, nanotubes raise concerns for male fertility due to potential effects on hormone levels and sperm quality observed in animal studies. In addition, animal exposure to multi-walled carbon nanotube models found alterations in hormone levels, sperm motility, and sperm count. Limited evidence in humans suggests no adverse effects, but further research is needed. This study aimed to perform a systematic review to assess the in vitro effects of nanotubes on semen and fertility in humans. Methods: We included all published in vitro studies about semen or sperm or male fertility and nanotubes in humans. A search was conducted in LILACS, PubMed, and SCOPUS as of May 2023. The risk of bias was assessed using the QUIN tool. Results: Four studies using nanotubes on human sperm were included, nanotubes exposure appears not to affect sperm viability; however, some alterations to motility, velocity and production of reactive oxygen species were reported. Limited evidence is provided because of the small quantity of publications. Conclusions: Nanotubes appear to have no adverse effects on human sperm.

show abstract

Section: Resultsmentioning

confidence: 71%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effects of nanotubes on semen quality and fertility in humans: A systematic review of literature

Fernández Zapata,

Cardona Maya,

Isaza Merino

et al. 2024

Arch Ital Urol Androl

View full text Add to dashboard Cite

show abstract

“…In the present analysis of research studies evidencing the effects of graphene and graphene derivatives on reproductive functions, the biggest problem that came to light, as mentioned above, was the nature and features of the investigated materials. As a matter of fact, the term graphene was often used as a general term to indicate carbon materials spanning from zero-dimensional carbon materials such as carbon black (CB) [ 41 ] and nanodiamonds (ND) [ 42 ], mono-dimensional carbon materials such as single walled (SWCNTs) and multiwalled carbon nanotubes (MWCNTs) [ 43 ]—that can be considered a rolled up form of single or few graphene sheets—and even bidimensional carbon materials such as graphene itself.…”

Section: Graphene Familymentioning

confidence: 99%

Graphene and Reproduction: A Love-Hate Relationship

et al. 2021

View full text Add to dashboard Cite

Since its discovery, graphene and its multiple derivatives have been extensively used in many fields and with different applications, even in biomedicine. Numerous efforts have been made to elucidate the potential toxicity derived from their use, giving rise to an adequate number of publications with varied results. On this basis, the study of the reproductive function constitutes a good tool to evaluate not only the toxic effects derived from the use of these materials directly on the individual, but also the potential toxicity passed on to the offspring. By providing a detailed scientometric analysis, the present review provides an updated overview gathering all the research studies focused on the use of graphene and graphene-based materials in the reproductive field, highlighting the consequences and effects reported to date from experiments performed in vivo and in vitro and in different animal species (from Archea to mammals). Special attention is given to the oxidized form of graphene, graphene oxide, which has been recently investigated for its ability to increase the in vitro fertilization outcomes. Thus, the potential use of graphene oxide against infertility is hypothesized here, probably by engineering the spermatozoa and thus manipulating them in a safer and more efficient way.

show abstract

“…GO is a carbon-based material characterized by extraordinary properties [8] that have received an increasing attention during the last years due to its interesting applications, extended for example from its use to renewable energy generation [9,10] to the biomedical field [11][12][13][14]. Moreover, it had been proposed previously the possibility that GO could exert a detrimental effect on the reproductive function of some animal models [15][16][17][18][19], in particular when spermatozoa are exposed to different GO forms [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide: A glimmer of hope for Assisted Reproductive Technology

Ramal-Sanchez

Valbonetti

Tsikis

et al. 2019

Carbon

View full text Add to dashboard Cite

Infertility is a worldwide problem affecting around 48.5 million couples in the word, the male factor being responsible for approximately the 50% of the cases, with a high percentage of unknown causes. For that reason, improving the success of In Vitro Fertilization (IVF) techniques is a primordial aim for researchers working in the reproductive field. Here, by using a mammalian animal model, the bovine, we present an innovative in vitro fertilization system that combines the use of a somatic component, the epithelial oviductal cells, and a carbon-based material, the graphene oxide, with the aim to open new ways in IVF systems design and application.Our results show an increase in the IVF outcomes without harming the blastocyst developmental rate, as well as high modified proteomic and lipidomic profiles of capacitating spermatozoa. Furthermore, we compared the modifications produced by GO with those exerted by the hormone progesterone, finding similar functional effects on sperm capacitation.In conclusion, our results stand out the use of a non-physiological material as graphene oxide in a new and innovative strategy that improves sperm capacitation, conferring them a higher fertilizing competence and thus increasing the in vitro fertilization outcomes.

show abstract

Probing suitable therapeutic nanoparticles for controlled drug delivery and diagnostic reproductive health biomarker development

Cited by 10 publications

References 52 publications

Effects of nanotubes on semen quality and fertility in humans: A systematic review of literature

Effects of nanotubes on semen quality and fertility in humans: A systematic review of literature

Graphene and Reproduction: A Love-Hate Relationship

Graphene oxide: A glimmer of hope for Assisted Reproductive Technology

Contact Info

Product

Resources

About