Abstract:Gaussian graphical models (GGMs), also known as Gaussian Markov random field (MRF) models, are commonly used for gene regulatory network construction. Most current approaches to estimating network structure via GGMs can be categorized into a binary decision that determines if an edge exists through penalized optimization and a probabilistic approach that incorporates graph uncertainty. Analyses in the first category usually adopt the perspective of variable (edge) selection without consideration of probabilist… Show more
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