Proanthocyanidins and human health: Systemic effects and local effects in the gut

Scalbert, Augustin; Déprez, Stéphanie; Mila, Isabelle; Albrecht, Anne-Marie; Huneau, Jean‐François; Rabot, Sylvie

doi:10.1002/biof.5520130119

Cited by 94 publications

(54 citation statements)

References 36 publications

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“…For also the results obtain in this report about it absorptionby in vitro and in situ models could be verify the report of other author in the field of absorption and bioavailability of polyphenols in animals and in human. Our found coincide by other report about the antiulcerogenic activity for some polyphenols [43]- [46].…”

Section: Discussionsupporting

confidence: 93%

Further Pharmacological Evidence Supporting the Development of an Antiulcerogenic Drug Based on Rhizophora mangle L. Aqueous Extract. HPLC Method Proposed for Determinating a Chemical Marker

Perera¹,

Piloto²,

Canelsota³

et al. 2016

OALib

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Rhizophora mangle L. is a vegetal species with high disponibility in Cuba for guarantying economical factibility by drug development. Preview studies showed promissory pharmacological results by the use of this plant in the treatment of gastroduodenal ulcers. The present work involved another evaluation of the active extract important by the development of a new drug. It was evaluated by intestinal absorption in vitro and in situ models and anti-diarrheic activity in rats. The polyphenolic fractions were separated from the aqueous extract and its cytoprotective activity was studied on gastric ulceration induced by ethanol plus hydrochloric acid in rats. Some toxicological studies were carried out. We made a validation of HPLC method by the analysis of one mark in the tablet development. The aqueous extract showed high absorption, and high anti-diarrheic effect. The low-molecular weight polyphenolic fraction showed the highest level of gastric protection. No toxicological signs were obtained by it. HPLC method evidenced linearity, precision, sensitivity and accuracy.

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Section: Discussionsupporting

confidence: 93%

Further Pharmacological Evidence Supporting the Development of an Antiulcerogenic Drug Based on Rhizophora mangle L. Aqueous Extract. HPLC Method Proposed for Determinating a Chemical Marker

Perera¹,

Piloto²,

Canelsota³

et al. 2016

OALib

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“…Those facts were previously discussed and widely confirmed by some authors. In fact, different reports have stated the benefits of hydrolysis, fermentation, dissolution and even mixture of different phenolic matrices in the improvement of polyphenols bioavailability and its biological potential (Dey & Kuhad, 2014;Fardet et al, 2008;Kountouri, Mylona, Kaliora, & Andrikopoulos, 2007;Pinelo, Landbo, Vikbjerg, & Meyer, 2006;Scalbert et al, 2000). But, extensive studies, which aim to understand the real interference of those methodologies on the improvement of phenolic matrices bioavailability, are significantly scarce.…”

Section: Zhao Et Al 2005)mentioning

confidence: 99%

In vivo antioxidant activity of phenolic compounds: Facts and gaps

Martins

Barros

Ferreira

2016

Trends in Food Science & Technology

265

159

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Background: Numerous diseases have been related with free radicals overproduction and oxidative stress. Botanical preparations possess a multitude of bioactive properties, including antioxidant potential, which has been mainly related with the presence of phenolic compounds. However, the mechanisms of action of these phytochemicals, in vivo effects, bioavailability and bio-efficacy still need research.Scope and Approach: The present report aims to provide a critical review on the aspects related with the in vivo antioxidant activity of phenolic extracts and compounds from plant origin.Key findings: Biological functions beyond the human metabolism were discussed, comparing in vivo vs. in vitro studies, as also focusing the conditioning factors for phenolic compounds bioavailability and bio-efficacy. Furthermore, an upcoming perspective about the use of phytochemicals as life expectancy promoters and anti-aging factors in human individuals was provided.Conclusions: Overall, and despite all of those advances, the study of the biological potential of numerous natural matrices still remains a hot topic among the scientific community. In fact, the available knowledge about the responsible phytochemicals for the biological potential, their mechanisms of action, the establishment of therapeutic and prophylactic doses, and even the occurrence of biochemical inter-relations, is considerable scarce.

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“…The ability of phenolic components to bind bivalent transition metals effectively reduces the concentration of these cations and thus the extent of their prooxidative activity. However, it has to be kept in mind that in vitro data of the antioxidant capacity do not tell much on the role they may play in vivo to prevent oxidative stress [76]. A few reports also describe an antioxidant effect in an animal model, where chokeberry anthocyanins decrease lipid peroxidation and enhance the activity of enzymes which are involved in the antioxidant defence system [77], [78], [79], [80].…”

Section: Antioxidant Effectsmentioning

confidence: 99%

Chokeberry(Aronia melanocarpa)– A Review on the Characteristic Components and Potential Health Effects

Kulling¹,

Rawel²

2008

Planta Med

451

458

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Botanical Background and Cultivation ! Aronia berries originate from the eastern parts of North America and East Canada [1], [2], [3]. Their migration to Europe occurred around 1900 via Germany to Russia and back. Around 1946 the plant was established as a cultivar in the former Soviet Union. More recently it is cultivated also in East European countries and Germany (Oberlausitz) [1], [2]. The genus name Aronia has been replacing the common name, chokeberry. Two species can be distinguished: Aronia melanocarpa [Michx.] Elliot (black chokeberry, Aronia noir) and Aronia arbutifolia [L.] Elliot (red chokeberry, Aronia rouge) [3]. A third entity is intermediate and has variously been considered a species (A. prunifolia), a variety of each of the other two, or a hybrid [3]. The other common names for Aronia besides chokeberries include black apple berry and rowanberries (Sorbus aucuparia L.), whereby in the latter case the hybrids of rowanberry with Aronia are likely to be addressed [4], [5], [6]. Aronia is a member of the Rosaceae family, and the cultivars used for fruit production are from the species Aronia melanocarpa [6], [7], [8], [9]. Cultivars have been bred for larger edible fruits and ornamental value. The plants have no known pest problems [10]. Some cultivars are bred of true black chokeberry (Aronia melanocarpa) and some are hybrid cultivars (e. g., Aronia x Sorbus) [5], [11]. The more important cultivars include "Nero" (Czechia), "Rubina" (crossing from Russian and Finnish plants), "Viking" (Finland), "Kurkumäcki" (Finland), "Hugin" (Sweden), "Fertödi" (Hungary) and "Aron" (Denmark) [2]. "Viking" and "Nero" are cultivars that are commonly available in North American plant catalogues [7]. The Aronia shrubs can grow to a height of 2-3 m, which produce in May to June umbels of some 30 small white flowers, ripening to bright red (red chokeberry) or to purplish black berries (black chokeberry; Ø 6-13 mm, 0.5-2 g) [1], [2], [8], [12]. Harvest is performed mechanically between August and September. Five to twelve tons per hectare can be expected in about five years, once plants have matured [7], [8]. The effect of fertiliser rate on fruit quality parameters in the black chokeberry showed that an increased fertiliser application results in increased growth and higher yield whereas pigment content and total acidity decreased. Maximum production of anthocyanins per plant was obtained with a medium high fertiliser rate (50 kg N/ha, 44 kg P/ha, 100 kg K/ ha) [13]. The content of undesirable brown compounds and that of desirable anthocyanins is also dependent on maturation as documented in [11]. A recent study illustrates that applied fertilization may exert a differential influence on the chemical composition of Aronia fruits especially with regard to sugar content and the quantity

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Proanthocyanidins and human health: Systemic effects and local effects in the gut

Cited by 94 publications

References 36 publications

Further Pharmacological Evidence Supporting the Development of an Antiulcerogenic Drug Based on Rhizophora mangle L. Aqueous Extract. HPLC Method Proposed for Determinating a Chemical Marker

Further Pharmacological Evidence Supporting the Development of an Antiulcerogenic Drug Based on Rhizophora mangle L. Aqueous Extract. HPLC Method Proposed for Determinating a Chemical Marker

In vivo antioxidant activity of phenolic compounds: Facts and gaps

Chokeberry(Aronia melanocarpa)– A Review on the Characteristic Components and Potential Health Effects

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