Pro-senescence therapy for hepatocellular carcinoma

Muehlich, Susanne; Gudermann, Thomas

doi:10.18632/aging.100601

Cited by 8 publications

(11 citation statements)

References 9 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cell senescence induction is a novel approach for HCC treatment. 55 Ganoderiol F induces cell senescence by activating the extracellular-signal-regulated kinase (ERK) pathway and up-regulating the expression of p16. 56 L. lucidum Ait.…”

Section: History Of Tcm For Hcc Prevention and Therapymentioning

confidence: 99%

Traditional Chinese medicine as supportive care for the management of liver cancer: Past, present, and future

Liao

Bu²,

Jia

2020

Genes & Diseases

View full text Add to dashboard Buy / Rent full text

Liver cancer is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide. Western medicine and therapies are the primary treatment strategies of hepatocellular carcinoma (HCC), but the general prognosis for HCC patients is still dismal. Under these circumstances, HCC prevention is particularly important. Traditional Chinese medicine (TCM) encompasses a wealth of documented therapeutic resources, and “preventative treatment” is the principle of TCM. In China, TCM has been used for HCC prevention for thousands of years, and has also been demonstrated to be effective for the treatment of HCC in modern China. However, the TCM theory for prevention and treatment of HCC is more widely accepted in China than abroad. In this review, we first summarize the herbs and ancient formulas with therapeutic effects on HCC. We also review the research status of TCM in modern medicine as well as the current obstacles in its development. Finally, we discuss the future of TCM in the context of precision and integrated medicine. After reviewing the literature, we believe that TCM, through ancient development, is an advanced method of cancer treatment with positive curative effects, despite its surrounding controversy. Furthermore, precise analyses and systematic research methods provides novel approaches to modernize TCM for the future.

show abstract

Section: History Of Tcm For Hcc Prevention and Therapymentioning

confidence: 99%

Traditional Chinese medicine as supportive care for the management of liver cancer: Past, present, and future

Liao

Bu²,

Jia

2020

Genes & Diseases

View full text Add to dashboard Buy / Rent full text

show abstract

“…Cell senescence is a stable, irreversible cell cycle arrest triggered by a variety of stimuli. Induction of senescence has been suggested as novel approach for HCC treatment [126]. Ganoderiol F, a tetracyclic triterpene from Ganoderma amboinense , activates ERK and up-regulates p16 to induce cell senescence in hepatoma HepG2 cells [96] (Figure 1, Table 2).…”

Section: Induction Of Cell Senescencementioning

confidence: 99%

Preventive and Therapeutic Effects of Chinese Herbal Compounds against Hepatocellular Carcinoma

Wang

et al. 2016

Molecules

View full text Add to dashboard Buy / Rent full text

Traditional Chinese Medicines, unique biomedical and pharmaceutical resources, have been widely used for hepatocellular carcinoma (HCC) prevention and treatment. Accumulated Chinese herb-derived compounds with significant anti-cancer effects against HCC have been identified. Chinese herbal compounds are effective in preventing carcinogenesis, inhibiting cell proliferation, arresting cell cycle, inducing apoptosis, autophagy, cell senescence and anoikis, inhibiting epithelial-mesenchymal transition, metastasis and angiogenesis, regulating immune function, reversing drug resistance and enhancing the effects of chemotherapy in HCC. This paper comprehensively reviews these compounds and their effects on HCC. Finally, the perspectives and rational application of herbal compounds for HCC management are discussed.

show abstract

“…Prosenescence has been suggested for hepatocellular carcinoma treatment [151] . We have established a liverYin tonifying formula (LYTF) for liverYindeficiency in patients with hepatocarcinoma.…”

Section: Induction Of Cell Senescencementioning

confidence: 99%

Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside

Wang

2015

WJH

View full text Add to dashboard Buy / Rent full text

and other TCM syndromes (Zheng). Modern treatments such as surgery, transarterial chemoembolization (TACE) and high intensity focus ultrasound treatment would influence the manifestation of TCM syndromes. Herbs with traditional efficacy of tonifying Qi, blood and Yin, soothing liver-Qi stagnation, clearing heat and detoxifying and dissolving stasis, have been demonstrated to be potent to prevent hepatocarcinogenesis. TCM has been widely used in all aspects of integrative therapy in hepatocarcinoma, including surgical resection, liver transplantation, TACE, local ablative therapies and even as monotherapy for middle-advanced stage hepatocarcinoma. Clinical practices have confirmed that TCM is effective to alleviate clinical symptoms, improve quality of life and immune function, prevent recurrence and metastasis, delay tumor progression, and prolong survival time in hepatocarcinoma patients. The effective mechanism of TCM against hepatocarcinoma is related to inducing apoptosis, autophagy, anoikis and cell senescence, arresting cell cycle, regulating immune function, inhibiting metastasis and angiogenesis, reversing drug resistance and enhancing effects of chemotherapy. Along with the progress of research in this field, TCM will contribute more to the prevention and treatment of hepatocarcinoma. AbstractTraditional Chinese medicine (TCM) has played a positive role in the management of hepatocarcinoma. Hepatocarcinoma patients may present Qi-stagnation, damp-heat, blood stasis, Qi-deficiency, Yin-deficiency REVIEWSubmit a

show abstract

Pro-senescence therapy for hepatocellular carcinoma

Cited by 8 publications

References 9 publications

Traditional Chinese medicine as supportive care for the management of liver cancer: Past, present, and future

Traditional Chinese medicine as supportive care for the management of liver cancer: Past, present, and future

Preventive and Therapeutic Effects of Chinese Herbal Compounds against Hepatocellular Carcinoma

Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside

Contact Info

Product

Resources

About