Pro-angiogenic activity of notoginsenoside R1 in human umbilical vein endothelial cells in vitro and in a chemical-induced blood vessel loss model of zebrafish in vivo

Yang, Bong Min; Hong, Si-Jia; Lee, Simon Ming‐Yuen; Cong, Weihong; Wan, Jian‐Bo; Zhang, Zherui; Zhang, Qingwen; Zhang, Yi; Wang, Yitao; Lin, Zhi‐Xiu

doi:10.1007/s11655-014-1954-8

Cited by 44 publications

(26 citation statements)

References 37 publications

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“…In another study,in vitrouses of HUVECs have been described as a major role in angiogenic activityof notoginsenoside R1 (R1), a mainsaponin found in Panaxnotoginseng. In this study, they showedthat R1 stimulates and markedly enhanced proliferation oftube formation ability of HUVECs [17].…”

Section: In Vitro Usage Of Huvecssupporting

confidence: 51%

Deneysel kardiyovasküler çalışmalarda insan umblikal ven endotel hücrelerinin önemi

Akbay¹

2019

Turkish Journal of Clinics and Laboratory

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Nowadays, cardiovascular system disorders caused by narrowing or obstruction of the vascular system lead to the most important diseases that have a negative effect on the quality of life and have fatal consequences. It is known that many diseases are accompanied by cardiovascular system disorders. For these reasons, studies on the existence of different pathways activated in cardiovascular pathology and the investigation of these pathways have come intoquestion, and in vitro methods have been needed to be developed. in vitro cell culture models are the preferred models to enable understanding the mechanisms that regulate the process of angiogenesis. Human umbilical vein endothelial cells (HUVEC) are one of the most common in vitrocell models used in vascular studies within the scope of cardiovascular pathology. This review focuses on the use of HUVECs as an in vitro model to evaluate different therapeutic approaches.

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Section: In Vitro Usage Of Huvecssupporting

confidence: 51%

Deneysel kardiyovasküler çalışmalarda insan umblikal ven endotel hücrelerinin önemi

Akbay¹

2019

Turkish Journal of Clinics and Laboratory

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“…Possible mechanisms may be related to its function of angiogenesis. Previous studies have proved the angiogenic effect of notoginsenoside R1 [16], ginsenoside Re [17, 18], and Rg1 [17, 19], which may explain the main active constituents of SG but that is not our aim to further clarify the role of these constituents of the present study.…”

Section: Discussionmentioning

confidence: 87%

Traditional Chinese Medicine ShenZhuGuanXin Granules Mitigate Cardiac Dysfunction and Promote Myocardium Angiogenesis in Myocardial Infarction Rats by Upregulating PECAM‐1/CD31 and VEGF Expression

Zou

Qiu

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Background Myocardial infarction (MI) is the main cause of global mortality and morbidity despite the development of therapeutic approaches. ShenZhuGuanXin granules (SG) have been shown to possess cardioprotective effects against coronary heart disease (CHD). However, little is known about its specific mechanism. The present study aimed to investigate the therapeutic effect of SG in cardiac dysfunction and to demonstrate whether SG can promote myocardium angiogenesis by establishing a rat model of myocardial infarction with left anterior descending ligating. Methods and Results Three days after MI, rats were randomly divided into six groups: sham group (sham), MI group (MI), MI + low dose SG (SG-L) group, MI + middle dose SG (SG-M) group, MI + high dose SG (SG-H) group, and MI + compound Danshen dropping pills (CDDP) group as a positive control. Four weeks after administration, rats underwent hemodynamics and echocardiography study. Ventricle tissues were processed for histology and immunohistochemistry studies. Compared with MI group, SG treatment dose-dependently improved cardiac hemodynamic function, attenuated infarct size, increased microvessel density, and increased the expression of PECAM-1/CD31 and VEGF. Conclusions SG dose-dependently improved cardiac hemodynamic function and attenuated infarct size by promoting angiogenesis through upregulating PECAM-1/CD31 and VEGF expression.

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“…Tanshinone-IIA and cryptotanshinone [28], Ginsenoside Rd. [29], notoginsenoside R1 [30], Aucubin [31] are responsible for the regulation of VEGF or P-ERK. The VEGF, P-ERK and Hippo signaling pathways could interact and contribute to the pathological process, so it has been proposed that some of the active constituents isolated from XST can collaborate to control retinal endothelial cell proliferation or migration and inhibit angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

The Hippo signaling pathway: a potential therapeutic target is reversed by a Chinese patent drug in rats with diabetic retinopathy

Hao

et al. 2017

BMC Complement Altern Med

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BackgroundThe Hippo signaling pathway is reported to be involved in angiogenesis, but the roles of the Hippo pathway in diabetic retinopathy have not been addressed. Fufang Xueshuantong Capsule has been used to treat diabetic retinopathy in China; however, the effect of Fufang Xueshuantong Capsule on the Hippo pathway has not been investigated.MethodsIn this study, diabetes was induced in Sprague-Dawley rats with intraperitoneal injection of streptozotocin. Twenty weeks later, Fufang Xueshuantong Capsule was administered for 12 weeks. When the administration ended, the eyes were isolated for western blot and immunohistochemistry analyses. The levels of P- mammalian sterile 20-like (MST), large tumor suppressor homolog (Lats), P- yes-associated protein (YAP), transcriptional co-activator with PDZ binding motif (TAZ) and TEA domain family members (TEAD) were measured.ResultsDiabetic rats had a decreased P-MST level in the inner plexiform layer and reduced expression of P-YAP in the photoreceptor layers of their eyes. In addition, diabetic rats displayed remarkable increases in Lats, TAZ and TEAD in their retinas. Furthermore, Fufang Xueshuantong Capsule restored the changes in the Hippo pathway.ConclusionsThe Hippo signaling pathway is important for the progression of diabetic retinopathy and will hopefully be a targeted therapeutic approach for the prevention of diabetic retinopathy.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-017-1678-3) contains supplementary material, which is available to authorized users.

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Pro-angiogenic activity of notoginsenoside R1 in human umbilical vein endothelial cells in vitro and in a chemical-induced blood vessel loss model of zebrafish in vivo

Cited by 44 publications

References 37 publications

Deneysel kardiyovasküler çalışmalarda insan umblikal ven endotel hücrelerinin önemi

Deneysel kardiyovasküler çalışmalarda insan umblikal ven endotel hücrelerinin önemi

Traditional Chinese Medicine ShenZhuGuanXin Granules Mitigate Cardiac Dysfunction and Promote Myocardium Angiogenesis in Myocardial Infarction Rats by Upregulating PECAM‐1/CD31 and VEGF Expression

The Hippo signaling pathway: a potential therapeutic target is reversed by a Chinese patent drug in rats with diabetic retinopathy

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