Principles of Autopsy Techniques, Immediate and Restricted Autopsies, and Other Special Procedures

Ludwig, Jürgen

doi:10.1007/978-1-59259-286-9_1

Cited by 11 publications

(6 citation statements)

References 14 publications

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“…The decline in autopsy rate and issues surrounding the retention of tissues and organs for diagnostic studies, teaching, and research has been the subject of much debate since the adverse publicity concerning autopsies and organ retention. 16 Parents should be provided with full information and not be coerced into accepting an autopsy examination. It is important that those advising them at such a sensitive time do not take what may be the superficially kinder route of avoiding detailed discussion about the autopsy.…”

Section: Resultsmentioning

confidence: 99%

Study of various congenital anomalies in fetal and neonatal autopsy

et al. 2015

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Background:The study of dead is to save the livings. The growing awareness that still births and infant mortalities are unable to reduction has led to a wide spread desire for more information regarding the cause of these deaths. Congenital malformations have become important cause of fetal and neonatal (perinatal) mortality in developed countries and would very soon be increasingly important determinants of fetal and neonatal mortality in developing countries like India. In spite of antenatal diagnostic modality still the fetal autopsy plays the vital role in the conformation as well as identification of congenital anomalies and also for the counseling of the parents, to prevent the fetal congenital anomalies in further pregnancies. This study was undertaken with the purpose of finding out cause of death during the perinatal period at government maternity hospital and pediatric department S.V.R.R.G.G.H. & S.V. medical college Tirupati, and to study the clinical and pathological findings (Gross & microscopic) in fetal and neonatal death. Methods: The present study of congenital anomalies in fetal and neonatal deaths was done at S.V. medical college, Tirupati, over a time period of 2 years from September 2008 to 2010 August. Consent for autopsy in requested compassionately, respectfully and fully informed. The present study included dead fetus and neonates with gestational age above 20 weeks of intra uterine life and within 7 days of post natal life. All fetuses of gestational age <20 weeks and all neonates above 7 days of age were excluded from the study. The study also obtained clearance from the ethical committee of the institution. Autopsy was performed by standard technique adopted by Edith L. Potter. External and internal findings followed by histopathological examination, and autopsy findings were compared with available ultrasound findings. Results: A total of 46 Autopsies performed, 40 (87%) were fetal deaths, 6 (13%) were early neonatal deaths. In a total of 46 fetuses, there were 13 male and 33 female babies. On external examination of 46 fetal and Neonatal (perinatal) deaths, 8 (17.39%) babies showed congenital malformation. On internal examination of the 46 fetal and Neonatal (perinatal) deaths, 4 babies showed internal congenital anomalies. A total of 46 anatomical and histopathologic examinations were done among fetal and neonatal (perinatal) deaths. Out of 13 autopsies on male babies, 2 had congenital malformation and 33 autopsies on female babies, 7 had congenital malformations. Congenital anomalies were commonest in the birth weight group of 1000-1500 grams accounting for 9 cases. Malformations of central nervous system (33.33%) were most common followed by musculoskeletal system (16.66%), genitourinary and respiratory system (8.33%) respectively. Conclusion: Most number of perinatal deaths occurred in low birth weight and preterm babies. Study of malformations greatly helpful in genetic counseling and prenatal diagnosis in successive pregnancies.

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Section: Resultsmentioning

confidence: 99%

Study of various congenital anomalies in fetal and neonatal autopsy

et al. 2015

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“…Dissecting the viscera: The Rokitansky methods of evisceration, the organs were removed together in a blocks [10]. Examination begins with the most posterior structures and moves anteriorly layer by layer.…”

Section: Research Articlementioning

confidence: 99%

Study on various congenital anomalies in fetal autopsy

2016

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Introduction: The study of dead is to save the livings. Congenital malformations have become important cause of fetal and neonatal (perinatal) mortality in developed countries and would very soon be increasingly important determinants of fetal mortality in developing countries like India. The fetal autopsy plays the vital role in the conformation, identification of congenital anomalies and also for the counselling of the parents, to prevent the fetal congenital anomalies in further pregnancies. This study was undertaken with the purpose of finding out cause of death during the perinatal period at government kilpauk medical college Chennai and to study the clinical and pathological findings in fetal death. Methods: The retrospective study of congenital anomalies in fetal deaths was done at government kilpauk medical college Chennai over a time period of 1 years from june 2015 to June 2016. The present study included dead fetus.autopsy was performed by standard technique. External and internal findings are followed by histopathological examination and autopsy findings were compared with available ultrasound findings. Results: A total of 7 Autopsies performed. , there were 4 male and 3 female babies. Two babies showed external malformation and five babies showed internal congenital anomalies. Congenital anomalies were commonest in the birth weight group of 100-800 grams. Malformations of central nervous system, cardiovascular system and abdomen were most common followed by genitourinary and musculoskeletal system respectively. Conclusion: Perinatal deaths occurred in low birth weight and preterm babies. Study of malformations greatly helpful in genetic counselling and prenatal diagnosis in successive pregnancies.

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“…The cases obtained were those whose autopsy had been requested by the attending physicians during the YF epidemic. The autopsies, including brain removal, followed established protocols [ 25 , 26 ] and were performed by a pathologist (FPF). Of these cases, 34 were men aged between 16 and 71 years, and four were women aged between 31 and 74 years old (mean age = 48.35 years).…”

Section: Methodsmentioning

confidence: 99%

Neuropathology of yellow fever autopsy cases

Frassetto

Rosemberg

2023

Trop Dis Travel Med Vaccines

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Background Yellow fever is a viral hemorrhagic fever caused by yellow fever virus, a mosquito-borne flavivirus. Despite an effective vaccine, major outbreaks continue to occur around the world. Even though it is not a proven neurotropic virus, neurological symptoms in more severe clinical forms are frequent. The understanding of this apparent paradox is still rarely addressed in literature. Methods The brains of thirty-eight patients with yellow fever confirmed by RT-PCR, who underwent autopsy, were analyzed morphologically to identify and characterize neuropathological changes. The data were compared with brains collected from individuals without the disease, as a control group. Both cases and controls were subdivided according to the presence or absence of co-concurrent septic shock, to exclude changes of the sepsis associated encephalopathy. To verify possible morphological differences between the yellow fever cases groups, between the control groups, and between the cases and the controls, we applied the statistical tests Fisher's exact test and chi-square, with p values < 0.05 considered statistically significant. Results All cases and controls presented, at least focally, neuropathological changes, which included edema, meningeal and parenchymal inflammatory infiltrate and hemorrhages, and perivascular inflammatory infiltrate. We did not find an unequivocal aspect of encephalitis. The only parameter that, after statistical analysis, can be attributed to yellow fever was the perivascular inflammatory infiltrate. Conclusions The neuropathological findings are sufficient to justify the multiple clinical neurologic disturbances detected in the YF cases. Since most of the parameters evaluated did not show statistically significant difference between cases and controls, an explanation for most of the neuropathological findings may be the vascular changes, consequent to shock induced endotheliopathy, associated with stimulation of the immune system inherent to systemic infectious processes. The statistical difference obtained in yellow fever cases regarding perivascular infiltrate can be can be explained by the immune activation inherent to the condition.

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Principles of Autopsy Techniques, Immediate and Restricted Autopsies, and Other Special Procedures

Cited by 11 publications

References 14 publications

Study of various congenital anomalies in fetal and neonatal autopsy

Study of various congenital anomalies in fetal and neonatal autopsy

Study on various congenital anomalies in fetal autopsy

Neuropathology of yellow fever autopsy cases

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