Primycin, a New Antibiotic

Valyi-Nagy, T; J, Uri; Szilágyi, I

doi:10.1038/1741105b0

Cited by 40 publications

(15 citation statements)

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“…The oldest known example of insect-actinobacteria symbiosis is the 1954 discovery of primycin, an approved drug (EBRIMYCIN). 32 Bacteria and other microbes in Nature live in communities. The same genera and different phylotypes interact not only with each other but also with their environment.…”

Section: New Natural Resourcesmentioning

confidence: 99%

Thoughts and facts about antibiotics: Where we are now and where we are heading

Bérdy¹

2012

J Antibiot

903

557

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The declining trends in microbial metabolite and natural products research and the refocusing of this research area are discussed. Renewing natural products research requires inexhaustible natural resources, as well as new genetic techniques and microbial sources, including endophytic microbes. The numbers of known bioactive metabolites are summarized according to their microbiological origin, biological activities and chemical structures. Synthetic and natural product-based libraries are also compared. Importantly, the wide range of microbial metabolite bioactivities, future trends and the importance of prioritizing natural products over synthetic compounds are emphasized.

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Section: New Natural Resourcesmentioning

confidence: 99%

Thoughts and facts about antibiotics: Where we are now and where we are heading

Bérdy¹

2012

J Antibiot

903

557

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“…The first member of this group of guanidine derivatives was primycin (144), isolated from cultures Streptomyces primycini originating from the intestinal tract and the faeces of wax moth larvae (Galeria melonella) (317). The first member of this group of guanidine derivatives was primycin (144), isolated from cultures Streptomyces primycini originating from the intestinal tract and the faeces of wax moth larvae (Galeria melonella) (317).…”

Section: Macrocyclic Lactone Antibioticsmentioning

confidence: 99%

Some Aspects of Guanidine Secondary Metabolites

Berlinck

1995

Fortschritte Der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

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“…Our previous study demonstrated that Saccharomonospora azurea SZMC 14600 strain has an enhanced ability to produce primycin, a non-polyene macrolide lactone antibiotic [11). This heat stable, organic solvent soluble antibiotic complex (A1, A2 and C1) was first described by Vályi-Nagy et al [18]. Primycin (primycin sulphate) is an active ingredient of Ebrimycin gel that has been successfully applied to prevent the bacterial infection of surface traumas and burned tissues.…”

Section: Introductionmentioning

confidence: 99%

Proteomic insight into the primycin fermentation process of Saccharomonospora azurea

Valasek

Kiss

Fodor

et al. 2016

Acta Biologica Hungarica

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Saccharomonospora azurea SZMC 14600 is a member of the family Pseudonocardiaceae exclusively used for industrial scale production of primycin a large 36-membered non-polyene macrolide lactone antibiotic belonging to the polyketide class of natural products. Even though maximum antibiotic yield has been achieved by empirically optimized two-step fermentation process, little is known about the molecular components and mechanisms underlying the efficient antibiotic production. In order to identify differentially expressed proteins (DEPs) between the pre-and main-fermentation stages of primycin, comparative 2D-PAGE experiments were performed. In total, 98 DEP spots were reproducibly detected, out of which four spots were excised from gels, and identified through MALDI-TOF/TOF mass spectrometry. Peptide mass fingerprint analysis revealed peptide matches to HicB antitoxin for the HicAB toxinantitoxin system (EHK86651), to a nucleoside diphosphate kinase regulator ((Ndk; EHK81899) and two other proteins with unknown function (EHK88946 and EHK86777).

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Primycin, a New Antibiotic

Cited by 40 publications

References 0 publications

Thoughts and facts about antibiotics: Where we are now and where we are heading

Thoughts and facts about antibiotics: Where we are now and where we are heading

Some Aspects of Guanidine Secondary Metabolites

Proteomic insight into the primycin fermentation process of Saccharomonospora azurea

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