Primer for nutritionists: Managing the side effects of antidepressants

Tarleton, Emily K.; Kennedy, Amanda; Daley, Christopher J. A.

doi:10.1016/j.clnesp.2016.05.004

Cited by 10 publications

(4 citation statements)

References 43 publications

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“…1,2 The most frequently reported adverse effects related to TRZ treatment are orthostatic hypotension, syncope, headaches, dizziness, balance disorders, somnolence, and dry mouth. 3 Although it is widely used due to its lower anticholinergic properties and cardiac adverse effects compared to tricyclic antidepressants, and cardiac adverse effects than tricyclic antidepressants, the results of limited clinical studies investigating cardiovascular adverse effects of TRZ are conflicting. 4 It has been noted that TRZ may cause possible cardiovascular adverse effects because of the increased number of cardiotoxicity reports associated with TRZ treatment over the past years.…”

Section: Introductionmentioning

confidence: 99%

Assessment of trazodone-induced cardiotoxicity after repeated doses in rats

et al. 2018

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Trazodone (TRZ) is an antidepressant drug commonly used in the treatment of depression, anxiety, and insomnia. Although some studies demonstrated the adverse effects of TRZ related to cardiovascular system, the conflicting results were observed in these studies. Therefore, we aimed to investigate the cardiac adverse effects of TRZ in rats at repeated doses in our study. In accordance with this purpose, TRZ was administered orally to rats at 5, 10, and 20 mg/kg doses for 28 days. Electrocardiogram records, serum aspartate aminotransferase (AST), lactate dehydrogenase, creatine kinase-myoglobin band, cardiac troponin-T (cTn-T) levels, DNA damage in cardiomyocytes, and histologic view of heart tissues were evaluated. In addition, glutathione (GSH) and malondialdehyde (MDA) levels were measured to determine the oxidative status of cardiac tissue after TRZ administration. Heart rate was decreased, PR interval was prolonged, and QRS and T amplitudes were decreased in 20 mg/kg TRZ-administered group compared to the control group. Serum AST and cTn-T levels were significantly increased in 10 and 20 mg/kg TRZ-administered rats with respect to control rats. DNA damage was significantly increased in these groups. Additionally, degenerative histopathologic findings were observed in TRZ-administered groups. Although there was no difference in MDA levels between groups, GSH levels were significantly decreased in 10 and 20 mg/kg TRZ-administered groups compared to the control group. Our results have shown that TRZ induced cardiotoxicity in rats dose-dependently. It is assumed that oxidative stress related to GSH depletion may be accompanied by these adverse effects.

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Section: Introductionmentioning

confidence: 99%

Assessment of trazodone-induced cardiotoxicity after repeated doses in rats

et al. 2018

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“…and neural hormone (thyroid, growth, hypothalamus-pituitaryadrenal cortex axis) abnormalities can all increase the risk of the onset of depression (Saveanu and Nemeroff, 2012;Dell'osso et al, 2016). Antidepressants currently treating depression, tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), and selective serotonin reuptake inhibitors (SSRI), which control existing monoamine levels, have side effects such as constipation, decreased vision, high blood pressure, cognitive impairment, and anticholinergic effects (Donoghue and Tylee, 1996;Feighner, 1999;Tarleton et al, 2016). Furthermore, while such early antidepressants are fast-acting and inexpensive, clinical studies have associated their use with low recovery rates, only 22-40% of patients with depression (Anthes, 2014).…”

Section: Introductionmentioning

confidence: 99%

Antidepressant and Anxiolytic-Like Effects of the Stem Bark Extract of Fraxinus rhynchophylla Hance and Its Components in a Mouse Model of Depressive-Like Disorder Induced by Reserpine Administration

Kim¹,

Park

Seo

et al. 2021

Front. Behav. Neurosci.

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There is an urgent need to find antidepressants that can be administered for long periods without inducing severe side effects to replace conventional antidepressants that control monoamine levels, such as tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), and selective serotonin reuptake inhibitors (SSRI). We sought to determine the antidepressant effects of Fraxinus rhynchophylla Hance (F. rhynchophylla Hance, FX) and its components on a reserpine-induced mouse model. One hour after oral administration of FX (30, 50, and 100 mg/kg), esculin (50 mg/kg), esculetin (50 mg/kg), fraxin (50 mg/kg), and fluoxetine (20 mg/kg), reserpine was delivered intraperitoneally to mice. Behavioral experiments were conducted to measure anxiety and depressive-like behaviors after 10 days of administration. FX and its components increased the number of entries into the center of an open field as well as distance traveled within it and decreased immobility duration in the forced swim and tail suspension tests. Reserpine-induced increases in plasma corticosterone concentrations were attenuated by the administration of FX and its components, which were also found to decrease the reserpine-induced enhancement of mRNA levels of interleukin (IL)-12 p40, IL-6, and tumor necrosis factor (TNF)-α, pro-inflammatory cytokines. Finally, the diminished expressions of hippocampal phosphorylated cAMP response element-binding protein (pCREB) and brain-derived neurotrophic factor (BDNF) by reserpine were increased by FX and its components. Our results suggest that FX and its components regulate anxiety and depressive-like behaviors through stress hormones, immune regulation, and the activation of neuroprotective mechanisms, further supporting the potential of FX and its components as antidepressants.

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“…Considering the side effects of antidepressant drugs (Tarleton et al, 2016), this is essential to study how to prevent and treat depression in other ways. In the present study, we aimed to study the antidepressant effects of kefir, a probiotic supplement, and L. rhamnosus GG, compare their effects, and investigate their potential use in depression treatment.…”

Section: Introductionmentioning

confidence: 99%

A probiotic supplement, Lactobacillus rhamnosus GG, and kefir separately can improve mood and exhibit potential anti-depressant-like activities in mice

soltanmoradi¹,

Maniati²,

Davoodabadi³

et al. 2021

AAlim

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Depression is a common psychiatric disorder that can be continuous or recurrent. It has been previously reported that intestine probiotics play an essential role in the bidirectional communication of the intestine and brain. This study aims to investigate the antidepressant effects of kefir, a probiotic supplement, and Lactobacillus rhamnosus GG and their potentials in depression-like behaviour treatment in two-week and four-week treatments. In the present study, BALB/c mice were used for this purpose. The saline- and fluoxetine-treated groups were designed as negative and positive control groups, respectively. The forced swimming and tail suspension tests have been performed to assess the level of depression-like activity. We have observed that two-week treatment reduces the duration of depression-like activities, and four-week treatment enhances the antidepressant properties. Overall, our results suggest that kefir, L. rhamnosus GG, and the investigated probiotic supplement have antidepressant-like properties.

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Primer for nutritionists: Managing the side effects of antidepressants

Cited by 10 publications

References 43 publications

Assessment of trazodone-induced cardiotoxicity after repeated doses in rats

Assessment of trazodone-induced cardiotoxicity after repeated doses in rats

Antidepressant and Anxiolytic-Like Effects of the Stem Bark Extract of Fraxinus rhynchophylla Hance and Its Components in a Mouse Model of Depressive-Like Disorder Induced by Reserpine Administration

A probiotic supplement, Lactobacillus rhamnosus GG, and kefir separately can improve mood and exhibit potential anti-depressant-like activities in mice

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