Primary Tumors of the Optic Nerve (A Phenomenon of Recklinghausen's Disease)

Arachnoid hyperplasia in optic nerve glioma: confusion with orbital meningioma.

“…Proliferation of conti-guous tissue elements has been noted in the connective tissue trabeculae of the optic nerve (Kiel, 1923), in the capillaries within the optic nerve glioma, and the supporting tissues of the arachnoid. Davis (1940) emphasised the development of arachnoid hyperplasia, which appeared to follow extension of the glioma beyond the pial sheath of the optic nerve. Arachnoid hyperplasia is seen as an orderly arrangement of meningothelial or cap cells with or without psammoma bodies.…”

Arachnoid hyperplasia in optic nerve glioma: confusion with orbital meningioma.

“…Proliferation of conti-guous tissue elements has been noted in the connective tissue trabeculae of the optic nerve (Kiel, 1923), in the capillaries within the optic nerve glioma, and the supporting tissues of the arachnoid. Davis (1940) emphasised the development of arachnoid hyperplasia, which appeared to follow extension of the glioma beyond the pial sheath of the optic nerve. Arachnoid hyperplasia is seen as an orderly arrangement of meningothelial or cap cells with or without psammoma bodies.…”

Optic nerve glioma and phaeochromocytoma associated with von Recklinghausen's disease: A case report.

“…10 to 40% of patients with optic nerve glioma show evidence of von Recklinghausen's disease (Davis, 1940;Marshall, 1954 inter al.). Conversely Crowe et al (1956) found 2 histologically proved optic nerve gliomas in a series of223 patients with von Recklinghausen's disease (09 %), but in addition there were several cases of blindness without surgery and histological confirmation.…”

Optic pathway gliomas

“…The patient was treated surgically, and the tumor was described as “seated in the substance of the optic nerve; the coat of the nerve being very much distended, and evidently forming the outer covering of the tumor.” It was not until 40 years later, that optic nerve tumors were recognized as separate from other tumors of the orbit 2, but by the early 1900s, such tumors were more clearly defined as non‐metastatic; locally aggressive; indolent; seen principally in children, particularly those with “fibromatosis;” and commonly extending intracranially 3. Ensuing surgical and pathological studies further characterized the neoplasm 4–10, and positively established its association with neurofibromatosis (NF‐1) 7–14.…”

“…Tumors of the optic pathways comprise 4%–6% of all childhood brain tumors, with OPG representing approximately 65% of optic pathway neoplasms 7,8,15–18. In 1994, a survey was compiled of all available published cases through 1992 17.…”

Arachnoid hyperplasia in optic nerve glioma: confusion with orbital meningioma.

“…Proliferation of conti-guous tissue elements has been noted in the connective tissue trabeculae of the optic nerve (Kiel, 1923), in the capillaries within the optic nerve glioma, and the supporting tissues of the arachnoid. Davis (1940) emphasised the development of arachnoid hyperplasia, which appeared to follow extension of the glioma beyond the pial sheath of the optic nerve. Arachnoid hyperplasia is seen as an orderly arrangement of meningothelial or cap cells with or without psammoma bodies.…”

Optic nerve glioma and phaeochromocytoma associated with von Recklinghausen's disease: A case report.

“…10 to 40% of patients with optic nerve glioma show evidence of von Recklinghausen's disease (Davis, 1940;Marshall, 1954 inter al.). Conversely Crowe et al (1956) found 2 histologically proved optic nerve gliomas in a series of223 patients with von Recklinghausen's disease (09 %), but in addition there were several cases of blindness without surgery and histological confirmation.…”

Optic pathway gliomas

“…The patient was treated surgically, and the tumor was described as “seated in the substance of the optic nerve; the coat of the nerve being very much distended, and evidently forming the outer covering of the tumor.” It was not until 40 years later, that optic nerve tumors were recognized as separate from other tumors of the orbit 2, but by the early 1900s, such tumors were more clearly defined as non‐metastatic; locally aggressive; indolent; seen principally in children, particularly those with “fibromatosis;” and commonly extending intracranially 3. Ensuing surgical and pathological studies further characterized the neoplasm 4–10, and positively established its association with neurofibromatosis (NF‐1) 7–14.…”

“…Tumors of the optic pathways comprise 4%–6% of all childhood brain tumors, with OPG representing approximately 65% of optic pathway neoplasms 7,8,15–18. In 1994, a survey was compiled of all available published cases through 1992 17.…”

Arachnoid hyperplasia in optic nerve glioma: confusion with orbital meningioma.

“…Proliferation of conti-guous tissue elements has been noted in the connective tissue trabeculae of the optic nerve (Kiel, 1923), in the capillaries within the optic nerve glioma, and the supporting tissues of the arachnoid. Davis (1940) emphasised the development of arachnoid hyperplasia, which appeared to follow extension of the glioma beyond the pial sheath of the optic nerve. Arachnoid hyperplasia is seen as an orderly arrangement of meningothelial or cap cells with or without psammoma bodies.…”

Optic nerve glioma and phaeochromocytoma associated with von Recklinghausen's disease: A case report.

“…10 to 40% of patients with optic nerve glioma show evidence of von Recklinghausen's disease (Davis, 1940;Marshall, 1954 inter al.). Conversely Crowe et al (1956) found 2 histologically proved optic nerve gliomas in a series of223 patients with von Recklinghausen's disease (09 %), but in addition there were several cases of blindness without surgery and histological confirmation.…”

Optic pathway gliomas

“…The patient was treated surgically, and the tumor was described as “seated in the substance of the optic nerve; the coat of the nerve being very much distended, and evidently forming the outer covering of the tumor.” It was not until 40 years later, that optic nerve tumors were recognized as separate from other tumors of the orbit 2, but by the early 1900s, such tumors were more clearly defined as non‐metastatic; locally aggressive; indolent; seen principally in children, particularly those with “fibromatosis;” and commonly extending intracranially 3. Ensuing surgical and pathological studies further characterized the neoplasm 4–10, and positively established its association with neurofibromatosis (NF‐1) 7–14.…”

“…Tumors of the optic pathways comprise 4%–6% of all childhood brain tumors, with OPG representing approximately 65% of optic pathway neoplasms 7,8,15–18. In 1994, a survey was compiled of all available published cases through 1992 17.…”