Primary tuberculous cerebellar abscess: case report

Saini, Arushi Gahlot; Dogra, Sandeep; Kumar, Raj; Nada, Ritambhra; Singh, Mukhtar

doi:10.1179/1465328111y.0000000037

Cited by 3 publications

(1 citation statement)

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“…Abscesses manifest as encapsulated collections of pus that contain tubercular bacilli in absence of typical TB granuloma features including epithelioid and giant cells and mononuclear cell infiltrates . These abscesses have been reported in the cerebrum and posterior fossa, occur infrequently in the brain stem, and may be singular or multiple …”

Section: Macroscopic Manifestations Of the Disease In Relation To Thementioning

confidence: 99%

The pathogenesis of tuberculous meningitis

Davis

Rohlwink

Proust

et al. 2019

Journal of Leukocyte Biology

132

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Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM), which represents a medical emergency associated with high rates of mortality and disability. Via various mechanisms the Mycobacterium tuberculosis (M.tb) bacillus disseminates from the primary site of infection and overcomes protective barriers to enter the CNS. There it induces an inflammatory response involving both the peripheral and resident immune cells, which initiates a cascade of pathologic mechanisms that may either contain the disease or result in significant brain injury. Here we review the steps from primary infection to cerebral disease, factors that contribute to the virulence of the organism and the vulnerability of the host and discuss the immune response and the clinical manifestations arising. Priorities for future research directions are suggested. K E Y W O R D S mycobacterial, endothelial cells, granulocytes, microglia cells, monocytes/macrophages, myeloid cells, neutrophils, T Lymphocytes, Th17 cells at the site of infection activates macrophages and DCs to produce cytokines and antimicrobial factors that contribute to containment of the TB bacillus. 2 This inflammatory process results in the formation of a granuloma, which encapsulates the infected cells and retards the replication of TB bacilli and can lead to latent infection. However, in

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Section: Macroscopic Manifestations Of the Disease In Relation To Thementioning

confidence: 99%