Primary synovial sarcomas in the paediatric and young adult population: A pictorial review

Hickson, Melissa; McHugh, Kieran; McCarville, Beth

doi:10.1016/j.ejrad.2020.109376

Cited by 6 publications

(5 citation statements)

References 32 publications

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“…Color Doppler shows vascularity within the solid component [ 7 ]. Radiography can appear normal in small synovial sarcomas [ 8 ], so cross-sectional imaging is more helpful.…”

Section: Discussionmentioning

confidence: 99%

Chest Wall Synovial Sarcoma: A Unique Encounter at the Breast Base

Idrees,

Malik,

Malik

et al. 2024

Cureus

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Synovial sarcomas most commonly arise in the para-articular locations of the extremities, such as the upper limbs, thigh, knee, ankle, and foot. Thoracic synovial sarcomas are a rare entity that can arise in the chest wall, pleura, lung, heart, or mediastinum. We present a case of a 23-year-old female with a complaint of swelling of the left breast. Examination demonstrated an enlarged left breast and a hard-fixed swelling without overlying skin changes or nipple retraction. Ultrasound showed a well-defined, solid-appearing lesion deep in the left breast parenchyma, which was adherent to the underlying left chest wall musculature and seemed to be displacing the breast parenchyma anteriorly. Contrast-enhanced computed tomography (CECT) and magnetic resonance imaging (MRI) confirmed the lesion centered at the left pectoralis major and minor muscles, confirming the chest wall's origin. Histopathology findings favored monophasic synovial sarcoma.

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“…Color Doppler shows vascularity within the solid component [ 7 ]. Radiography can appear normal in small synovial sarcomas [ 8 ], so cross-sectional imaging is more helpful.…”

Section: Discussionmentioning

confidence: 99%

Chest Wall Synovial Sarcoma: A Unique Encounter at the Breast Base

Idrees,

Malik,

Malik

et al. 2024

Cureus

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show abstract

Section: Discussionmentioning

confidence: 99%

“…SS occurring in the head and neck usually lacks unique clinical symptoms and specific imaging modalities; therefore, it is difficult to distinguish between benign and malignant tumours based on imaging examinations and clinical findings, which means that pathological examination is extremely important and necessary. 9 Histopathologically, SS is usually divided into two subtypes, namely biphasic and monophasic patterns. A biphasic morphology (mesenchymal and epithelial components) is observed in 25% of SSs.…”

Section: Discussionmentioning

confidence: 99%

A case of a 22-year-old man with primary synovial sarcoma of the parapharyngeal space with an AR somatic mutation: A case report and review of the literature

Jiang¹,

Ma²,

Nie³

et al. 2022

SAGE Open Medical Case Reports

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This case report describes a 22-year-old man with a pharyngeal foreign body sensation arising from the left side of the postpharyngeal wall. Histological examination showed a biphasic pattern of epithelioid and spindle cells including glandular differentiation. The tumour was positive for vimentin and SS18-SSX, and the spindle cells were positive for bcl-2; in contrast, the epithelioid tumour cells were positive for pan-cytokeratin, epithelial membrane antigen and CD99. There was no INI-loss in tumour cells. Then, the presence of the SYT-SSX gene fusion was demonstrated by fluorescence in situ hybridization. In addition, androgen receptor gene somatic mutations were detected by next-generation sequencing. However, 6 months postoperatively, the patient had neither developed a recurrence nor received adjuvant radiotherapy and chemotherapy. Accurate diagnosis depends on morphological and immunohistochemical examination and a proper molecular analysis, and novel technologies can detect a wide variety of genetic alterations. Although androgen receptor somatic mutations cannot provide addition treatment at present, surgical resection with a clean margin and follow-up is an appropriate approach.

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“…Approximately 70-80% of neoplasms in the parapharyngeal space reported in the literature are benign, which means that sarcoma in this location is rare [4]. Synovial sarcoma occurring in the head and neck usually lacks unique clinical symptoms and speci c imaging modalities; therefore, it is di cult to distinguish between benign and malignant tumours based on imaging examinations and clinical ndings [5], which means that pathological examination is extremely important and necessary.…”

Section: Discussionmentioning

confidence: 99%

A Case of a 22-year-Old Man with Primary Synovial Sarcoma of the Parapharyngeal Space with an AR Somatic Mutation: A Clinicopathologic Study and Literature Review

Jiang

Ma²,

Nie³

et al. 2021

Preprint

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Background: Synovial sarcoma (SS) is a rare and aggressive entity that occurs predominantly in young adults. SS can arise in almost any part of the body, especially in the extremities. The incidence of SS in the parapharyngeal space is, however, quite low. Case presentation: Herein, we describe a case of a biphasic SS in the parapharyngeal space. A 22-year-old man presented with a pharyngeal foreign body sensation and underwent excision of the mass with a clear margin. Pathological examinations of the tumour specimen revealed a 1.7×1.5×1.2 cm spherical, well-circumscribed mass arising from the left side of the postpharyngeal wall. Histological examination showed a biphasic pattern of epithelioid and spindle cells, including glandular differentiation. Immunophenotype: Immunohistochemically, the tumour cells were positive for vimentin, and the spindle cells were positive for bcl-2; in contrast, the epithelioid tumour cells were positive for cytokeratin (CK) and epithelial membrane antigen (EMA) and weakly positive for CD99. The tumour cells were scattered positive for SMA. Thyroid transcription factor 1 (TTF-1), thyroglobulin (TG), p63, WT-1 and S100 were negative, and the proliferative index (Ki-67) was found in approximately 70% of the tumour cells. Then, the presence of the SYT-SSX gene fusion was demonstrated by fluorescence in situ hybridization (FISH). In addition, androgen receptor (AR) gene somatic mutations were detected by next-generation sequencing (NGS). Two months postoperatively, the patient had neither developed a recurrence nor received adjuvant radiotherapy and chemotherapy. Conclusions: Accurate diagnosis depends on morphological and immunohistochemical examination and a proper molecular analysis, and novel technologies can detect a wide variety of genetic alterations. The prognosis is relatively good in patients who undergo surgical resection with a clean margin.

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Primary synovial sarcomas in the paediatric and young adult population: A pictorial review

Cited by 6 publications

References 32 publications

Chest Wall Synovial Sarcoma: A Unique Encounter at the Breast Base

Chest Wall Synovial Sarcoma: A Unique Encounter at the Breast Base

A case of a 22-year-old man with primary synovial sarcoma of the parapharyngeal space with an AR somatic mutation: A case report and review of the literature

A Case of a 22-year-Old Man with Primary Synovial Sarcoma of the Parapharyngeal Space with an AR Somatic Mutation: A Clinicopathologic Study and Literature Review

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Primary synovial sarcomas in the paediatric and young adult population: A pictorial review

Cited by 6 publications

References 32 publications

Chest Wall Synovial Sarcoma: A Unique Encounter at the Breast Base

Chest Wall Synovial Sarcoma: A Unique Encounter at the Breast Base

A case of a 22-year-old man with primary synovial sarcoma of the parapharyngeal space with an AR somatic mutation: A case report and review of the literature

A Case of a 22-year-Old Man with Primary Synovial Sarcoma of the Parapharyngeal Space with an AR&nbsp;Somatic Mutation: A Clinicopathologic Study and Literature Review

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A Case of a 22-year-Old Man with Primary Synovial Sarcoma of the Parapharyngeal Space with an AR Somatic Mutation: A Clinicopathologic Study and Literature Review