Primary Synovial Sarcoma of Lung

Abstract

Synovial sarcoma (SS) is a highly malignant tumor that accounts for 10% of all soft-tissue sarcomas. Primary SS arising from the lung is extremely rare, and the prognosis is poor. We report a case of pulmonary SS presenting with a mass lesion invading the right upper and middle lobes, extending to the mediastinum and the chest wall. After tru-cut biopsy, surgical resection was performed. The final diagnosis was SS (biphasic type) based on histological and immunohistochemical findings. There are no guidelines for optimal treatment due to the rarity of these tumors. Current treatment includes surgery and adjuvant chemotherapy and/or radiotherapy.

Outcomes of surgically managed primary lung sarcomas: a National Cancer Database analysis

“…Our findings confirm superior OS for surgical patients in whom an R0 resection was achieved in both unadjusted and adjusted models. This data is consistent with previous reports on the association between OS and complete surgical resection (1,2,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). In our study population, R0 resection was achievable in 73.2% of cases.…”

“…The diagnosis of PLS is established only after more common pathology, such as pulmonary sarcomatoid carcinoma and metastatic extrapulmonary sarcoma, have been excluded. Owing to its rarity, the current characterization of these tumors has been limited to data from small case reports and retrospective tumor registries (1,2,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Several clinical series suggest that PLS is associated with more aggressive behavior and inferior survival compared to other primary lung malignancies, with an expected 3-year survival of 17% to 50% following surgery (1,8,16,17).…”

Sarcoma sinovial monofásico primario pulmonar

“…La recidiva local puede ocurrir como infiltración al mediastino, pericardio o pared torácica. [6][7][8] El pronóstico de la enfermedad es pobre, aunque algunos estudios muestran que el rango de sobrevivencia a los cinco años se encuentra entre 36 % y 70 %. 5,9 Se presenta un caso de SS primario del pulmón.…”

“…Aunque las características citomorfológicas e inmunohistoquímicas son suficientes para tal fin, la correlación clínica es también esencial para el diagnóstico. 6…”