Primary restless legs syndrome in patients with type 2 diabetes mellitus : efficacy of magnesium &amp; co enzyme q10 therapy

Metta, Vinod; Sampath, Naganandini; Vm, Reznichenko; Iska, Anilkumar R

doi:10.1016/j.jns.2015.08.952

Cited by 3 publications

(4 citation statements)

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“…Nevertheless, both intervention groups outperformed the control group. This result is consistent with other research on this subject, such as the study conducted by Sinniah and Metta [ 10 , 11 ].…”

Section: Discussionsupporting

confidence: 93%

“…In his study, Sinniah described a patient with RLS/WED who recovered entirely after taking magnesium sulfate intravenously [ 10 ]. A study by Yıldırım & Apaydın, as well as a study by Meta et al, both show that magnesium therapy can lower the intensity of symptoms of this illness and improve the quality of sleep of patients, suggesting that magnesium may be considered an appropriate replacement for the treatment of patients with RLS/WED [ 8 , 11 ]. However, there is some evidence that magnesium is useless in treating this condition [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial

Jadidi

Ashtiani

Hezaveh

et al. 2022

BMC Complement Med Ther

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Background and objective Restless legs syndrome/Willis-Ekbom Disease (RLS/WED) is one of the most prevalent sleep disorders. There are contradicting data about the effectiveness of magnesium and vitamin B6 in alleviating the symptoms of this condition. Therefore, this study aimed to assess the efficacy of magnesium and vitamin B6 in alleviating the symptoms of RLS/WED. Methods A single-blind study was conducted on individuals with this illness for at least three months. Randomly, 75 patients were assigned into three groups: magnesium, vitamin B6, and placebo. The experimental group received daily doses of 40 mg vitamin B6 or 250 mg magnesium oxide. While others in the control group merely received a placebo. Patients’ disease severity and sleep quality were evaluated three times using standard questionnaires (at the beginning of the study, one and two months after therapy). Utilizing SPSS22 software and the ANOVA, t-test, and repeated measure tests, statistical analysis was conducted. Results The mean and standard deviation of sleep quality and disease severity at the beginning of the trial and throughout the first month following the intervention did not differ statistically between the three groups. In the second month following the intervention, the mean and standard deviation of sleep quality and disease severity were significantly different (P = 0.001). Conclusion Taking magnesium and vitamin B6 supplements can reduce the severity of symptoms of RLS/WED patients and improve their sleep quality.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial

Jadidi

Ashtiani

Hezaveh

et al. 2022

BMC Complement Med Ther

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“…A study reported that magnesium deficiency could be a potential cause of increased RLS symptoms in patients undergoing dialysis [28]. Additionally, the potential therapeutic effects of magnesium and coenzyme Q replacement in patients with type 2 diabetes and RLS have been discussed [10].…”

Section: Discussionmentioning

confidence: 99%

“…Marshall et al conducted a comprehensive evaluation of cases involving magnesium and RLS, concluding that magnesium administration did not affect RLS symptoms [9]. However, contrasting findings have been reported in other studies [10,11].…”

Section: Introductionmentioning

confidence: 98%

A study of the correlation between magnesium and ferritin levels and the severity of the disease and sleep quality in restless legs syndrome

Üstün Özek

2024

J Surg Med

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Background/Aim: Restless legs syndrome (RLS) is a chronic neurological disease that impairs sleep quality, causes emotional stress and affects daily activities. While the association between disease severity and low iron and ferritin levels is known, the magnesium (Mg) results are contradictory. This study aimed to investigate the influence of low Mg and ferritin levels on the severity of the disease and sleep quality. Methods: A case-control study included 50 RLS patients aged 18–78 years and 50 healthy control patients. Mg and ferritin levels were measured, considering values below <1.8 mg/dL and 75 ng/mL as low. Both groups completed the International Restless Legs Syndrome Severity Rating Scale (IRLSSG) to assess the severity of RLS, as well as the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) to evaluate subjective sleep quality. Results: The mean age of RLS patients and the control group was 47.06 (13.35) years and 43.30 (15.43) years, respectively (P=0.196). The RLS patients had an IRLSSG score of 25.16 (6.85). The PSQI total scores, subscale scores, and ESS scores of RLS patients were significantly higher than those of the control group. However, no significant difference was observed in the IRLSSG score, PSQI, and ESS scores based on Mg and ferritin levels. Sleep latency was found to be shorter in individuals with Mg deficiency. Conclusion: Sleep disorders are prevalent among RLS patients. No correlation was found between Mg and ferritin levels and disease severity or sleep disorders. Furthermore, Mg deficiency did not appear to exacerbate the IRLSSG score or sleep disorder scores.

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Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: A systematic review

Marshall

Serinel

Killick

et al. 2019

Sleep Medicine Reviews

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Primary restless legs syndrome in patients with type 2 diabetes mellitus : efficacy of magnesium & co enzyme q10 therapy

Cited by 3 publications

References 0 publications

Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial

Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial

A study of the correlation between magnesium and ferritin levels and the severity of the disease and sleep quality in restless legs syndrome

Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: A systematic review

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