Primary renal lymphoma: A case report and literature review

Abstract

Abstract. Primary renal lymphoma (PRL) is a rare disease, with no more than 70 cases reported in the literature. The present study reports the case of a 70-year-old woman with PRL. The patient was asymptomatic, however, a mass on the right kidney was identified incidentally during routine physical examination. Computed tomography revealed a mass in the right kidney that was 3.6 cm in diameter. Subsequently, right nephrectomy was performed. The histological evaluation of the nephrectomy specimen showed diffuse large B-cell non-Hodgkin's lymphoma. The patient was treated with 6-8 cycles of a cyclophosphamide, epirubicin, vindesine and dexamethasone regimen. Follow-up examination performed after 2 months of treatment revealed no evidence of local recurrence. The present study also reviewed 49 cases of PRL that have been reported since 1989. It was found that a shorter survival time was experienced by patients with bilateral PRL (mean, 21 months) compared with unilateral PRL (mean, 68 months). A shorter survival time was also experienced by patients who were treated with chemotherapy only (mean, 15.8 months) compared with those who were treated with combination chemotherapy and surgery (mean, 49.4 months).

Primary renal lymphoma: A population‐based analysis using the SEER program (1973‐2015)

“…Most PRLs described in literature are histologically DLBCLs followed by extranodal MZL. 17,24,25 This is similar to our study in which DLBCL was the most common histologic subtype followed by extranodal MZL and FL. Other B-cell lymphomas including small lymphocytic lymphoma, chronic lymphocytic leukemia, and Burkitt lymphoma each comprised less than 5% of PRLs.…”

Primary Urinary Tract Lymphoma: Rare but Aggressive

“…Although the urinary tract does not have any organized lymphoid tissue, PUTL may originate from lymphoid cells attracted to the area from recurrent infections (4,5). This hypothesis is supported by regression of some lymphomas in other parenchymal organs after the use of antibiotics, particularly MALT-associated lymphomas (13).…”

“…A previous study failed to demonstrate an association between kidney lymphoma and Epstein-Barr virus infection (14). The most frequent symptoms in patients with kidney lymphoma are fever, weight loss, flank or abdominal pain, and hematuria (4), whereas the most frequent symptoms in bladder lymphomas are hematuria and recurrent urinary tract infections (5). Patients can have a flank mass on physical examination and may often present with acute kidney injury from renal parenchymal involvement or obstruction (15).…”

“…Primary urinary tract lymphoma (PUTL), first described in 1953 (3), is a very rare entity, with only a few case reports in the literature (4,5). Genitourinary tract NHLs represent 8.4% of extranodal lymphomas (6).…”

Synchronous Primary Renal Lymphoma and Renal Cell Carcinoma: Collision Tumors in the Same Kidney

“…1 PRL is defined as non-Hodgkin's lymphoma involving the kidney in the absence of systemic extranodal disease. To date, a total of 49 cases have been published regarding PRL.…”