Primary Pure Squamous Cell Carcinoma of the Duodenum: A Case Report

Abstract

Only two cases of squamous cell carcinoma of the duodenum have been reported in the literature. The author herein reports a case of squamous cell carcinoma of the duodenum. A 75-year-old man was admitted to our hospital because of nausea, vomiting, and weakness. An endoscopic examination revealed a duodenal tumor. The tumor was circumferential elevated one with duodenal obstruction, and located in the descending part near and distal to the ampulla of Vater. Imaging modalities also detected the duodenal tumor, but did not show tumors of other locations including the pancreas. The duodenal tumor was different from ampullary tumor and pancreatic tumor. Six biopsies were obtained from the duodenal tumor. All the six biopsies showed malignant cells arranged in a medullary pattern. The malignant cells showed hyperchromatic nuclei, and mitotic figures were scattered. Keratinization and intercellular bridges were recognized. The pathologic features were interpreted as a squamous cell carcinoma of the duodenum. The carcinoma was pure squamous cell carcinoma without differentiation into adenocarcinoma or endocrine carcinoma. Operation was not possible because of the patient’s age and weakness. The patient was treated by chemotherapy and radiation, but he showed a downhill course. Metastases emerged, and he died of systemic metastasis 17 months after the first presentation. Autopsy was not performed.

Squamous intraepithelial lesions and squamous cell carcinomas detected by endometrial sampling: Pap test correlation and outcome data

“…[1][2][3][4][5][6] By definition, primary SCC of the endometrium cannot have co-existing primary endometrial adenocarcinoma, connection with cervical squamous epithelium, or co-existing primary cervical SCC. [1][2][3][4][5][6] Primary endometrial SCC may arise in association with squamous metaplasia and dysplasia in the setting of pyometria 7,8 or ichthyosis uteri. [9][10][11] Rare cases of verrucous carcinoma of the endometrium have been also reported.…”

Primary Endometrial Squamous Cell Carcinoma In Situ: Report of a rare disease

“…18,19 A high Ki-67 in the differential diagnosis for these patients, despite its rarity. The exact pathogenesis is unclear and diagnosis is based on strict pathological criteria.…”

“…6,10 It is also essential to differentiate PESCC from endometrial SCC involvement based on the following strict pathological criteria recommended by Fluhmann: (1) no evidence of a coexisting endometrial adenocarcinoma or primary cervical SCC; (2) no connection between the endometrial tumour and squamous epithelium of the cervix; or Sujata Jetley, Zeeba S. Jairajpuri, Mohammad J. Hassan, Garima Madaan and Reena Jain Online Case Report | e561 labelling index has also been reported, demonstrating the aggressive and malignant nature of the lesion. 18 Lee et al found a positive immunoreactivity for the cytokeratin 7, p63 and p16INK4a proteins, but not for cytokeratin 20 or the oestrogen and progesterone receptors. 6 As a prognostic indicator of PESCC, the role of these receptors is still uncertain; however, lack of oestrogen cannot be completely ruled out as an aetiological factor since most patients diagnosed with PESCC are postmenopausal.…”

“…PESCC has been reported to show a poorer prognosis than endometrioid carcinomas. 18 Management for this condition usually consists of a surgical hysterectomy with adnexectomy and radiotherapy. 2 …”

The relationship between P53 and EGFR expression with development and progression of endometrial cancer

“…Also, [23] showed that expression for p53 can be seen in endometriod adenocarcinomas (~10%) cases.Our results positivity expression for p53 were higher significant in papillary serous than endometriod carcinomas. .However, [24] were explained that immunohistochemical positive for p53 [25] showed that in mucinous tumors p53 mutation was rarely.…”