Primary Pulmonary Histiocytosis in an Infant

Sole pulmonary involvement by Langerhans' cell histiocytosis in a child

“…There is no clear consensus about the natural history of isolated lung involvement in LCH in children, since it is a very uncommon condition [1,10,16]. McDoWELL et al [1] described one type with an initial stage consisting of respiratory symptoms, followed by failure to thrive; the chest radiograph is not suggestive of the disease at that stage.…”

“…After some time, symptoms improve but the radiological picture remains the same, or becomes even worse. Another type has been described (8,10,16], in which there are no prominent clinical signs before the diagnosis is made as a casual finding during routine examination. At this time, a honeycomb lung appearance is often found in chest X-rays because of delayed diagnosis.…”

“…Nevertheless, it is very unusual to find LCH limited to the lungs in children [8][9][10]. Only 12 cases were reported in the literature until 1987 [1].…”

Pulmonary eosinophilic gramuloma in a child.

“…The other was a female aged 9 months whose disease was also fatal at the age of 1 year, despite treatment. Necropsy established that the disease was confined to the lungs (Aftimos, Nassar, and Najjar, 1974). Most other patients in published reports with isolated lung disease are young adults, but a wide age range may be affected (Lewis, 1964).…”

Isolated Pulmonary Langerhans Cell Histiocytosis in a 17-year-old Male

“…3,4 When isolated pulmonary LCH occurs at younger ages (less than 14 y), there is no stated history of smoke exposure. [5][6][7][8][9][10][11][12][13] However, there was one case in which a toddler developed isolated pulmonary Langerhans whose parents were heavy smokers. 14 …”