Primary Osteosarcoma of the Breast

Fiori, Enrico; Burza, Antonio; Izzo, Luciano; Bolognese, Antonio; Savelli, Sara; Borrini, Francesco; Mingazzini, P; Cesare, Alessandro De; Leone, Giovanni; Borghese, M; Schillaci, Alberto; Cangemi, V.

doi:10.1111/j.1524-4741.2010.01008.x

Cited by 4 publications

(6 citation statements)

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“…The presence of palpable enlarged axillary lymph nodes on the side of the tumour has only been reported in two primary breast OS cases (4,12). Similar to the radiology examinations of the current patient, in mammography imaging, OS presents as a well-circumscribed, oval and firm calcified mass (6–8,11–15). In USG imaging, the tumour may be observed with blurred outlines, heterogeneous echogenicity and focal calcification (8,11,14,15).…”

Section: Discussionmentioning

confidence: 61%

“…The malignancy has also been observed in younger females (1,4,8,15,16). A report of male primary breast OS also exists (1).…”

Section: Discussionmentioning

confidence: 93%

“…Similar to the current patient, a physical examination revealed a palpable, firm, mobile mass that did not cause contraction of the nipple. Usually, it is without bloody leakage from the nipple and axillary lymph node enlargement (1,5–8,11,13–15). The presence of palpable enlarged axillary lymph nodes on the side of the tumour has only been reported in two primary breast OS cases (4,12).…”

Section: Discussionmentioning

confidence: 99%

“…Metastases in lymph nodes in breast OS cases are uncommon, as is OS localised in the bones (1,7,8,15,16,18). A lymphadenectomy in patients with OS is justified in situations where axillary lymphadenopathy is observed.…”

Section: Discussionmentioning

confidence: 99%

“…Applying this option is not standard treatment for the management of breast OS patients due to the limited number of clinical trials where polychemotherapy has been used in cases of this extremely rare tumour (1,4–6,11–15). In a situation where tumour-free surgical margins cannot be obtained, postoperative radiotherapy is sometimes advisable (4,5,8,19–20).…”

Section: Discussionmentioning

confidence: 99%

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Primary osteosarcoma of the breast: A case report

et al. 2014

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Osteosarcoma (OS) located in the breast is an extremely rare, malignant neoplasm. The current study presents the diagnostic process, treatment and follow-up of a 67-year-old female with OS of the breast. The diagnosis was made according to diagnostic imaging methods and microscopic examination with additional immunohistochemical staining. As a surgical treatment, tumourectomy with intraoperative histological examination and simple breast amputation was performed. No adjuvant chemotherapy was administered following surgery. Lung and bone metastases occurred without local recurrence 14 months following the surgery. In the present study, the details of the diagnostic examinations performed are evaluated and the consecutive phases of diagnostic and therapeutic proceedings are examined in comparison with the knowledge in the literature.

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Section: Discussionmentioning

confidence: 61%

“…The malignancy has also been observed in younger females (1,4,8,15,16). A report of male primary breast OS also exists (1).…”

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary osteosarcoma of the breast: A case report

et al. 2014

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A case of primary extraskeletal osteosarcoma of the breast

et al. 2018

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BackgroundPrimary sarcomas of the breast are rare and account for less than 1% of all primary breast malignancies. We experienced a case of extraskeletal osteosarcoma of the breast that had a unique clinical course and remarkable findings of mammography and magnetic resonance imaging (MRI). A review of the case reports published in the past few decades showed no reports of a case in which a calcified lesion was followed up three different times on mammography, making this a valuable case report.Case presentationA 52-year-old woman noticed a right breast mass and underwent a breast examination. Mammography showed a 1.5-cm coarse calcified lesion in the upper outer portion of the right breast. Because fine-needle aspiration (FNA) revealed no suspicion of malignancy, she was followed up. Sixteen months later, the tumor grew progressively to 4.5 cm in size with new calcifications that were fine and irregular in shape and density surrounding an enlarged, coarse calcified lesion. Contrast-enhanced magnetic resonance imaging (MRI) showed a high signal intensity in the periphery of the tumor. Extirpation of the tumor was indicated. The pathological findings were extraskeletal osteosarcoma. She underwent additional resection and latissimus dorsi flap reconstruction at the Department of Orthopedic Surgery.ConclusionThe present case suggests that mammography findings of a tumor with coarse calcifications that are not typical of benign lesions may be extraskeletal osteosarcoma. A diagnosis must be made as early as possible in order to improve the prognosis of this disease.

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