Primary Oat-Cell Carcinoma of Head and Neck

Gelot, Raghuvir; Rhee, Tae Ryang; Lapidot, Abraham

doi:10.1177/000348947508400218

Cited by 33 publications

(10 citation statements)

References 25 publications

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“…As of now, there are no well or moderately differentiated small cell neuroendocrine carcinomas, so SCNC is an acceptable synonym for the longer term listed above. SCNC of the larynx are uncommon but wellrecognized neoplasms (32,(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49). In a review by Gnepp (49), almost three fourths of patients died of widespread metastases.…”

Section: Poorly Differentiated Neuroendocrine Carcinoma Small Cell Typementioning

confidence: 99%

Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas

2002

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Tumors exhibiting neuroectodermal differentiation occur throughout the body, and the diverse tissues of the head and neck give rise to a wide assortment of these neoplasms. Neuroectodermal neoplasms may be divided into lesions showing primarily epithelial differentiation (Group I, neuroendocrine carcinomas) and a more diverse group (Group II) of nonepithelial neoplasms. This article reviews these neuroectodermal tumors of the head and neck with emphasis on the neuroendocrine carcinomas and their nomenclature. The author believes that with regard to Group I tumors, the older terminology of carcinoid, atypical carcinoid, and small cell carcinoma should be replaced by subclassifications of well-differentiated, moderately differentiated, and poorly differentiated neuroendocrine carcinoma. The latter category should be further subdivided into small cell and large cell variants. Neuroendocrine carcinomas, particularly the moderately differentiated subtype, are often underdiagnosed in the head and neck region. In the larynx, these tumors are the most common form of nonsquamous carcinoma. Poorly differentiated neuroendocrine carcinoma of small cell type is most common in the salivary glands but can occur elsewhere in the region. The large cell subtype of poorly differentiated neuroendocrine carcinoma has not been well documented in this region. However, the most likely candidate for this tumor category is the so-called sinonasal undifferentiated carcinoma. Group II tumors discussed include olfactory neuroblastoma, malignant melanoma, and Ewing's sarcoma. In addition, differential diagnostic problems related to Group I and II tumors are reviewed in detail. This article reviews and updates our understanding of neuroectodermal neoplasms arising in the head and neck. The focus is on tumors that exclusively involve this region or show a strong predilection to occur here.

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Section: Poorly Differentiated Neuroendocrine Carcinoma Small Cell Typementioning

confidence: 99%

Neuroectodermal Neoplasms of the Head and Neck with Emphasis on Neuroendocrine Carcinomas

2002

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“…The literature on NCL is fragmented over numerous case reports and series of small sample size, often with contradicting results, making it difficult to decide on an appropriate treatment strategy. Consequently, physicians facing these tumors often resort to treatment paradigms developed for better known neoplasms (eg, squamous cell carcinoma).…”

Section: Introductionmentioning

confidence: 99%

Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: A meta-analysis of 436 reported cases

et al. 2014

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“…In the larynx, at least, 11 oat cell carcino mas have been described [Benisch et al, 1975;Bitran et al, 1978;Eusebeel al., 1978;Eerlito, 1974;Gelot et al, 1975;Kyriakos et al, 1978;Mullins et al, 1979;Olofsson and Nostrand, 1972;Paladugu et al, 1982] with a prognosis as dismal as of the pulmonary tu mors. Neurosecretory granules have been demonstrated in a number of them.…”

Section: Discussionmentioning

confidence: 99%