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“…Even mouse lemur, which is placed at the basal node of primate taxonomy and roughly half the genetic distance between mice and humans, has been shown as a suitable model organism for drug development and genetics studies [ 33 ]. Investigation of gene evolution among primates can shed light on biochemical role, physiological and pathological functions of a certain gene, gene family, signaling network or metabolic pathway, and can offer insights in the discovery of prognostic biomarkers and therapeutic targets, which have been demonstrated in numerous articles (for example, [ 34 39 ]). In this article, we provide an example of how this can be utilized in the analysis of the MMP family enabled by the high-quality genomes across primates.…”
Section: Discussionmentioning
confidence: 99%
“…Even mouse lemur, which is placed at the basal node of primate taxonomy and roughly half the genetic distance between mice and humans, has been shown as a suitable model organism for drug development and genetics studies [ 33 ]. Investigation of gene evolution among primates can shed light on biochemical role, physiological and pathological functions of a certain gene, gene family, signaling network or metabolic pathway, and can offer insights in the discovery of prognostic biomarkers and therapeutic targets, which have been demonstrated in numerous articles (for example, [ 34 39 ]). In this article, we provide an example of how this can be utilized in the analysis of the MMP family enabled by the high-quality genomes across primates.…”
Section: Discussionmentioning
confidence: 99%