Primary neuroendocrine carcinoma of breast: A rare case report

Abstract

Primary neuroendocrine carcinoma (PNEC) of breast was an unknown pathologic entity till recently due its rare incidence and lack of definitive criteria for diagnosis. We present a case of PNEC of breast in a middle aged lady. A 34 years lady presented with a breast lump since 1 month, who underwent modified radical mastectomy with axillary clearance. Histopathological diagnoses were infiltrating ductal carcinoma-neuroendocrine (NE) type. Immunohistochemistry showed estrogen, progesterone positivity and NE markers positivity in more than 50% of tumor cells for chromogranin, synaptophysin, neuron specific enolase. On further investigation by whole body computed tomography and magnetic resonance imaging revealed no extra mammary primary tumor. Hence the diagnosis of PNEC of breast was confirmed. Patient received chemo and hormonal therapy and doing well after 6 months of follow up.

A population-based analysis of outcomes for small cell carcinoma of the breast by tumor stage and the use of radiation therapy

“…Since SCCB is rare and has not been extensively studied, treatment strategies are numerous and no recommended treatment protocol exists to guide clinicians. A combination of surgery, ranging from breast conserving to modified radical mastectomy, with adjuvant chemotherapy has been suggested in the treatment of localized and regional SCCB (Adams et al 2014 ; Adegbola et al 2005 ; Shin et al 2000 ; Ge et al 2012 ; Zekioglu et al 2003 ; Murthy et al 2013 ; Yildirim et al 2011 ; Lopez-Bonet et al 2008 ; Nicoletti et al 2010 ; Haji et al 2009 ; Navrozoglou et al 2011 ; Yamasaki et al 2000 ; Wei et al 2010 ). The use of radiation therapy remains controversial in the literature (Wei et al 2010 ; Yildirim et al 2011 ; Navrozoglou et al 2011 ).…”

Primary neuroendocrine carcinoma of the breast: A case report of liver and lymph node metastases after eight years from diagnosis

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Triple receptor-positive primary neuroendocrine carcinoma of breast in a young patient

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