Primary mucinous carcinoma in a 54-year-old man

Primary cutaneous mucinous carcinoma is a rare malignant tumor that originates from the deepest portion of the eccrine sweat duct. Common sites of involvement are the face and scalp. Biopsy shows dermal epithelial cell islands embedded in mucin pools separated by fibrous septae. It is difficult to differentiate this tumor histologically from metastatic adenocarcinoma. Recurrence after excision is common but metastases are rare. We report a primary cutaneous mucinous carcinoma with neuroendocrine differentiation on the right cheek of a 63-year-old man. (Ann Dermatol 22(4) 472∼477,

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“…The recurrence rate after excision with narrow margins is up to 30∼40%, especially for lesions located on the eyelid 23,24 .…”

Section: Discussionmentioning

confidence: 99%

A Case of Primary Cutaneous Mucinous Carcinoma with Neuroendocrine Differentiation

et al. 2010

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“…6,7 Clinical characteristics are variable and nonspecific, so a broad differential diagnosis including epidermoid cyst, sebaceous carcinoma, cystic basal cell carcinoma, squamous cell carcinoma, neuroma, lacrimal sac tumor, pilomatricoma, pyogenic granuloma, and vascular tumors must be considered. 1,6,7,8 Histologically, PCMC disclosed a well-circumscribed, multilocular, myxomatous tumor divided by thin fibrous septa in the dermis. 9 It is characterized by the presence of large amounts of pale-staining mucin surrounding nests of epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

“…1 It mainly affects elderly people (mean age: 65.2 years, range: 31-89) 2 of female sex (male: female ratio of 1:1.8) 2 with a predilection for the head and neck, particularly the eyelids. 2 Differential diagnosis includes mammary and gastrointestinal metastatic mucinous carcinoma and secondary cutaneous involvement by underlying neoplasms.…”

Section: Introductionmentioning

confidence: 99%

Mucinous Carcinoma of the Skin: Evaluation of Lymphatic Invasion With D2-40

Paradela¹,

Castiñeiras²,

Cuevas³

et al. 2008

The American Journal of Dermatopathology

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Primary cutaneous mucinous carcinoma is a rare adnexal sweat gland neoplasm that mainly affects elderly people. Differential diagnosis includes mammary and gastrointestinal metastatic mucinous carcinoma (MC) and secondary cutaneous involvement by underlying neoplasms. An 83-year-old woman presented with an 8-year history of slow-growing infiltrate plaque in her right hemithorax, with ulceration on supraclavicular area, right upper limb edema and palpable axillary lymphadenopathies. She underwent partial excision of the tumor and local radiotherapy. Imaging studies showed widespread cutaneous dissemination with enlargement of ipsilateral axillary lymph nodes but without evidence of underlying breast cancer. Histopathological examination showed large amounts of mucin in the dermis including small islands of epithelial cells. They stained positive for cytokeratin 7, carcinoembryonic antigen, epithelial membrane antigen, gross cystic disease fluid protein-15, and c-erbB-2. Lymphatic invasion was demonstrated by D2-40-immunostained sections. A diagnosis of primary cutaneous mucinous carcinoma was made. Our aim was to reevaluate the differential clinical, histopathological, and immunohistochemical criteria for distinguishing primary cutaneous mucinous carcinoma from skin metastases of visceral mucinous carcinoma, especially those arising in breast. We also propose D2-40 as a reliable marker to detect lymphatic invasion that indicates a strong aggressive trend with shorter recurrence-free and predicts nodal metastases.

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“…3,4 Several recent reports have successfully utilized Mohs micrographic surgery to treat cutaneous mucinous carcinomas. [12][13][14] Mohs micrographic surgery appears to be a suitable and effective means of treatment since these tumors usually form contiguous masses. Tumor cells are also easily visualized in frozen sections utilizing the toluidine blue stain, and the Mohs technique ensures complete removal of the tumor, which routine surgical excisions may not accomplish.…”

Section: Discussionmentioning

confidence: 99%