Primary mucinous (adenocystic) carcinoma of the skin

Grossman, J. R.

doi:10.1001/archderm.110.2.274

Cited by 9 publications

(5 citation statements)

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“…Differen tial diagnostic problems can arise with Borst-Jadassohn's epithelioma, an epidermotropic metastasis ofother adnexal, visceral (rectum and gall bladder) or mammary (Pag et's disease) adenocarcinomas, a superficial spreading amelanotic melanoma, a basocellular and a spinoccllular epithelioma. Other types of adnexal adenocarcinomas are dis tinguished from porocarcinomas mainly by the absence of the radial intraepidermal pro liferation and spread [4,7,17]. The still re cognizable glandular differentiation and the absence of keratinization in the porocarci nomas help to differentiate them from squa mous cell carcinomas [5,10], The clinical diagnoses are summarized in table II.…”

Section: Discussionmentioning

confidence: 99%

The Histology of Eccrine Poromas: A Study of 14 Cases

Pylyser¹,

Wolf‐Peeters²,

Mariën

1983

Dermatology

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A histological study of 14 eccrine poromas in 14 different patients was conducted and the results correlated with the clinical data. Histologically, an eccrine poroma is an easily recognizable epithelial skin tumor. Three morphological variants can be identified: a benign, a premalignant or dysplastic, and an invasive, malignant form. These tumors hardly have a typical clinical appearance. Symptoms such as bleeding, pain and itching are suggestive of a possible malignant transformation. There seems to be a predilection for localization on the limbs and the head. Most of the lesions occur in patients above the age of 60. It is noteworthy that these tumors, at least those of the face, occur on actinically damaged areas.

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Section: Discussionmentioning

confidence: 99%

The Histology of Eccrine Poromas: A Study of 14 Cases

Pylyser¹,

Wolf‐Peeters²,

Mariën

1983

Dermatology

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“…The individual tumor cells manifest hyperchromatic nuclei with nucleolation and a degree of cytologic atypia which varies from low grade to frankly anaplastic (Figures 13 and 14). [155][156][157][158][159][160][161][162][163] Cytoplasms are vacuolated and may show signet ring formation with peripheral displacement of the nucleus by a large intracytoplasmic vacuole. Pools of mucin dissect the stroma, creating rounded and irregularly shaped aggregates of PAS-positive, diastase-resistant material which decorates with Alcian blue or with Hale's colloidal iron.…”

Section: Histopathologymentioning

confidence: 99%

Malignant adnexal neoplasms

2006

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Malignant cutaneous adnexal neoplasms are one of the most challenging areas of dermatopathology. Tumors of the pilosebaceous apparatus can occur as single-lineage neoplasms or may manifest as complex proliferations with multilineal differentiation patterns including not only the germinative component of the hair bulb, the inner or outer root sheath epithelium and the sebaceous gland and duct, but also the sweat duct components that relate to the apocrine secretory apparatus which empties into the follicle near the follicular bulge. Eccrine and apocrine neoplasms present a bewildering array of morphologies, which often defy precise classification. The purpose of this review is to discuss in detail the malignant neoplasms of the cutaneous adnexae and their benign and prognostically indeterminate mimics. Modern Pathology (2006) 19, S93-S126. doi:10.1038/modpathol.3800511Keywords: eccrine carcinoma; sebaceous neoplasia Malignant tumors of the pilosebaceous apparatus, their mimics and precursors IntroductionTumors of the pilosebaceous unit can occur in isolation or in combination with complex proliferations showing multilineal differentiation patterns encompassing those of sweat ducts, epidermis and stroma with its varied components. In this review, we will focus upon the malignant adnexal proliferations, considering benign entities mainly insofar as they impact the diagnostic approach to adnexal carcinoma. We will first turn to the malignant sebaceous neoplasms, their precursors and their mimics. Sebaceous adenoma Clinical FeaturesThe sebaceous adenoma is a benign neoplasm that manifests clinically as a pale yellow nodular lesion, typically of the face, that expresses itself clinically after the age of 50. Tumors range in size from o1 to 45 cm. [1][2][3][4][5][6] These lesions are associated with the Muir-Torre syndrome, comprising the coexpression of cutaneous neoplasms, including those of sebaceous type with well-differentiated squamous epithelial neoplasms, and visceral malignancies, including carcinomas of the breast, ovary, gastrointestinal tract and larynx. [7][8][9][10][11][12][13][14] An occasional patient may manifest a malignant lymphoma of nodal or extranodal type. 10,12,14 Sebaceous neoplasms in the setting of Muir-Torre syndrome are often difficult to classify, showing overlap features between all of the prototypic forms of sebaceous neoplasm ranging from hyperplasia to carcinoma. 13 HistologyThe prototypic sebaceous adenoma manifests 1-2 layers of germinitive cells which mature to form central sebocytes, and have an architecture comprising a sharply circumscribed sebaceous lobule surrounded by a compressed pseudocapsule of dermal stroma ( Figure 1a). The overlying epidermis may be attenuated, but sometimes forms a collarette around the peripheral aspect of the neoplasm. Unlike sebaceous hyperplasia, occasional mitoses may be seen in the lobules of a sebaceous adenoma and in concert with this nucleoli may be somewhat prominent, but the pleomorphism, hyperchromasia and individual cell necrosis of the se...

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“…However, an obvious relationship between tum our C and A is present, and B and C may well represent various stages in the development o f MC. Discussion 15 cases of MC have so far been reported [1][2][3]. In 9 of 14 patients the primary histological diagnosis has been metastatic adenocarcinoma.…”

Section: Case Historymentioning

confidence: 99%

Mucinous (Adenocystic) Carcinoma of the Skin

Baandrup¹,

Søgaard²

1982

Dermatology

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A case of mucinous (adenocystic) carcinoma of the skin (MC) is presented. The differential diagnosis against metastasis from mucinous adenocarcinoma (mammary gland, gastrointestinal tract, ordinary sweat gland carcinoma) is emphasized. MC is characterised by its abundant content of non-sulphated mucopolysaccarides. MC is low-malignant with a tendency of local recurrence. Excision and subsequent yearly control is the treatment of choice.

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Primary mucinous (adenocystic) carcinoma of the skin

Cited by 9 publications

References 0 publications

The Histology of Eccrine Poromas: A Study of 14 Cases

The Histology of Eccrine Poromas: A Study of 14 Cases

Malignant adnexal neoplasms

Mucinous (Adenocystic) Carcinoma of the Skin

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