Primary mitral valve angiosarcoma: A multifaced ultra‐rare tumor

Akiash, Nehzat; Mombeini, Hoda; Gholizadeh, Behnam; Jazayeri, Sam; Azizidoost, Shirin

doi:10.1111/echo.15264

Cited by 2 publications

(2 citation statements)

References 8 publications

(11 reference statements)

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“…These include fatigue, weight loss, and a general sense of malaise. The lungs, liver, and lymphatic nodes are frequent sites of metastasis, substantially impacting the prognosis of the disease [ 6 , 7 ]. On echocardiography (both transthoracic and transesophageal), angiosarcomas typically present with an irregular mass, characterized by an immobile aspect, extending from the endocardium to the myocardium; pericardial effusion may be present as well [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

A Giant Primary Angiosarcoma Invading the Right Heart in a Young Male: An Emergency Surgery

Elmalki,

Berkane,

Moutaouekkil

2024

Cureus

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Primary cardiac angiosarcoma is very rare. In this report, we describe an interesting case of a 25-year-old male with a giant primary angiosarcoma invading the right heart. He was urgently admitted to the hospital for respiratory distress. Once the diagnosis was suspected by chest x-ray, echocardiography, and CT scan, and given the patient's hemodynamic and respiratory instability, an emergency open-heart surgery was necessary to prevent complications. Through a right atriotomy and a pulmonary infundibulotomy, the tumor was resected. Invaded by the tumoral process, the tricuspid valve was replaced with a biological prosthesis. The postoperative course was marked by severe right ventricular dysfunction with multiorgan failure. Histopathologic examination of the surgical specimen confirmed a primary cardiac angiosarcoma.

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Section: Discussionmentioning

confidence: 99%

A Giant Primary Angiosarcoma Invading the Right Heart in a Young Male: An Emergency Surgery

Elmalki,

Berkane,

Moutaouekkil

2024

Cureus

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“…These symptoms can include weight loss, anemia, and generalized malaise. Metastases commonly occur in the lungs, liver, lymph nodes, bones, and adrenals, and their presence can significantly worsen the prognosis of the disease [40][41][42].…”

Section: Clinical Presentationmentioning

confidence: 99%

Primary Cardiac Angiosarcoma: A Review

Kumari,

Bhandari,

Ishfaq

et al. 2023

Cureus

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Primary cardiac angiosarcoma is a rare and aggressive malignancy originating from the endothelial lining of cardiac blood vessels. This review covers various aspects of the disease, including its pathogenesis, clinical presentation, diagnosis, treatment, and prognosis. The primary characteristic of cardiac angiosarcoma is the rapid growth of abnormal blood vessels that invade the heart muscle, leading to the destruction of healthy tissue. Due to its infiltrative nature and early spread, diagnosing and treating cardiac angiosarcoma present significant challenges. Transesophageal echocardiography (TEE) plays a crucial role in diagnosing cardiac tumors such as angiosarcoma due to its high sensitivity. Additional imaging techniques such as computed tomography (CT) and cardiac magnetic resonance imaging (MRI) help assess tumor anatomy and identify metastases. Histopathological examination and immunohistochemistry are essential for confirming the diagnosis, as they reveal distinct histological features and specific endothelial markers associated with primary cardiac angiosarcoma. Targeted therapies directed at the angiogenic mechanisms and molecular abnormalities hold promise for improving treatment outcomes. Early detection of primary cardiac angiosarcoma remains challenging due to its rarity, and the prognosis is generally poor due to advanced disease at the time of diagnosis. The review emphasizes the importance of a multidisciplinary approach and collaboration among different specialties to optimize the diagnosis, treatment, and follow-up care of patients with primary cardiac angiosarcoma. The ultimate goal is to enhance diagnostic methods and therapeutic approaches by advancing knowledge and promoting further research into this aggressive malignancy.

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Primary mitral valve angiosarcoma: A multifaced ultra‐rare tumor

Cited by 2 publications

References 8 publications

A Giant Primary Angiosarcoma Invading the Right Heart in a Young Male: An Emergency Surgery

A Giant Primary Angiosarcoma Invading the Right Heart in a Young Male: An Emergency Surgery

Primary Cardiac Angiosarcoma: A Review

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