Primary malignant melanoma of the adrenal gland

Amérigo, J; Roig, José V.; Pulido, Francisco; Belda, Ricardo; Vázquez-Ramírez, Francisco José; González‐Cámpora, Ricardo

doi:10.1067/msy.2000.100467

Cited by 21 publications

(15 citation statements)

References 6 publications

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“…Primary melanoma of the adrenal, first reported in 1946, is extremely rare with between 20 and 30 cases reported in the world literature [117][118][119][120][121][122][123]. Diagnosis is difficult due to frequent adrenal metastases from melanoma.…”

Section: Primary Adrenal Melanomamentioning

confidence: 96%

Metabolic and anatomic characteristics of benign and malignant adrenal masses on positron emission tomography/computed tomography: a review of literature

et al. 2014

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PET/CT with (18)F-fluorodeoxyglucose (FDG) or using different radiocompounds has proven accuracy for detection of adrenal metastases in patients undergoing cancer staging. It can assist the diagnostic work-up in oncology patients by identifying distant metastases to the adrenal(s) and defining oligometastatic disease that may benefit from targeted intervention. In patients with incidentally discovered adrenal nodules, so-called adrenal "incidentaloma" FDG PET/CT is emerging as a useful test to distinguish benign from malignant etiology. Current published evidence suggests a role for FDG PET/CT in assessing the malignant potential of an adrenal lesion that has been 'indeterminately' categorized with unenhanced CT, adrenal protocol contrast-enhanced CT, or chemical-shift MRI. FDG PET/CT could be used to stratify patients with higher risk of malignancy for surgical intervention, while recommending surveillance for adrenal masses with low malignant potential. There are caveats for interpretation of the metabolic activity of an adrenal nodule on PET/CT that may lead to false-positive and false-negative interpretation. Adrenal lesions represent a wide spectrum of etiologies, and the typical appearances on PET/CT are still being described, therefore our goal was to summarize the current diagnostic strategies for evaluation of adrenal lesions and present metabolic and anatomic appearances of common and uncommon adrenal lesions. In spite of the emerging role of PET/CT to differentiate benign from malignant adrenal mass, especially in difficult cases, it should be emphasized that PET/CT is not needed for most patients and that many diagnostic problems can be resolved by CT and/or MR imaging.

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Section: Primary Adrenal Melanomamentioning

confidence: 96%

Metabolic and anatomic characteristics of benign and malignant adrenal masses on positron emission tomography/computed tomography: a review of literature

et al. 2014

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“…Masson-Fontana and hydrogen peroxide staining techniques have been used to demonstrate the melanotic nature of this pigment. 6 Radiologic features are not specific and calcification is not common. 7,8 Malignant melanoma originating outside the skin, squamous mucous membranes, eyes, and leptomeninges is rare.…”

Section: Discussionmentioning

confidence: 98%

“…Primary adrenal melanoma is a highly aggressive tumor that affects middle-aged adults and manifests itself as a painful flank mass, although distant lymph node metastasis can be seen on the initial examination. 6 The size of the lesions ranges from 8 to 17 cm in maximal diameter [1][2][3][4][5][6] and the tumors are com- posed of soft gray-brown to brown-black tissue with areas of hemorrhage and necrosis. 5,7 A histologic study reveals polygonal or spindle cells displaying an oval-toround nucleus with a prominent nucleolus and containing brown intracytoplasmic pigment.…”

Section: Discussionmentioning

confidence: 99%

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Primary Melanoma of the Adrenal Gland, a Continuous Dilemma: Report of a Case

2004

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The adrenal gland can frequently be the site of metastatic deposits, including malignant melanocytic tumors; however, primary melanoma of the adrenal gland is exceptional. We reviewed 18 cases reported in the English literature to date, and here add another case which occurred in a 78-year-old man. The patient underwent right suprarenalectomy and the pathology report showed a malignant melanoma of the adrenal gland. Immunohistochemical staining revealed a positive antibody-specific cytoplasmic reactivity to S-100 and HMB-45 proteins with a negative reaction for cytokeratin (AE1, AE3), synaptophysin, chromogranin and neuron-specific enolase. There are diagnostic criteria for accepting an adrenal melanoma as primary; however, an autopsy is the final step to confirm this infrequent pathology.

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“…2,9,10 Since these tumors adhere to the adjacent kidney, nephroadrenelectomy is the preferred surgical treatment modality. Liatsikos et al performed the first laparoscopic adrenalectomy in a patient with primary adrenal malignant melanoma.…”

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confidence: 99%