Primary infantile glaucoma in an Australian population

Abstract

Primary infantile glaucoma is a rare ocular condition in this population that presents at a mean age of 4.4 months. Surgical and visual outcomes are generally favourable.

Familial Transmission Risk of Infantile Glaucoma in Australia

“…In-depth phenotypic description of the majority of these recruited PIG probands has been presented previously. 2,19 The mean ± SD age at presentation in this cohort was 129 ± 83 days. Males were more commonly affected than females, at a ratio of 2:1.…”

“…Males were more commonly affected than females, at a ratio of 2:1. 2 The most common clinical features prompting referral were clouding (42.2%) and buphthalmos (38.6%). 2 One (1.8%) pedigree with PIG was identified as having POPT.…”

“…2 The most common clinical features prompting referral were clouding (42.2%) and buphthalmos (38.6%). 2 One (1.8%) pedigree with PIG was identified as having POPT. The proband in this pedigree (GTas406) was diagnosed with PIG 100 days after birth.…”

“…Infantile glaucoma was diagnosed following clinical appraisal for buphthalmos, loss of corneal transparency, Haab's striae, photophobia, raised intraocular pressure, and optic disc cupping. 2 Pedigrees were categorised according to the presence or absence of ASD. ASD was diagnosed by the presence of an abnormal iris appearance such as hypoplasia, polycoria, and corectopia.…”

“…1 The incidence of PIG, also referred to as congenital glaucoma, in Australia is approximately 1 per 30,000 births. 2 Secondary infantile glaucoma occurring during the same post-natal 93 94 A. W. HEWITT ET AL. period is characterized by structural, metabolic, inflammatory, or mitotic associations.…”