Primary granulomatous hypophysitis: a case report and literature review

Su, Shaobo; Zhang, Da-Jian; Yue, Shuyuan; Zhang, Jianning

doi:10.1507/endocrj.k10e-357

Cited by 26 publications

(36 citation statements)

References 43 publications

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“…Granulomatous hypophysitis (GH) is observed in less than 1% of patients with sellar lesions (1)(2)(3). GH may occur as a component of systemic granulomatous diseases, such as tuberculosis, sarcoidosis, Langerhans cell histiocytosis and syphilis, or as an isolated pituitary disease caused by a foreign body reaction or rupture of Rathke's cleft cyst.…”

Section: Introductionmentioning

confidence: 99%

“…GH may occur as a component of systemic granulomatous diseases, such as tuberculosis, sarcoidosis, Langerhans cell histiocytosis and syphilis, or as an isolated pituitary disease caused by a foreign body reaction or rupture of Rathke's cleft cyst. When all these conditions may be excluded, the term idiopathic GH (IGH) is used (1,2,4). IGH is a rare inflammatory disease of the pituitary gland of unknown etiology characterized by lymphoplasmacytic infiltration and the formation of granulomas comprised of epithelioid cells and multinucleated giant cells (2,4).…”

Section: Introductionmentioning

confidence: 99%

“…When all these conditions may be excluded, the term idiopathic GH (IGH) is used (1,2,4). IGH is a rare inflammatory disease of the pituitary gland of unknown etiology characterized by lymphoplasmacytic infiltration and the formation of granulomas comprised of epithelioid cells and multinucleated giant cells (2,4). GH is quite rare, with only case reports, no series, having been published to date (2).…”

Section: Introductionmentioning

confidence: 99%

“…IGH is a rare inflammatory disease of the pituitary gland of unknown etiology characterized by lymphoplasmacytic infiltration and the formation of granulomas comprised of epithelioid cells and multinucleated giant cells (2,4). GH is quite rare, with only case reports, no series, having been published to date (2). Among three large surgical series of more than 6,000 sellar tumors, only eight cases of IGH were identified (2).…”

Section: Introductionmentioning

confidence: 99%

“…GH is quite rare, with only case reports, no series, having been published to date (2). Among three large surgical series of more than 6,000 sellar tumors, only eight cases of IGH were identified (2). A considerable number of GH cases are initially misdiagnosed as adenoma due to the rarity of the lesions and nonspecific radiological features, with affected patients inappropriately receiving surgery (4).…”

Section: Introductionmentioning

confidence: 99%

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Idiopathic Granulomatous Hypophysitis: A Rare Cystic Lesion of the Pituitary

et al. 2015

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Idiopathic granulomatous hypophysitis (GH) is a rare inflammatory disease of the pituitary gland. A 48-year-old woman was admitted to the hospital with an irregular menstrual cycle. MRI showed pituitary cystic lesion with sellar enlargement. The patient underwent endoscopic endonasal transsphenoidal surgical excision. A histopathological assessment revealed non-necrotizing granulomatous lesions and a diagnosis of GH was made. The rarity of GH and cystic form of the disease make it difficult to confirm the diagnosis until surgery. We herein report this rare case and provide a discussion of the MRI findings and relevant literature of GH.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Idiopathic Granulomatous Hypophysitis: A Rare Cystic Lesion of the Pituitary

et al. 2015

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Granulomatous hypophysitis: rare disease with challenging diagnosis

el-Gamal

Mohamed

Fiad

et al. 2017

Clinical Case Reports

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Key Clinical MessageGranulomatous hypophysitis is rare pathology that mimics pituitary adenoma. Diagnosis is only confirmed by histopathology examination. Trans‐sphenoidal surgery is considered diagnostic when descent tissue specimen is obtained and therapeutic by decompressing optic pathway and the sella. Pathological findings always reveal granulomatous areas, multinucleated giant cells, plasma cells, and lymphocytes.

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