Primary follicular dendritic cell sarcoma of the pleura: A clinicopathological and immunohistochemical study of two cases

Alqaidy, Doaa; Moran, César A.

doi:10.1016/j.anndiagpath.2022.151944

Cited by 2 publications

(7 citation statements)

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“…Primary pleural follicular dendritic cell sarcoma has been reported; patients present with local/chest and systemic symptoms including fever and weight loss. 155 Grossly, follicular dendritic cell sarcoma appears solid and poorly marginated. Histologically, tumour cells are arranged in syncytial sheets, whorls, nodules, to a storiform pattern, and are spindle, ovoid, epithelioid to pleomorphic, with eosinophilic cytoplasm, elongated-to-oval nuclei, dispersed chromatin, small nucleoli, and smooth nuclear membrane.…”

Section: A L I G N a N T P E R I P H E R A L N E R V E S H E A T H T ...mentioning

confidence: 99%

“…Given its rarity and diverse histologic appearance, intrathoracic follicular dendritic cell sarcoma may be frequently misdiagnosed, although immunohistochemistry can aid the diagnosis and exclude mimics. 155,156 Tumour cells generally express multiple follicular dendritic cell markers, such as CD21 (Figure 4D), CD23, CD35 (Figure 4E), clusterin, D2-40, CXCL13, SSTR2, FDCSP, and SRGN. They may be variably positive for S-100 protein, CD68, EMA, and claudin-4.…”

Section: A L I G N a N T P E R I P H E R A L N E R V E S H E A T H T ...mentioning

confidence: 99%

“…They may be variably positive for S-100 protein, CD68, EMA, and claudin-4. [155][156][157][158][159][160] The background lymphocytes (Figure 4F) can harbour an immature T-cell phenotype. About 40%-50% of tumours harbour an increased number of TdT-positive lymphocytes indicative of indolent T-lymphoblastic proliferation, which is associated with paraneoplastic presentation.…”

Section: A L I G N a N T P E R I P H E R A L N E R V E S H E A T H T ...mentioning

confidence: 99%

“…Follicular dendritic cell sarcoma is more often extranodal, involving the retroperitoneum, gastrointestinal/aerodigestive tract, or mediastinum. Primary pleural follicular dendritic cell sarcoma has been reported; patients present with local/chest and systemic symptoms including fever and weight loss 155 …”

Section: Introductionmentioning

confidence: 99%

“…A subset of tumours display multinucleated to Reed Sternberg‐like cells, pseudovascular cystic degeneration, and/or prominent myxoid stroma. Given its rarity and diverse histologic appearance, intrathoracic follicular dendritic cell sarcoma may be frequently misdiagnosed, although immunohistochemistry can aid the diagnosis and exclude mimics 155,156 . Tumour cells generally express multiple follicular dendritic cell markers, such as CD21 (Figure 4D), CD23, CD35 (Figure 4E), clusterin, D2‐40, CXCL13, SSTR2, FDCSP, and SRGN.…”

Section: Introductionmentioning

confidence: 99%

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Mesenchymal tumours of the pleura: review and update

Rerkpichaisuth,

Hung

2023

Histopathology

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Primary mesenchymal tumours of the pleura are uncommon and can be diagnostically challenging due to their overlapping histopathologic and immunophenotypic features. Herein we discuss selected mesenchymal tumours of the pleura, including solitary fibrous tumour, calcifying fibrous tumour, desmoid fibromatosis, synovial sarcoma, schwannoma, malignant peripheral nerve sheath tumour, inflammatory myofibroblastic tumour, follicular dendritic cell sarcoma, epithelioid hemangioendothelioma, and desmoplastic small round cell tumour. We review their clinicopathologic characteristics, along with an update on the relevant immunohistochemical and molecular features.

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Section: A L I G N a N T P E R I P H E R A L N E R V E S H E A T H T ...mentioning

confidence: 99%

Section: A L I G N a N T P E R I P H E R A L N E R V E S H E A T H T ...mentioning

confidence: 99%

Section: A L I G N a N T P E R I P H E R A L N E R V E S H E A T H T ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mesenchymal tumours of the pleura: review and update

Rerkpichaisuth,

Hung

2023

Histopathology

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Case Report: Identification of a novel STAT3 mutation in EBV-positive inflammatory follicular dendritic cell sarcoma

Ramsey,

Sabatini,

Watson

et al. 2023

Front. Oncol.

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EBV-positive inflammatory follicular dendritic cell sarcoma (EBV+ IFDCS) is an uncommon disease primarily observed in Asia. It is characterized by the development of tumors believed to originate from follicular dendritic cells (FDC). The consistent association between this condition and clonal EBV infection suggests EBV’s involvement as an etiological factor. However, diagnosing EBV+ IFDCS can be challenging due to its morphological variability and diverse immunohistochemical staining patterns. The genetic characteristics of EBV+ IFDCS remain insufficiently understood. To address this knowledge gap, we present a case study of a 47-year-old male patient diagnosed with EBV+ IFDCS. We utilized a Next-generation sequencing (NGS) platform to investigate the genetic profile of the tumor cells. We identified a single pathogenic mutation (G618R) in the STAT3 gene. This finding provides valuable insights into the genetic alterations associated with EBV+ IFDCS and potentially contributes to our understanding of the disease’s pathogenesis.

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Primary follicular dendritic cell sarcoma of the pleura: A clinicopathological and immunohistochemical study of two cases

Cited by 2 publications

References 8 publications

Mesenchymal tumours of the pleura: review and update

Mesenchymal tumours of the pleura: review and update

Case Report: Identification of a novel STAT3 mutation in EBV-positive inflammatory follicular dendritic cell sarcoma

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