Primary Epstein–Barr virus-negative nasal-type natural killer/T cell lymphoma of the testis

Matsuda, Mitsuhiro; Iwanaga, Takayuki; Hashimoto, Shigeo; Uesugi, Tadao; Itagaki, Nobuo

doi:10.1016/j.leukres.2009.02.019

Cited by 16 publications

(12 citation statements)

References 6 publications

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“…Our patient had also had a painless testicular mass for the past three months. No pain or ascites was reported at the time of presentation [7,8]. Associated B symptoms (fever, night sweats, weight loss) usually present only in advanced stages, accounting for 25% to 41% of patients at diagnosis, and these were also not present in our patient [7-9].…”

Section: Discussionmentioning

confidence: 83%

“…Even for patients with stage I disease and good-risk International prognostic index (IPI), the outcome seems worse than that reported for diffuse large cell lymphoma (DLCL) at other sites [7-9]. There are reports of a high rate of extranodal recurrence and the frequent involvement of unusual sites.…”

Section: Discussionmentioning

confidence: 99%

“…EBV-associated T-cell/NK cell lymphomas most commonly involve the nasal cavities, and these are aggressive extranodal lymphomas. These are rarely encountered at sites other than the upper aero-digestive tract [6,7]. …”

Section: Discussionmentioning

confidence: 99%

“…However, recurrence of the mass developed after 8 months and ipisilateral inguinal lymph node involvement was also present. The patient is now under radiotherapy treatment [7,8]. …”

Section: Discussionmentioning

confidence: 99%

“…The duration of survival after relapse seems to be poor. Failures usually occur within 1 to 3 years after the initial therapy [7,9,10]. However, several late relapses of testicular lymphomas have been observed up to 14 years after diagnosis, especially in the central nervous system (CNS) and the contralateral testis, the latter raising the problem of distinguishing a new primary disease versus a late recurrence.…”

Section: Discussionmentioning

confidence: 99%

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Peripheral T-cell lymphoma presenting as testicular mass; a diagnostic challenge

Haroon

Ahmed

2013

World J Surg Onc

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BackgroundT-cell lymphomas involve the testis infrequently, which deserve special attention because of the poor prognosis and the need to make an appropriate diagnosis, which could lead to a better therapeutic strategy.Case presentationA 40-year-old man presented with right testicular swelling for past three months. The swelling was painless, hard and rubbery. Testicular ultrasound showed diffuse increase in size of the testicle, with alteration in its echogenicity. The patient underwent orchidectomy, and based on histopathological and immunohistochemical tests, a peripheral T-cell lymphoma, not otherwise specified was diagnosed.ConclusionTesticular peripheral T-cell lymphomas are rare and aggressive cancers, with clinical differentials of seminoma and non-neoplastic conditions.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…However, recurrence of the mass developed after 8 months and ipisilateral inguinal lymph node involvement was also present. The patient is now under radiotherapy treatment [7,8]. …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Peripheral T-cell lymphoma presenting as testicular mass; a diagnostic challenge

Haroon

Ahmed

2013

World J Surg Onc

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Comparative analysis of clinicopathologic characteristics and prognosis between nasal and nonnasal extranodal NK/T‐cell lymphoma

Shen,

Chen,

Sun

et al. 2023

Cancer Medicine

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BackgroundThe clinicopathologic characteristics and prognosis of nasal and nonnasal extranodal natural killer T‐cell lymphoma (ENKTL) are considered to be different. However, the underlying features responsible for these differences are not well clarified especially in the era of asparaginase therapy.MethodsIn total, 1007 newly diagnosed ENKTL patients from 11 medical centers were included in this study. Clinicopathologic characteristics and survival data were collected. The chi‐squared test and Kruskal–Wallis test were utilized for the comparison of different groups. Univariable and multivariable Cox proportional hazards models were used to screen prognostic factors.ResultsOverall, 869 (86.3%) patients were nasal forms. Compared to patients with nasal ENKTL, nonnasal patients were at more advanced stages and had poor performance status, bone marrow involvement, elevated serum lactate dehydrogenase (LDH), and CD56‐negative status (p < 0.05). The 5‐year overall survival (OS) for nasal and nonnasal patients were 65.6% and 45.0%, respectively. The OS of nasal forms patients were superior to nonnasal patients, especially in Eastern Cooperative Oncology Group performance status (ECOG PS) (≥2), advanced stage, KPI (HIR/HR), IPI (HIR/HR), PINK (HR), and high EBV DNA load groups. In patients treated with pegaspargase/L‐asparaginase‐based regimens, the OS of nasal patients was better than that of nonnasal patients. After adjusting the covariates of age, stage, ECOG PS score, LDH, B symptoms, and BM involvement, results showed that the nonnasal site was associated with poor survival of ENKTL.ConclusionsThe clinicopathologic characteristics and prognosis of nasal and nonnasal ENKTL patients are different. Nasal forms patients had superior OS than nonnasal patients, especially in the era of asparaginase.

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Epstein‐Barr virus‐negative extranodal “true” natural killer‐cell lymphoma harbouring a KDM6A mutation

Tsuyama

Asaka

Dobashi

et al. 2017

Hematological Oncology

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Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTL) is an extranodal aggressive T or NK-cell lymphoma that is characteristically associated with Epstein-Barr virus (EBV) infection and cytotoxic tissue-destructive features. Although ENKTL is described as a distinct entity according to the 2008 WHO classification, a considerable complexity is associated with the differential diagnosis of other T-cell lymphomas with respect to tumour cell origins, locations, and the presence of EBV infection, as well as molecular and cytogenetic abnormalities. Here, we report a rare case of EBV-negative ENKTL, where the absence of EBV in the true NK-lineage cells was confirmed by extensive phenotypic and genotypic analyses. Furthermore, using the next-generation sequencing approach, we identified mutations in the tumour suppressor genes KDM6A and TP53. The clinicopathological characteristics were almost similar to those of EBV-positive ENKTL, except for the absence of EBV and histologically apparent angioinvasiveness. This is the first reported ENKTL case with mutations in the KDM6A gene. KDM6A is one of the histone-modifying genes that are mutated in many human diseases including haematological cancers. Epigenetic regulation of gene expression has recently been demonstrated in ENKTL, and a similar pathway is thought to play an oncogenic role in EBV-negative ENKTL. Our report shows the extent of comprehensive examination required before making a definitive diagnosis for NK- and T-cell neoplasms and broadens the therapeutic options for potential targets.

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Primary Epstein–Barr virus-negative nasal-type natural killer/T cell lymphoma of the testis

Cited by 16 publications

References 6 publications

Peripheral T-cell lymphoma presenting as testicular mass; a diagnostic challenge

Peripheral T-cell lymphoma presenting as testicular mass; a diagnostic challenge

Comparative analysis of clinicopathologic characteristics and prognosis between nasal and nonnasal extranodal NK/T‐cell lymphoma

Epstein‐Barr virus‐negative extranodal “true” natural killer‐cell lymphoma harbouring a KDM6A mutation

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