Primary Endobronchial Marginal Zone B-Cell Lymphoma of Bronchus-Associated Lymphoid Tissue: CT Findings in 7 Patients

Abstract

ObjectiveTo investigate CT and 18F-flurodeoxyglucose (18F-FDG) positron-emission tomography/CT findings of primary endobronchial marginal zone B-cell lymphoma of the bronchus-associated lymphoid tissue (BALT).Materials and MethodsFrom June 2006 through April 2012, seven patients (six female, one male; age range, 21-61 years; mean age, 49 years) were examined who were pathologically diagnosed with the primary endobronchial marginal zone B-cell lymphoma of BALT. We evaluated the locations and characteristics of the lesions on CT and 18F-FDG-PET/CT scans. The lesions were classified into the following three patterns: 1) solitary intraluminal nodule; 2) several tiny nodular protrusions; and 3) diffuse wall thickening.ResultsA solitary intraluminal nodule was observed in four patients (57.1%), several tiny nodular protrusion in two patients (28.6%), and diffuse wall thickening in one patient (14.3%). The lesions were categorized into 3 major locations: confined to the trachea (n = 3), confined to the lobar bronchus (n = 2), and diffuse involvement of the trachea and both main bronchi (n = 2). All lesions demonstrated homogeneous iso-attenuation as compared with muscle on pre- and post-enhancement scans. Secondary findings in the lungs (n = 3; 42.9%) included postobstructive lobar atelectasis (n = 1), air trapping (n = 1), and pneumonia (n = 1). On 18F-FDG-PET/CT (n = 5), 4 lesions showed homogeneous uptake with maximum standardized uptake values (mSUV), ranging 2.3-5.7 (mean mSUV: 3.3). One lesion showed little FDG uptake.ConclusionPrimary endobronchial marginal zone B-cell lymphoma of the BALT manifests as three distinct patterns on CT, with the solitary intraluminal nodule presenting as the main pattern. Most lesions demonstrate homogeneous but weak FDG uptake on 18F-FDG-PET/CT.

Primary Tracheal Mucosa-Associated Lymphoid Tissue Lymphoma Treated with a Water-Jet Hybrid Knife: A Case Report

“…The pathogenic mechanisms of tracheal MALT lymphoma remain elusive, although it has been proposed that the disease is related to smoking, chronic inflammation, and autoimmune diseases [4, 5]. A Korean study reported that positron emission tomography-CT displayed some diagnostic merit for tracheal MALT lymphoma, with the maximum standardized uptake values ranging between 2.3 and 5.7 [6], which is consistent with our results. In addition, the study also reported that lesions of primary MALT lymphoma manifested no significant signal intensification in an enhanced CT scan, which clearly differed from our observation that some areas of the lesions did show an apparent enhancement.…”

Detection rate of fluorine‐18‐fluorodeoxyglucose positron emission tomography in patients with marginal zone lymphoma of MALT type: a meta‐analysis

“…By reviewing titles and abstracts, 450 articles were excluded: 335 because they were not in the field of interest of this review; 20 because they were reviews, editorials or letters; 93 because they were case reports or small case series (less than five patients with MALT lymphoma); and two articles because they were not in the English language. Thus, 30 full‐text articles were assessed for eligibility . One additional study was found by screening the references of these articles .…”

“…Finally, 20 articles including 376 patients were selected and were eligible for the systematic review and meta‐analysis (Figure ). The characteristics of the included studies are presented in Tables .…”

“…Using the database search, 20 original articles written over the past 10 years were selected . About the study design, 19 were retrospective studies , and in one article, this information was not provided . Only one study was bicentric , whereas the other 19 studies were monocentric .…”

“…About the study design, 19 were retrospective studies , and in one article, this information was not provided . Only one study was bicentric , whereas the other 19 studies were monocentric . About the lesion site, the DR of 18 F‐FDG PET or PET/CT was evaluated by 10 studies for gastric MALT lymphoma , seven articles for ocular MALT lymphoma (including conjunctival and/or orbital adnexal lymphoma) , five studies for head‐and‐neck MALT lymphoma and eight articles for bronchial MALT lymphoma (Table ).…”