Primary cutaneous nocardiosis

Abstract

A case of primary cutaneous nocardiosis due to Nocardia asteroides occurring in a steroid-dependent asthmatic with no history of trauma is presented. He had a 5 month history of painful nodules on his right shin and calf. He was initially treated with a 6 week course of oral cephalexin 500 mg four times daily, followed by a 2 week course of minocycline 100 mg twice daily with worsening of the infection. A 12 week course of oral clarithromycin 500 mg twice daily led to complete resolution. A discussion of the problems associated with antimicrobial susceptibility testing and nocardia resistance is presented.

Nocardiainfections in cats: a retrospective multi‐institutional study of 17 cases

“…It is possible that, like rapidly growing mycobacteria, Nocardia spp favour anatomic regions high in fat. The resulting lesions bear many similarities to actinomycotic mycetomas in people, 68 a condition observed most often in barefoot rural workers. However, unlike the situation in people, N brasiliensis was not the culprit.…”

Primary cutaneous nocardiosis due to Nocardia nova in a healthy woman .

“…A skin test with PPD was negative and the infection was resistant to therapy. Lee and Sippe reported a man with primary cutaneous nocardiosis 8 . The lesion consisted of tender, erythematous, poorly defined, crusted nodules on the lower right leg.…”

“…Lee and Sippe reported a man with primary cutaneous nocardiosis. 8 The lesion consisted of tender, erythematous, poorly defined, crusted nodules on the lower right leg. The type was a superficial skin infection.…”

Skin Infections

“…135 The classic route of infection is via the respiratory tract (inhalation), with pulmonary infection and subsequent systemic dissemination, mainly to the central nervous system (CNS) and to the skin. 134,137 However, secondary hematogenous nocardiosis skin lesions may be indistinguishable to the primary cutaneous form, so it is always important to evaluate affected patients for pulmonary lesions. 129,130,136 Immunocompetent individuals acquire cutaneous lesions through traumatic percutaneous inoculation, usually through contaminated thorns.…”