Primary cutaneous adenoid cystic carcinoma: A clinical and histopathological mimic: A case report

Tiwari, Raja; Agarwal, Savita; Sharma, Manik; Gaba, Sunil

doi:10.1016/j.omsc.2018.09.002

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…Primary cutaneous ACC (PCACC) is a rare tumor arising directly from the skin. 8 Although its histogenesis is not known with certainty, there are studies suggesting that it has apocrine or eccrine origin. 9,10 It presents as a slow growing, solitary mass in middle aged and elderly patients.…”

Section: Discussionmentioning

confidence: 99%

Eccrine spiradenoma mimicking adenoid cystic carcinoma cytologically (Two case reports and literature review)

Guzelbey

Leblebıcı

Koca

2021

Diagnostic Cytopathology

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Section: Discussionmentioning

confidence: 99%

Eccrine spiradenoma mimicking adenoid cystic carcinoma cytologically (Two case reports and literature review)

Guzelbey

Leblebıcı

Koca

2021

Diagnostic Cytopathology

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“…6 PCACC can be locally aggressive, and current literature shows that metastasis is possible, although previously reported to be rarer than in its counterparts arising in other sites. 7 Treatment is typically via surgical excision; less commonly, patients are also treated with concurrent radiation or chemotherapy. 8 PCACC is most commonly found to occur on the skin of the head and neck, 8 but demographics, prognosis, and other characteristics specific to head and neck tumors are largely unknown.…”

Section: Introductionmentioning

confidence: 99%

“…Most examinations of this tumor have been included in studies looking at PCACC arising from any primary site on the body or have been limited to case series, case reports, and components of literature reviews. 3,4,7-14 As a result, there is little documented insight into demographic characteristics of this tumor or factors that can impact survival and mortality. There is also little known about the ideal treatment modality for PCACC of the head and neck.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Characteristics and Survival of Primary Cutaneous Adenoid Cystic Carcinoma of the Head and Neck

Behbahani

Wassef

Povolotskiy

et al. 2020

Ann Otol Rhinol Laryngol

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Background/Objectives: Primary cutaneous adenoid cystic carcinoma (PCACC) is a rare skin tumor. The head and neck (H&N) is the most common anatomical location. Due to limited published cases, its clinical course and management are not well understood. Methods: The National Cancer Database (NCDB) was queried for all cases of H&N PCACC diagnosed from 2004 to 2016. Kaplan–Meier (KM) and Cox proportional hazards models were used to determine clinicopathological and treatment factors associated with survival outcomes. Results: A total of 201 cases were analyzed. The average age of diagnosis was 57.7 years (± SD 15.8). There was a female predilection (57.7%; P < .05) with the most common primary site being the ear (58.2%). The average tumor size was 15.9 mm in diameter. The most common treatment was surgery alone (51.7%) with wide local excision being the common surgery performed (36.3%). 5-year and 10-year OS were 87.0% and 76.0%, respectively. A total of 65.8% of cases were localized (Stage I and II). KM analysis indicated that gender, age, insurance status, Charlson-Deyo Comobordity Score, and stage were significant predictors of OS ( P < .05). Cox proportional hazards analysis revealed that patients with both private (HR 0.11, 95%CI [0.019-0.670]; P = .02) and government (HR 0.12, 95%CI [0.019-0.972]; P = .03) health insurance had a significantly decreased hazard of death than patients who were uninsured. Increasing age was associated with an increased hazard of death (HR 1.06, 95%CI [1.016-1.110]; P = .01). Conclusion: This study represents the largest cohort of H&N PCACC studied to date and provides important clinicopathologic information for this rare tumor. Additionally, our results emphasize the importance of health insurance as an independent predictor of survival in PCACC.

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Spiradenoma With Adenoid Cystic Carcinoma–Like Features

Hopkins

Moyer

Huttenbach

2019

The American Journal of Dermatopathology

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Spiradenoma is a benign cutaneous adnexal neoplasm that characteristically presents as a painful dermal nodule, often on the head or trunk. It has a distinct histologic phenotype and management involves surgical excision with low risk of recurrence. In comparison, adenoid cystic carcinoma (ACC) is a low-grade malignancy manifesting as an often painless subcutaneous mass with potential for local invasion, perineural extension, and high rates of recurrence after excision. We report the case of a 63-year-old male patient with a recurrent, painful hematoma-like cyst overlying the left lower extremity tibial tuberosity. A firm nodule was located at the base of the cyst, which was histologically consistent with spiradenoma. Interestingly, the lesion contained multifocal ACC-like components composed of epithelial basaloid cells surrounding pseudocystic structures filled with mucinous material. The ACC-like components did not demonstrate infiltration or perineural invasion. To the best of our knowledge, this is the second publication in the English literature regarding spiradenoma with an ACC-like pattern. Although a benign entity, knowledge of this morphological variant of spiradenoma is essential for diagnostic accuracy in these cases. If a limited biopsy captures only the ACC-like component of a spiradenoma, the lesion may be incorrectly diagnosed as ACC.

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Primary cutaneous adenoid cystic carcinoma: A clinical and histopathological mimic: A case report

Cited by 3 publications

References 21 publications

Eccrine spiradenoma mimicking adenoid cystic carcinoma cytologically (Two case reports and literature review)

Eccrine spiradenoma mimicking adenoid cystic carcinoma cytologically (Two case reports and literature review)

Analysis of Characteristics and Survival of Primary Cutaneous Adenoid Cystic Carcinoma of the Head and Neck

Spiradenoma With Adenoid Cystic Carcinoma–Like Features

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