Primary chronic osteomyelitis of the jaw—a microbial investigation using cultivation and DNA analysis: a pilot study

Frid, Paula; Tornes, Knut; Nielsen, Øyunn; Skaug, Nils

doi:10.1016/j.tripleo.2009.01.020

Cited by 25 publications

(27 citation statements)

References 15 publications

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“…Also, in contrast to the maxilla, the mandible has only a single blood supply source, from the inferior alveolar neurovascular bundle [8, 9]. In agreement with the literature [10, 11], all of our cases developed in the mandible.…”

Section: Discussionsupporting

confidence: 87%

“… Case 1 evolved for 2 months, characterizing chronic osteomyelitis. The most common findings of osteomyelitis are diffuse sclerosis, a peripheral sclerotic rim, cortical layering (involucrum), central loss of trabecular pattern with internal round radiolucent resorptive tracts, minimal jaw expansion, and reduction of the alveolar cortex on radiographic examination [8, 11], features which were also presents in our case.…”

Section: Discussionmentioning

confidence: 52%

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Clinical Management of Suppurative Osteomyelitis, Bisphosphonate-Related Osteonecrosis, and Osteoradionecrosis: Report of Three Cases and Review of the Literature

Guimarães

Pedreira

Jham

et al. 2013

Case Reports in Dentistry

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In the past, osteomyelitis was frequent and characterized by a prolonged course, treatment response uncertainty, and occasional disfigurement. Today, the disease is less common; it is believed that the decline in prevalence may be attributed to increased availability of antibiotics and improvement of overall health patterns. Currently, more common osteomyelitis variants are seen, namely, osteoradionecrosis (ORN) and bisphosphonate-related osteonecrosis of the jaws (BRONJ). Osteomyelitis, ORN, and BRONJ can present with similar symptoms, signs, and radiographic findings. However, each condition is a separate entity, with different treatment approaches. Thus, accurate diagnosis is essential for adequate management and improved patient prognosis. The aim of this paper is to report three cases of inflammatory lesions of the jaws—osteomyelitis, ORN, and BRONJ—and to discuss their etiology, clinical aspects, radiographic findings, histopathological features, treatment options, and preventive measures.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 52%

Clinical Management of Suppurative Osteomyelitis, Bisphosphonate-Related Osteonecrosis, and Osteoradionecrosis: Report of Three Cases and Review of the Literature

Guimarães

Pedreira

Jham

et al. 2013

Case Reports in Dentistry

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“…We performed a biopsy only after careful radiography to exclude malignancy; we sought to understand the nature of the lesion more fully. We preferred an intraoral approach given the site and size of the lesion, the fact that the lesion was intraorally accessible, and because we considered external access excessive in a 10-year-old girl, even though the literature describes such an approach [26].…”

Section: Discussionmentioning

confidence: 99%

Chronic nonbacterial osteomyelitis involving the mandible: A case report

Bocchialini

Ferrari

Rossini

et al. 2017

International Journal of Surgery Case Reports

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HighlightsChronic recurrent multifocal osteomyelitis (CMRO), or chronic nonbacterial osteomyelitis (CNO), is a very rare condition of unknown aetiology. It is characterised by focal sterile inflammatory disease with prolonged, self-limiting and recurrent episodes.Relatively few cases of CMRO have been reported since the first description in 1972 by Giedion, and is poorly characterised in the maxillofacial surgery literature due to the use of inconsistent terminology.CMRO is a very rare disease characterised by recurrent flare-ups of inflammatory bone pain related to aseptic osteomyelitis; lesions can be unifocal (CNO) or multifocal (CMRO).The proper course of treatment for CMRO remains unclear and no standard therapy is available.

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“…A broad range of bacteria has been implicated in osteomyelitis of the jaw, most of which are normal oral flora. 6,7,10,13,20,28 While antimicrobial therapy is recognized as an important component of comprehensive treatment of oral osteomyelitis, aerobic and anaerobic cultures may be unrewarding in humans 12,15 and cats. 3,5 A combined therapy is recommended: periodontal debridement (or extraction of involved teeth), oral antibiotics, pain medication, and osteoplasty of alveolar bone.…”

Section: Discussionmentioning

confidence: 99%

Histologic, Clinical, and Radiologic Findings of Alveolar Bone Expansion and Osteomyelitis of the Jaws in Cats

Bell

Soukup

2015

Vet Pathol

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The objective of this study was to characterize clinical, radiologic, and histologic patterns of alveolar bone expansion and osteomyelitis in cats. Based on case materials submitted as surgical biopsy specimens, alveolar bone pathology was diagnosed in 28 cats. These cats had a total of 37 oral lesions with clinical and radiologic changes that involved bone and/or teeth, including periodontitis, bone expansion, tooth resorption, and/or chronic osteomyelitis; 32 lesions were evaluated by histopathology. Canine teeth were affected in 19 cats (27 affected teeth), with bilateral lesions in 5 (26.3%) cats. The caudal premolar and/or molar regions were affected in 10 cats (10 affected sites). All biopsy sites evaluated by a review of clinical images and/or radiographs had evidence of periodontitis. Clinical photographs showed expansion of alveolar bone in 13 of 16 (81%) biopsy sites evaluated. Radiologically, rarifying osseous proliferation of alveolar bone was seen at 26 of 27 (96%) biopsy sites, and tooth resorption occurred at 15 of 18 (83%) sites. Histologically, the tissue samples from canine sites had compressed trabeculae of mature remodeled bone, loose fibrous stroma with paucicellular inflammation, and mild proliferation of woven bone. Tissue samples from the premolar/molar biopsy sites were often highly cellular with mixed lymphoplasmacytic and chronic suppurative inflammation, ulceration with granulation tissue, and robust proliferation of woven bone. Alveolar bone expansion and osteomyelitis in cats occurs in conjunction with periodontal inflammation and frequently with tooth resorption.

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Primary chronic osteomyelitis of the jaw—a microbial investigation using cultivation and DNA analysis: a pilot study

Cited by 25 publications

References 15 publications

Clinical Management of Suppurative Osteomyelitis, Bisphosphonate-Related Osteonecrosis, and Osteoradionecrosis: Report of Three Cases and Review of the Literature

Clinical Management of Suppurative Osteomyelitis, Bisphosphonate-Related Osteonecrosis, and Osteoradionecrosis: Report of Three Cases and Review of the Literature

Chronic nonbacterial osteomyelitis involving the mandible: A case report

Histologic, Clinical, and Radiologic Findings of Alveolar Bone Expansion and Osteomyelitis of the Jaws in Cats

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