Primary cardiac angiosarcoma: A case report and review of therapeutic options

Stein, Moshe; Deitling, Freddy; Cantor, Angel; Perner, Yvonne; Bezwoda, W. R.

doi:10.1002/mpo.2950230216

Cited by 12 publications

(5 citation statements)

References 21 publications

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“…In two studies, patients had metastatic involvement at presentation in 66% and 89% of cases (5,6). There have been recent reports of survival from 12 to 30 months with some combination of chemotherapy, surgery, radiation therapy, and transplantation (10,16,17). Others studies have shown poor results with chemotherapy (18), and the overall experience with heart transplantation is poor (19,20).…”

Section: Introductionmentioning

confidence: 99%

CT and MR Imaging of Primary Cardiac Malignancies

Araoz¹,

Eklund²,

Welch³

et al. 1999

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Primary cardiac malignancies are rare tumors that are difficult to diagnose clinically. Different primary cardiac malignancies may have different clinical, morphologic, and radiologic features and intracardiac locations. Angiosarcoma is the most common primary cardiac malignancy. It tends to occur in the right atrium and involve the pericardium. Because of its tendency to hemorrhage, angiosarcoma often demonstrates areas of increased signal intensity with T1-weighted sequences. Undifferentiated sarcomas typically occur in the left atrium and have variable epidemiologic and radiologic features. Rhabdomyosarcoma is the most common primary cardiac malignancy in children and is more likely than other primary cardiac sarcomas to involve the valves. Primary cardiac osteogenic sarcoma almost always occurs in the left atrium and frequently demonstrates calcification. Certain features (eg, broad base of attachment, origin at a site other than the atrial septum) help differentiate this tumor from left atrial myxoma. Leiomyosarcoma favors the left atrium and tends to invade the pulmonary veins and mitral valve. Fibrosarcoma also tends to occur in the left atrium and is often necrotic. Liposarcoma is very rare and usually manifests as a large, infiltrating mass. Foci of macroscopic fat are occasionally seen. Primary cardiac lymphoma occurs more commonly in immunocompromised patients, frequently involves the pericardium, and, unlike other primary cardiac malignancies, may respond to chemotherapy. The advent of cross-sectional imaging has allowed earlier detection of primary cardiac malignancies as well as more accurate diagnosis and characterization.

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Section: Introductionmentioning

confidence: 99%

CT and MR Imaging of Primary Cardiac Malignancies

Araoz¹,

Eklund²,

Welch³

et al. 1999

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325

203

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“…14 The most important cytostatics are Adriamycin, ifosfamid, or cyclophosphamide and dacarbazine accompanied by treatment with MESNA and, if necessary, G-CSF (granulocyte-stimulating factor). 14,18,19 Heart transplantation as treatment of primary cardiac soft tissue sarcoma is controversial. 3,16,20 Four patients with cardiac soft tissue sarcomas underwent heart transplantation followed by postoperative chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Angiosarcoma Diagnosed and Characterized by Cardiac Magnetic Resonance Imaging

Deetjen

Conradi

Möllmann

et al. 2006

Cardiology in Review

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“…Frequent metastases are common and surgical excision often impossible due to extensive pericardial involvement [10]. Radiotherapy and surgery may offer some relief, but there is no clear evidence that they reduce mortality [8].…”

Section: Discussionmentioning

confidence: 99%

“…Two pathologic types of cardiac angiosarcoma have been described [8]. In the first type, the tumor is large, pedunculated, and protrudes into the right atrial cavity where it can cause obstruction of the tricuspid valve or the inferior vena cava.…”

Section: Discussionmentioning

confidence: 99%