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“…Dementia contributes to signi cant morbidity in APS and the incidence of dementia in APS is high in some studies. 44,45 There are a number of reports linking vascular dementia with APS [46][47][48][49] though Mosek et al 50 found that aPL are associated mainly with primary degenerative dementia. Direct binding of aPL to brain tissue [51][52][53][54] may point to an alternative pathogenic mechanism underlying the cognitive de cits associated with APS.…”
Section: Dementiamentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Dementia contributes to signi cant morbidity in APS and the incidence of dementia in APS is high in some studies. 44,45 There are a number of reports linking vascular dementia with APS [46][47][48][49] though Mosek et al 50 found that aPL are associated mainly with primary degenerative dementia. Direct binding of aPL to brain tissue [51][52][53][54] may point to an alternative pathogenic mechanism underlying the cognitive de cits associated with APS.…”
Section: Dementiamentioning
“…Dementia is a signi cant morbidity and its incidence in APS has been found to be high in some studies. 3,4 There are a number of reports linking vascular dementia with APS [5][6][7][8] which would support a link between APS and ischaemic stroke. Similarly, an important group of patients with ischaemic stroke and Sneddon syndrome overlap with APS 9 and these patients may suffer from severe vascular dementia.…”
Section: Dementia and Psychiatric Diseasementioning
“…Incidence of dementia in APS is high in some studies 50,51. There are a number of reports linking vascular dementia with APS,52–55 although Mosek et al have found aPLs are associated primarily with primary degenerative dementia 56. Direct binding of aPLs to brain tissue57–60 may point to alternative pathogenic mechanisms underlying the cognitive deficits associated with APS.…”
Section: Discussionmentioning