Primary angioplasty versus intravenous thrombolysis for acute myocardial infarction

Abstract

Primary angioplasty versus intravenous thrombolysis for acute myocardial infarction.

Prognostic impact of non-compliance with guidelines-recommended times to reperfusion therapy in ST-elevation myocardial infarction. The FAST-MI 2010 registry

“…26 This study confirms that early fibrinolytic treatment is effective and should be considered as an alternative to PPCI, even if fibrinolysis is associated with a slightly increased risk of intracranial bleeding, especially in elderly patients. 18,[27][28][29][30][31][32] Therefore, in conjunction with previous data from the long-term follow-up of the FAST-MI 2005 registry, our current results support the concept of using a pharmaco-invasive strategy as an alternative to PPCI, when guidelines recommendations cannot be achieved. 33 The real challenge for the emergency medical system will therefore be to ascertain when PPCI cannot be performed within 90/120 min of first medical contact.…”

“…26 This study confirms that early fibrinolytic treatment is effective and should be considered as an alternative to PPCI, even if fibrinolysis is associated with a slightly increased risk of intracranial bleeding, especially in elderly patients. 18,27–32…”

Prognostic impact of non-compliance with guidelines-recommended times to reperfusion therapy in ST-elevation myocardial infarction. The FAST-MI 2010 registry

“…26 This study confirms that early fibrinolytic treatment is effective and should be considered as an alternative to PPCI, even if fibrinolysis is associated with a slightly increased risk of intracranial bleeding, especially in elderly patients. 18,[27][28][29][30][31][32] Therefore, in conjunction with previous data from the long-term follow-up of the FAST-MI 2005 registry, our current results support the concept of using a pharmaco-invasive strategy as an alternative to PPCI, when guidelines recommendations cannot be achieved. 33 The real challenge for the emergency medical system will therefore be to ascertain when PPCI cannot be performed within 90/120 min of first medical contact.…”

“…26 This study confirms that early fibrinolytic treatment is effective and should be considered as an alternative to PPCI, even if fibrinolysis is associated with a slightly increased risk of intracranial bleeding, especially in elderly patients. 18,27–32…”

Cardiovascular events and their outcome in diabetes and in people with prediabetes in the Coronary Unit of a Secondary General Hospital

“…The use of reperfusion in this case of thrombolysis in the Coronary Unit of the Secondary General Hospital, reaches a rate that can be compared with most European countries. Combined thrombolysis treatment and then transfer to an ICU for further treatment, as recent studies have shown the results of immediate thrombolysis and rapid transfer to an ICU are similar to those when the person enters the ICU directly (Cucherat et al 2002, Antman et al 2008) [12] . The outcome death shows a high rate compared to another prospective study (Sarker et al 2007) [28] , as well as from a Greek epidemiological study of Acute Coronary Syndrome (GREECS, 2003(GREECS, -2004 and this difference has to do with the fact that in the present retrospective study the outcome death corresponds to all cases-patients with any cardiovascular event, with which they were admitted to the Coronary Unit and not separately for each cardiovascular event.…”

Nebulized Non-Immunogenic Staphylokinase in the Mice Acute Lung Injury Model

“…It is well established in clinical trials that i.v. administration of fibrinolytics has numerous limitations and contraindications [ 22 , 23 , 24 ]. The inhalation of fibrinolytics may decrease these side effects in former trials.…”

Prognostic impact of non-compliance with guidelines-recommended times to reperfusion therapy in ST-elevation myocardial infarction. The FAST-MI 2010 registry

“…26 This study confirms that early fibrinolytic treatment is effective and should be considered as an alternative to PPCI, even if fibrinolysis is associated with a slightly increased risk of intracranial bleeding, especially in elderly patients. 18,[27][28][29][30][31][32] Therefore, in conjunction with previous data from the long-term follow-up of the FAST-MI 2005 registry, our current results support the concept of using a pharmaco-invasive strategy as an alternative to PPCI, when guidelines recommendations cannot be achieved. 33 The real challenge for the emergency medical system will therefore be to ascertain when PPCI cannot be performed within 90/120 min of first medical contact.…”

“…26 This study confirms that early fibrinolytic treatment is effective and should be considered as an alternative to PPCI, even if fibrinolysis is associated with a slightly increased risk of intracranial bleeding, especially in elderly patients. 18,27–32…”

Cardiovascular events and their outcome in diabetes and in people with prediabetes in the Coronary Unit of a Secondary General Hospital

“…The use of reperfusion in this case of thrombolysis in the Coronary Unit of the Secondary General Hospital, reaches a rate that can be compared with most European countries. Combined thrombolysis treatment and then transfer to an ICU for further treatment, as recent studies have shown the results of immediate thrombolysis and rapid transfer to an ICU are similar to those when the person enters the ICU directly (Cucherat et al 2002, Antman et al 2008) [12] . The outcome death shows a high rate compared to another prospective study (Sarker et al 2007) [28] , as well as from a Greek epidemiological study of Acute Coronary Syndrome (GREECS, 2003(GREECS, -2004 and this difference has to do with the fact that in the present retrospective study the outcome death corresponds to all cases-patients with any cardiovascular event, with which they were admitted to the Coronary Unit and not separately for each cardiovascular event.…”

Nebulized Non-Immunogenic Staphylokinase in the Mice Acute Lung Injury Model

“…It is well established in clinical trials that i.v. administration of fibrinolytics has numerous limitations and contraindications [ 22 , 23 , 24 ]. The inhalation of fibrinolytics may decrease these side effects in former trials.…”

Prognostic impact of non-compliance with guidelines-recommended times to reperfusion therapy in ST-elevation myocardial infarction. The FAST-MI 2010 registry

“…26 This study confirms that early fibrinolytic treatment is effective and should be considered as an alternative to PPCI, even if fibrinolysis is associated with a slightly increased risk of intracranial bleeding, especially in elderly patients. 18,[27][28][29][30][31][32] Therefore, in conjunction with previous data from the long-term follow-up of the FAST-MI 2005 registry, our current results support the concept of using a pharmaco-invasive strategy as an alternative to PPCI, when guidelines recommendations cannot be achieved. 33 The real challenge for the emergency medical system will therefore be to ascertain when PPCI cannot be performed within 90/120 min of first medical contact.…”

“…26 This study confirms that early fibrinolytic treatment is effective and should be considered as an alternative to PPCI, even if fibrinolysis is associated with a slightly increased risk of intracranial bleeding, especially in elderly patients. 18,27–32…”

Cardiovascular events and their outcome in diabetes and in people with prediabetes in the Coronary Unit of a Secondary General Hospital

“…The use of reperfusion in this case of thrombolysis in the Coronary Unit of the Secondary General Hospital, reaches a rate that can be compared with most European countries. Combined thrombolysis treatment and then transfer to an ICU for further treatment, as recent studies have shown the results of immediate thrombolysis and rapid transfer to an ICU are similar to those when the person enters the ICU directly (Cucherat et al 2002, Antman et al 2008) [12] . The outcome death shows a high rate compared to another prospective study (Sarker et al 2007) [28] , as well as from a Greek epidemiological study of Acute Coronary Syndrome (GREECS, 2003(GREECS, -2004 and this difference has to do with the fact that in the present retrospective study the outcome death corresponds to all cases-patients with any cardiovascular event, with which they were admitted to the Coronary Unit and not separately for each cardiovascular event.…”

Nebulized Non-Immunogenic Staphylokinase in the Mice Acute Lung Injury Model

“…It is well established in clinical trials that i.v. administration of fibrinolytics has numerous limitations and contraindications [ 22 , 23 , 24 ]. The inhalation of fibrinolytics may decrease these side effects in former trials.…”