Primary adenoid cystic carcinoma of skin

Abstract

Two primary adenoid cystic carcinomas of skin were studied histologically and histochemically. Histologically, they closely resemble adenoid cystic carcinoma found in other tissues but in the skin must be distinguished from aggressive basal cell carcinomas. The natural history of these tumors and of those collected from the literature suggest a long indolent and progressive course. Local excision with meticulous histologic control of the surgical margins appears to be an appropriate therapeutic strategy. Thus far lymph node metastases have not been observed.

Adnexal Metaplasia in Carcinoma in situ of the Skin

“…The mucin produced by cutaneous adnexal tumors is often sialomucin. The mucin produced by basal cell carcinomas and the rare, true adenoid cystic carcinomas contains a high proportion of hyaluronic acid (Headington et al 1978). Ihe mucin of our tumor seems to be similar histochemically to the mucins produced by primary mucinous carcinoma of the skin (Mendoza & Helwig 1971, Headington 1977, Santa Cruz et al 1978) and certain adenomas of sweat gland origin (Lennox el al.…”

Cutaneous Adenoid Cystic Carcinoma with Perineural Invasion Treated by Mohs Micrographic Surgery—A Case Report with Literature Review

“…Microscopic findings of cutaneous ACC are characterized by basaloid cells in the mid to deep dermis, arranged in cords and islands forming tubular structures and cribriform patterns, usually with a lack of connection to the overlying epidermis or adnexal structures [6, 7]. There may be small cystic spaces containing mucinous material that stains positively for hyaluronic acid.…”

“…The lumina of the tubular structures and the surrounding stroma may contain mucin or eosinophilic necrotic cells. True lumina are surrounded by prominent basement membrane material, which is PAS positive, diastase-resistant [6, 7]. Perineural invasion is often seen [6, 7].…”

Primary cutaneous adenoid cystic carcinoma: ultrastructural study and immunolocalization of Types I, III, IV, V collagens and laminin

“…Primary cutaneous adenoid cystic carcinoma is very rare. To date, about twenty cases have been reported (4)(5)(6)(7)(8). They were described as very slow growing, usually asymptomatic, discrete nodules affecting middle aged and older individuals.…”

“…This type of tumor has also been reported in other glandular tissues, including the tracheobronchial tree, breast, uterine cervix, larynx, esophagus, Bartholin glands ofthe vulva and prostate gland (2,3). Primary adenoid cystic carcinoma of the skin, excluding lesions ofthe external auditory canal, is very rare (4)(5)(6)(7)(8). Here, we report on a patient with a neoplasm with typical morphological features of ACC, and describe the uitrastructural findings and characterize the collagen types of the tumor.…”