Primary acquired agammaglobulinemia, with granulomas of the skin and internal organs

Skinner, M. D.

doi:10.1001/archderm.102.1.109

Cited by 12 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This syndrome is characterized by noninfectious granulomas in the lungs, liver, spleen or conjunctivae indistinguishable from classical sarcoidosis [12]. However, the development of cutaneous granulomas was mainly described in patients with visceral granulomas [7, 9, 13, 14, 15], and isolated cutaneous granulomas were rarely reported [16, 18, 19]. …”

Section: Commentmentioning

confidence: 99%

See 1 more Smart Citation

Cutaneous Granulomatous Lesions in Common Variable Immunodeficiency: Complete Resolution after Intravenous Immunoglobulins

Nadal¹,

Ferrer²,

Diaz³

et al. 1999

Dermatology

View full text Add to dashboard Cite

A 64-year-old man with common variable immunodeficiency developed a persistent papulonodular ulcerative eruption on the right leg. Histopathological examination disclosed a chronic inflammatory infiltrate with central necrosis and palisading granuloma. Repeated microbiological (bacteriological, mycological and mycobacteriological) studies failed to isolate any microorganism. After treatment with intravenous immunoglobulins, a progressive resolution of the skin lesions was observed with a complete clearing after 10 months. Clinicopathological features and therapeutic approaches of sterile granulomatous lesions associated with primary immunodeficiencies are reviewed.

show abstract

Section: Commentmentioning

confidence: 99%

“…Caseating (tuberculoid) granulomas [18]or the combination of caseating and noncaseating granulomas have been observed [15]. Occasionally, necrobiotic palisading granulomas have also been noted [7, 8].…”

Section: Commentmentioning

confidence: 99%

Cutaneous Granulomatous Lesions in Common Variable Immunodeficiency: Complete Resolution after Intravenous Immunoglobulins

Nadal¹,

Ferrer²,

Diaz³

et al. 1999

Dermatology

View full text Add to dashboard Cite

show abstract

“…In our patient, we started pulsed antibiotic therapy with co‐trimoxazole and azithromycin, in conjunction with intravenous gamma globulin every 3 weeks, with improvement of general symptoms, while cutaneous manifestations were unchanged. Sarcoid‐like granulomas in immunodeficiency syndrome may be responsive to corticosteroid therapy (5), but because of the increased risk of infection, caution should be exercised before administering systemic corticosteroids to an immunocompromised patient (23). In our patient, a topical corticosteroid (methylprednisolone) reduced the infiltrative cutaneous component, but when it was discontinued, the cutaneous lesions recurred.…”

Section: Discussionmentioning

confidence: 99%

“…Noninfectious cutaneous granulomas, particularly in an acral distribution, are considered an early sign of mixed cellular and humoral immunodeficiency. They have rarely been reported in children with immunodeficiency disorders (5–7), and never in patients with HIM syndrome.…”

mentioning

confidence: 99%

Cutaneous Sarcoid‐like Granulomas in a Patient with X‐Linked Hyper‐IgM Syndrome

Gallerani

Innocenti

Coronella

et al. 2004

Pediatric Dermatology

View full text Add to dashboard Cite

We describe a 5-year-old boy with red-pink, firm, nodular lesions, with central resolution and prominent borders, localized to the face, backs of the hands, extensor surfaces of the arms and legs, and the buttocks. He also had recurrent bacterial respiratory infections. Quantitative immunoglobulin levels revealed hypogammaglobulinemia and increased IgM levels. Histopathologic examination of a nodular lesion revealed perivascular and periadnexal granulomas composed of epithelioid cells surrounded by a mantle of lymphocytes; three cultures for fungi and acid-fast bacilli were negative. Clinical, histopathologic, and immunologic studies supported a diagnosis of hyper-IgM (HIM) syndrome. The boy was treated with pulsed-dose antibiotics and intravenous gamma globulin every 3 weeks, with improvement of clinical symptoms. Skin lesions were treated with topical corticosteroids, with immediate recurrence upon cessation of therapy. To the best of our knowledge, this is the first description of cutaneous granulomas in HIM syndrome.

show abstract

Caseating cutaneous granulomas in a patient witl X-linked infantile hypogammaglobulinemia

Fleming

Gewurz²,

Pearson³

1991

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

Primary acquired agammaglobulinemia, with granulomas of the skin and internal organs

Cited by 12 publications

References 0 publications

Cutaneous Granulomatous Lesions in Common Variable Immunodeficiency: Complete Resolution after Intravenous Immunoglobulins

Cutaneous Granulomatous Lesions in Common Variable Immunodeficiency: Complete Resolution after Intravenous Immunoglobulins

Cutaneous Sarcoid‐like Granulomas in a Patient with X‐Linked Hyper‐IgM Syndrome

Caseating cutaneous granulomas in a patient witl X-linked infantile hypogammaglobulinemia

Contact Info

Product

Resources

About