Primär maligne Knochentumoren

Eisenhart-Rothe, R. von; Toepfer, Andreas; Salzmann, Maya; Schauwecker, Johannes; Gollwitzer, Hans; Rechl, H.

doi:10.1007/s00132-011-1866-7

Cited by 40 publications

(15 citation statements)

References 57 publications

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“…Sarcomas account for approximately 1 % of all adult cancers [ 1 ]. In this context soft tissue sarcomas typically occur in middle aged and older adults [ 1 ], whereas malignant bone tumors, i.e., osteosarcoma and Ewing’s sarcoma are more frequent in children and adolescents [ 2 , 3 ]. Progress in modern treatment regimens including neoadjuvant and adjuvant therapy has markedly improved the overall survival rates over the last decades [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Long-term functional outcome and quality of life following rotationplasty for treatment of malignant tumors

Gradl

Postl

Lenze

et al. 2015

BMC Musculoskelet Disord

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BackgroundMalignant bone tumors of the lower extremity are more frequently found in children and adolescents than in adults. Modern treatment regimens led to high limb salvage rates and offer the choice between endoprosthetic replacement and rotationplasty in many cases. Rotationplasty has proven to be an effective, highly functional option in short- and mid-term studies. Aim of this study was to assess long-term results regarding quality of life and functionality after rotationplasty and to compare the obtained results to a representative healthy German sample cohort.MethodsIn total 12 patients who underwent rotationplasty between 1991 and 2001 were enrolled in this study. After physical examination, they were evaluated regarding health related quality of life, functional outcome and psychosocial status. While quality of life was mainly assessed using the SF-36 (The Short Form (36) Health Survey v2), functional outcome was measured using the musculoskeletal tumor society score (MSTS) as well as the Tegner activity level scale.ResultsAverage age at the time of surgery was 19 ± 10 year. and 32 ± 11 year. at the time of follow up. Mean follow-up was 14 ± 9 years. The SF-36 scores accounted for 80.4 ± 15.7 regarding physical functioning, for 78.1 ± 24.1 regarding the physical role functioning, for 74.1 ± 17.6 regarding bodily pain and for 71.8 ± 26.1 regarding general health. SF-36 score for vitality was 75.0 ± 12.8, for social functioning 98.9 ± 3.6, 88.2 ± 23.9 for emotional role functioning and 89.6 ± 10.1 for the mental health. Comparison to a representative German sample cohort revealed significantly higher patient’s scores for vitality, social functioning and mental health (p < 0.05). The overall MSTS resulted in an average of 64 ± 12 % and the Tegner activity level scale accounted for 4.1 ± 0.6 pts.ConclusionsThe presented long-term results indicate that rotationplasty provides a high quality of life. Patients are satisfied with a good functional outcome regarding activities of daily life and even sports.

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Section: Introductionmentioning

confidence: 99%

Long-term functional outcome and quality of life following rotationplasty for treatment of malignant tumors

Gradl

Postl

Lenze

et al. 2015

BMC Musculoskelet Disord

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“…Since primary spinal sarcomas are very rare diseases24,25), the standard treatment method has not been established28,34,38,39). However, treatment for osteosarcoma and chondrosarcoma is being conducted in uniform fashion.…”

Section: Discussionmentioning

confidence: 99%

Survival and Recurrence Rate after Treatment for Primary Spinal Sarcomas

Cho

Chang

2013

J Korean Neurosurg Soc

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ObjectiveWe have limited understanding on the presentation and survival of primary spinal sarcomas. The survival, recurrence rate, and related prognostic factors were investigated after treatment for primary sarcomas of the spine.MethodsRetrospective analysis of medical records and radiological data was done for 29 patients in whom treatment was performed due to primary sarcoma of the spine from 2000 to 2010. As for treatment method, non-radical operation, radiation therapy, and chemotherapy were simultaneously or sequentially combined. Overall survival (OS), progression free survival (PFS), ambulatory function, and pain status were analyzed. In addition, factors affecting survival and recurrence were analyzed : age (≤42 or ≥43), gender, tumor histologic type, lesion location (mobile spine or rigid spine), weakness at diagnosis, pain at diagnosis, ambulation at diagnosis, initial treatment, radiation therapy, kind of irradiation, surgery, chemotherapy and distant metastasis.ResultsMedian OS was 60 months, the recurrence rate was 79.3% and median PFS was 26 months. Patients with distant metastasis showed significantly shorter survival than those without metastasis. No factors were found to be significant relating to recurrence. Prognostic factor associated with walking ability was the presence of weakness at diagnosis.ConclusionPrimary spinal sarcomas are difficult to cure and show high recurrence rate. However, the development of new treatment methods is improving survival.

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“…Unter den Knochentumoren wird der Anteil von gutartigen Neoplasien mit etwa 40-50 % angegeben, wobei aufgrund der hohen Dunkelziffer (symptomlose Tumoren, welche dauerhaft unentdeckt bleiben, Zufallsbefunde etc.) und tumorähnlichen Läsionen deren Anteil als deutlich höher einzuschätzen ist [1,2].…”

Section: Grundlagen Und Epidemiologieunclassified

“…Die Prognose des Osteo-sowie des Ewing-Sarkoms konnte durch die Einführung der neo-/adjuvanten Chemotherapie deutlich verbessert werden, das 5-Jahres-Überleben liegt heute für beide Entitäten bei etwa 70 %. Die Prognose wird hierbei maßgeblich durch Faktoren beeinflusst [2] wie ▪ Tumorlokalisation, -größe und -volumen, ▪ das histologische Ansprechen auf Chemotherapie, ▪ das Vorliegen und die Art (pulmonal versus ossär) von Metastasen sowie ▪ die Art des Fusionstranskripts (bei Ewing-Sarkomen).…”

Section: Maligne Knochentumorenunclassified