Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder

Lin, Ping; Ding, Bingyu; Feng, Chao; Yin, Shuwei; Zhang, Ting; Qi, Xin; Lv, Huiying; Guo, Xia; Dong, Ke; Zhu, Yongzhang; Li, Qingtian

doi:10.1016/j.jad.2016.09.051

Cited by 219 publications

(150 citation statements)

References 30 publications

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“…These bacteria can produce short-chain fatty acids, such as butyrate, acetic acid, and valeric acid. Previous studies observed higher levels of Klebsiella and Veillonella in MDD [26] and BD [27] patients, respectively. [22,24] Butyrate has been reported to be beneficial for many systemic disorders, such as hemoglobinopathy, genetic metabolic diseases, hypercholesterolemia, insulin resistance, and ischemic stroke.…”

Section: Discussionmentioning

confidence: 85%

Gut Microbiota Changes in Patients with Bipolar Depression

et al. 2019

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This study aims to characterize the gut microbiota in depressed patients with bipolar disorder (BD) compared with healthy controls (HCs), to examine the effects of quetiapine treatment on the microbiota, and to explore the potential of microbiota as a biomarker for BD diagnosis and treatment outcome. Analysis of 16S‐ribosomal RNA gene sequences reveals that gut microbial composition and diversity are significantly different between BD patients and HCs. Phylum Bacteroidetes and Firmicutes are the predominant bacterial communities in BD patients and HCs, respectively. Lower levels of butyrate‐producing bacteria are observed in untreated patients. Microbial composition changes following quetiapine treatment in BD patients. Notably, 30 microbial markers are identified on a random forest model and achieve an area under the curve (AUC) of 0.81 between untreated patients and HCs. Ten microbial markers are identified with the AUC of 0.93 between responder and nonresponder patients. This study characterizes the gut microbiota in BD and is the first to evaluate microbial changes following quetiapine monotherapy. Gut microbiota‐based biomarkers may be helpful in BD diagnosis and predicting treatment outcome, which need further validations.

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Section: Discussionmentioning

confidence: 85%

Gut Microbiota Changes in Patients with Bipolar Depression

et al. 2019

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“…Six studies have compared fecal microbiota of depressed patients with those of (healthy) control participants [31,32,[62][63][64][65]. Jiang et al [65] found significantly greater fecal microbial diversity based on the Shannon Index (which takes into account abundance and evenness of species) in a sample of 46 patients with MDD compared to 30 healthy controls.…”

Section: Major Depressive Disorder (Mdd)mentioning

confidence: 99%

“…One study investigated whether any correlations existed between repeated assessments (three visits) of fecal microbiota and depression scores in a period of one month [62]. Ten patients who experienced continuous reductions in depression scores (over these three visits) were compared to 10 healthy controls.…”

Section: Major Depressive Disorder (Mdd)mentioning

confidence: 99%

Gut microbiota, metabolism and psychopathology: A critical review and novel perspectives

Groen

Clercq

Nieuwdorp

et al. 2018

Critical Reviews in Clinical Laboratory Sciences

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“…Recent reports have demonstrated that consumption of select probiotic agents may represent a novel treatment method for major depressive disorder using a preclinical rodent model [56,57]. The veracity of these observations is substantiated by another therapeutic treatment, which influences gut, brain-gut communication, e.g., fecal transplantation [57–59].…”

Section: Antibiotics Probiotics and Behaviormentioning

confidence: 99%

“…The veracity of these observations is substantiated by another therapeutic treatment, which influences gut, brain-gut communication, e.g., fecal transplantation [57–59]. Depression-associated microbiota have been identified [60,61].…”

Section: Antibiotics Probiotics and Behaviormentioning

confidence: 99%

Microbiome: A Potential Component in the Origin of Mental Disorders

et al. 2017

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It is not surprising to find microbiome abnormalities present in psychiatric disorders such as depressive disorders, bipolar disorders, etc. Evolutionary pressure may provide an existential advantage to the host eukaryotic cells in that it survives in an extracellular environment containing non-self cells (e.g., bacteria). This phenomenon is both positive and negative, as with other intercellular processes. In this specific case, the phenomenal amount of information gained from combined bacterial genome could enhance communication between self and non-self cells. This can be coupled to both pathological processes and healthy ones.In this review, we chose to examine potential associated disorders that may be coupled to the microbiome, from the perspective of their bidirectional communication with eukaryotic cells in the gut. Cognition, being the newest neural networking functionality to evolve, consumes a good amount of organismic energy, 30% of which arises from the gut flora. Furthermore, the mammalian gut is highly innervated and has a highly developed immune component, reflecting brain complexity.The brain-gut axis uses similar molecular messengers as the brain, which affects bacterial processes as well. Thus, any modification of normal bacterial processes may manifest itself in altered behavior/cognition, originating from the gut. The origin of some disorders associated with this bidirectional communication may be harnessed to restore normal functioning.

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Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder

Cited by 219 publications

References 30 publications

Gut Microbiota Changes in Patients with Bipolar Depression

Gut Microbiota Changes in Patients with Bipolar Depression

Gut microbiota, metabolism and psychopathology: A critical review and novel perspectives

Microbiome: A Potential Component in the Origin of Mental Disorders

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